Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Pierre D. McCrea"'
Autor:
Yogesh Srivastava, Maxsam Donta, Lydia L. Mireles, Adriana Paulucci-Holthauzen, M. Neal Waxham, Pierre D. McCrea
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Neuronal connectivity is regulated during normal brain development with the arrangement of spines and synapses being dependent on the morphology of dendrites. Further, in multiple neurodevelopmental and aging disorders, disruptions of dendrite format
Externí odkaz:
https://doaj.org/article/98ceda0b3ffd4bd194e20e1ff25623d4
Autor:
Maxsam S. Donta, Yogesh Srivastava, Christina M. Di Mauro, Adriana Paulucci-Holthauzen, M. Neal Waxham, Pierre D. McCrea
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Dendritic arborization is essential for proper neuronal connectivity and function. Conversely, abnormal dendrite morphology is associated with several neurological pathologies like Alzheimer’s disease and schizophrenia. Among major intrinsic mechan
Externí odkaz:
https://doaj.org/article/9fa4f7da1ced4b6c9aa6286282a0504e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The molecular consequences of cancer associated mutations in Acute myeloid leukemia (AML) linked factors are not very well understood. Here, we interrogated the COSMIC database for missense mutations associated with the RUNX1 protein, that is frequen
Externí odkaz:
https://doaj.org/article/2e82d504969041b2823da39a4fdc4062
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry
Externí odkaz:
https://doaj.org/article/6519f2ad75f2459fa06215c8e31e5348
Autor:
Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen, Jae-Il Park
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a
Externí odkaz:
https://doaj.org/article/581765a279824025a9bb4b79da323deb
Autor:
Jayanarayanan Sadanandan, Sithara Thomas, Iny Elizabeth Mathew, Zhen Huang, Spiros L Blackburn, Nitin Tandon, Hrishikesh Lokhande, Pierre D McCrea, Emery H. Bresnick, Pramod K Dash, Devin McBride, Arif Harmanci, Dania Jose, Ari C Dienel, Hussein A Zeineddine, Sungha Hong, T Peeyush Kumar
The blood-brain barrier (BBB) controls the movement of molecules into and out of the central nervous system (CNS). Since a functional BBB forms by mouse embryonic day E15.5, we reasoned that gene cohorts expressed in CNS endothelial cells (EC) at E13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ee6b9f1bc79dbc71afa03110ab0119
https://doi.org/10.1101/2022.11.29.516809
https://doi.org/10.1101/2022.11.29.516809
Autor:
Rachel K. Miller, Ji Yeon Hong, Alexandria T.M. Blackburn, Pierre D. McCrea, Hong Ji, Jessica Zapata, Seung Min Bae, Ryan Baumert, Hee Jin Nam
Publikováno v:
Biochem Biophys Res Commun
Vertebrate beta-catenin plays a key role as a transducer of canonical-Wnt signals. We earlier reported that, similar to beta-catenin, the cytoplasmic signaling pool of p120-catenin-isoform1 is stabilized in response to canonical-Wnt signals. To obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e057db7942cda5a9bce4e9e505036a
https://doi.org/10.1016/j.bbrc.2021.05.043
https://doi.org/10.1016/j.bbrc.2021.05.043
Autor:
William A Munoz, Moonsup Lee, Rachel K Miller, Zamal Ahmed, Hong Ji, Todd M Link, Gilbert R Lee, Malgorzata Kloc, John E Ladbury, Pierre D McCrea
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86784 (2014)
Members of the plakophilin-catenin sub-family (Pkp-1, -2, and -3) facilitate the linkage of desmosome junctional components to each other (e.g. desmosomal cadherins to desmoplakin) and the intermediate-filament cytoskeleton. Pkps also contribute to d
Externí odkaz:
https://doaj.org/article/b91cde92093a48ddb3a19d1492599eea
Autor:
Payam Shahi, Dongsu Park, Adam C Pond, Mamatha Seethammagari, Shin-Heng Chiou, Kyucheol Cho, Julienne L Carstens, William K Decker, Pierre D McCrea, Michael M Ittmann, Jeffrey M Rosen, David M Spencer
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30814 (2012)
Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of Wnt signaling in vivo would be extremely useful. B
Externí odkaz:
https://doaj.org/article/ed933022595d4e3f83612a50ddccaa99
Autor:
William A Munoz, Malgorzata Kloc, Kyucheol Cho, Moonsup Lee, Ilse Hofmann, Amy Sater, Kris Vleminckx, Pierre D McCrea
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34342 (2012)
The p120-catenin family has undergone a significant expansion during the evolution of vertebrates, resulting in varied functions that have yet to be discerned or fully characterized. Likewise, members of the plakophilins, a related catenin subfamily,
Externí odkaz:
https://doaj.org/article/c1af7f4552e2410a91a0734a3344c2a0