RNA G-quadruplex forming regions from SARS-2, SARS-1 and MERS coronoviruses

Autor: Amani Kabbara, Brune Vialet, Julien Marquevielle, Pierre Bonnafous, Cameron D. Mackereth, Samir Amrane

Publikováno v: Frontiers in Chemistry, Vol 10 (2022)

COVID-19 (Corona Virus Disease 2019), SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) are infectious diseases each caused by coronavirus outbreaks. Small molecules and other therapeutics are rapidly being develope

Externí odkaz: https://doaj.org/article/d1a82282ff37483faa5709b567ac8902

Complementary use of mass spectrometry and cryo-electron microscopy to assess the maturity of live attenuated dengue vaccine viruses

Autor: Fabienne Barrière, Frédéric Ronzon, Sergio Marco, Richard J. Kuhn, Mathieu Trauchessec, Pierre Bonnafous, Devika Sirohi, Olivier Lambert, Yves Bérard, Catherine Manin, Victoria Hedrick, Bruno Guy, Celine Huillet

Publikováno v: Vaccine
Vaccine, Elsevier, 2019, 37 (27), pp.3580-3587
Vaccine, Elsevier, 2019, 37 (27), pp.3580-3587. ⟨10.1016/j.vaccine.2019.05.012⟩

Dengue virus (DENV) infection is a global health threat with the potential to affect at least 3.6 billion people living in areas of risk. No specific curative treatments against dengue disease are available and vaccines are currently the only way to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167db3e1730cfe4403ed1bd4ed627f54
https://hal.archives-ouvertes.fr/hal-03182120

A yeast toxic mutant of HET-s amyloid disrupts membrane integrity

Autor: Isabel D. Alves, Sophie Lecomte, Christophe Cullin, Pierre Bonnafous, Bernard Desbat, Karine Berthelot, Ha Phuong Ta, Olivier Lambert, Bénédicte Coulary-Salin, Sabine Castano

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2012, 1818 (9), pp.2325-2334. ⟨10.1016/j.bbamem.2012.04.013⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2012, 1818 (9), pp.2325-34

article i nfo Article history: Many studies have pointed out the interaction between amyloids and membranes, and their potential in- volvement in amyloid toxicity. Previously, we generated a yeast toxic amyloid mutant (M8) from the harm- less amyloid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d1abef3b044521ffb111ab4451f12c
https://doi.org/10.1016/j.bbamem.2012.04.013

Membrane Perturbation and Fusion Pore Formation in Influenza Hemagglutinin-mediated Membrane Fusion

Autor: Toon Stegmann, Pierre Bonnafous

Publikováno v: Journal of Biological Chemistry. 275:6160-6166

Low pH-induced fusion mediated by the hemagglutinin (HA) of influenza virus involves conformational changes in the protein that lead to the insertion of a "fusion peptide" domain of this protein into the target membrane and is thought to perturb the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d20a3be7bb9ccc4a719ae1a35f58654
https://doi.org/10.1074/jbc.275.9.6160

Hepatitis B subvirus particles display both a fluid bilayer membrane and a strong resistance to freeze drying: a study by solid-state NMR, light scattering, and cryo-electron microscopy/tomography

Autor: Frédéric Ronzon, Paul Guichard, Pierre Bonnafous, Sergio Marco, Axelle Grélard, Erick J. Dufourc, Olivier Lambert, Catherine Manin

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2013, 27 (10), pp.4316-4326. ⟨10.1096/fj.13-232843⟩

Hepatitis B surface antigen (HBsAg) subvirus particles produced from yeast share immunological determinants with mature viruses, which enable the use of HBsAg as a potent antigen for human vaccination. Because the intimate structure of such pseudovir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1710b57087ab1ba671f4f133cc6f7ee4
https://hal.archives-ouvertes.fr/hal-02123972