Výsledky vyhledávání - "Pierre Bischoff"

Combination of the mTOR inhibitor RAD001 with temozolomide and radiation effectively inhibits the growth of glioblastoma cells in culture

Autor: Pierre Bischoff, Hélène Burckel, Georges Noël, Jean-Marc Denis, John Gueulette, Jakobus Slabbert, Elodie Josset

Publikováno v: Oncology Reports. 33:471-477

The present in vitro study aimed to assess the effects of combining the mTOR inhibitor RAD001 and temozolomide (TMZ) together with irradiation by either low-linear energy transfer (LET) radiation (γ-rays) or high-LET radiation (fast neutrons) on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fa64f6da7e87196c2378e805fb454a
https://doi.org/10.3892/or.2014.3590

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Disrupting the mTOR Signaling Network as a Potential Strategy for the Enhancement of Cancer Radiotherapy

Autor: Pierre Bischoff, Francis Dumont

Publikováno v: Current Cancer Drug Targets. 12:899-924

Radiotherapy (RT) allows for tumor control through the cytotoxic action of ionizing radiation (IR). Although modern technologies permit precise IR delivery to the tumor mass while minimizing exposure of surrounding healthy tissues, the efficacy of RT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1883b1f263b2e5f5d1b114383b937c0
https://doi.org/10.2174/156800912803251243

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Novel pharmacological modulators of autophagy and therapeutic prospects

Autor: Elodie Josset, Pierre Bischoff, Francis Dumont

Publikováno v: Expert Opinion on Therapeutic Patents. 22:1053-1079

Autophagy is an intracellular process of self-digestion involving the lysosomal degradation of cytoplasmic organelles and macromolecules. It occurs at low basal levels to perform housekeeping functions and is dramatically augmented upon nutrient depl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0180f6cbeb2a3bf5036d219e8fa9021d
https://doi.org/10.1517/13543776.2012.715148

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Evaluation of the Radioprotective Potential of the Polyphenol Norbadione A

Autor: Thierry Le Gall, Stéphane Meunier, Frédéric Taran, Sami Benzina, Elodie Josset, Brice Nadal, Antoine Le Roux, Marine Desage-El Murr, Pierre Bischoff, Benoit Heurtaux, Jean-Marc Denis

Publikováno v: Letters in Drug Design & Discovery. 9:48-53

There is an obvious need to develop efficient countermeasure agents for use in emergency situations or as adjuncts to radiotherapy to protect healthy tissues from the consequences of an irradiation. To this end, we have investigated the capacity of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd025143c7c31a77d0f962c971ed2999
https://doi.org/10.2174/157018012798192900

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Design and Synthesis of New Antioxidants Predicted by the Model Developed on a Set of Pulvinic Acid Derivatives

Autor: Alain Wagner, Thierry Le Gall, Stéphane Meunier, Pierre Bischoff, Damien Habrant, Igor Kuzmanovski, Sophie A.-L. Thetiot-Laurent, Antoine Le Roux, Marjana Novič, Brice Nadal

Publikováno v: Journal of Chemical Information and Modeling. 51:3050-3059

Antioxidative activity expressed as protection of thymidine has been investigated for a set of 30 pulvinic acid derivatives. A combination of in vitro testing and in silico modeling was used for synthesis of new potential antioxidants. Experimental d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae58c062dff7f06717863135d243d0a
https://doi.org/10.1021/ci200205d

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