Výsledky vyhledávání - "Pierre Bedoucha"

Visual exploration of large normal mode spaces to study protein flexibility

Autor: Jan Byška, Helwig Hauser, Pierre Bedoucha, Nathalie Reuter

Publikováno v: Computers & graphics

When studying the function of proteins, biochemists utilize normal mode decomposition to enable the analysis of structural changes on time scales that are too long for molecular dynamics simulation. Such a decomposition yields a high-dimensional para

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4b81c0812224a2b827938acb46718b
https://doi.org/10.1016/j.cag.2020.05.025

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Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases

Autor: Jan Byška, Nathalie Reuter, Angèle Abboud, Thomas Arnesen, Pierre Bedoucha

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 532-547 (2020)

Graphical abstract
N-terminal acetyltransferases (NATs) belong to the superfamily of acetyltransferases. They are enzymes catalysing the transfer of an acetyl group from acetyl coenzyme A to the N-terminus of polypeptide chains. N-terminal acety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694de509c94a1ec057001a596b857080
https://hdl.handle.net/11250/2754693

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Dynamics-function relationship of N-terminal acetyltransferases: the β6β7 loop modulates substrate accessibility to the catalytic site

Autor: Pierre Bedoucha, Angèle Abboud, Jan Byška, Thomas Arnesen, Nathalie Reuter

N-terminal acetyltransferases (NATs) are enzymes catalysing the transfer of the acetyl from Ac-CoA to the N-terminus of proteins, one of the most common protein modifications. Unlike NATs, lysine acetyltransferases (KATs) transfer an acetyl onto the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51e491abe37603e57d138b7fbef502e

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Substitutions at residue 211 in the prion protein drive a switch between CJD and GSS syndrome, a new mechanism governing inherited neurodegenerative disorders

Autor: Etienne Levavasseur, Jean-Louis Laplanche, Philippe Derreumaux, Human Rezaei, Céline Chapuis, Nicolas Privat, Katell Peoc'h, M. Borg, Isabelle Laffont-Proust, Pierre Bedoucha, Yassmine Chebaro, Annie Laquerrière, Stéphane Haïk, Jean-Jacques Hauw, Alfonso De Simone, Jean-Louis Kemeny, Jean-Philippe Brandel, Emilien Delmont

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2012, 21 (26), pp.5417--5428. ⟨10.1093/hmg/dds377⟩
Human Molecular Genetics 26 (21), 5417-5428. (2012)
Human Molecular Genetics, Oxford University Press (OUP), 2012, 21 (26), pp.5417--5428. ⟨10.1093/hmg/dds377⟩
Hum. Mol. Genet.
Hum. Mol. Genet., 2012, 21 (26), pp.5417--5428. 〈10.1093/hmg/dds377〉

Human prion diseases are a heterogeneous group of fatal neurodegenerative disorders, characterized by the deposition of the partially protease-resistant prion protein (PrPres), astrocytosis, neuronal loss and spongiform change in the brain. Among inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e351c19f516b7b777c862ed92ede2cc
https://hal.science/hal-01498095/document

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Akademický článek

Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases

Autor: Angèle Abboud, Pierre Bédoucha, Jan Byška, Thomas Arnesen, Nathalie Reuter

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 532-547 (2020)

N-terminal acetyltransferases (NATs) belong to the superfamily of acetyltransferases. They are enzymes catalysing the transfer of an acetyl group from acetyl coenzyme A to the N-terminus of polypeptide chains. N-terminal acetylation is one of the mos

Externí odkaz: https://doaj.org/article/c0bab6a947cb4e70817490881c617cf5

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