Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pierre Beauparlant"'
Skeletal Effects of Bone-Targeted TGFbeta Inhibition in a Mouse Model of Duchenne Muscular Dystrophy
Publikováno v:
Life, Vol 11, Iss 8, p 791 (2021)
Duchenne muscular dystrophy (DMD) is a severe progressive muscle disease that is frequently associated with secondary osteoporosis. Previous studies have shown that TGFbeta inactivating antibody improves the muscle phenotype in mdx mice, a model of D
Externí odkaz:
https://doaj.org/article/24208329d2b14873ae244265c532653f
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 2, Iss 3, Pp 109-115 (1991)
Polymorphic B cell lymphoma and diffuse B cell lymphoproliferation associated with Epstein-Barr virus infection is increasingly reported in immunodeficient patients. Accurate diagnosis of these pathologies is essential because the appropriate treatme
Externí odkaz:
https://doaj.org/article/746f3b06e8384f378354c78e5cf62b30
Autor:
Pierre Beauparlant, Amani Khorchid
Publikováno v:
Expert Opinion on Therapeutic Patents. 14:805-818
The antiapoptotic members of the Bcl-2 family of proteins play multiple roles in cancer. These membrane-integrated proteins inhibit the pro-apoptotic activity of oncogenes during oncogenesis, support the survival of established cancer cells, and incr
Autor:
Pierre Beauparlant, Gang Chen, Alexei Yu. Denisov, Abdelkrim Khadir, Giorgio Attardo, Gordon C. Shore, S.R. Murthy Madiraju, Kalle Gehring
Publikováno v:
Journal of Biological Chemistry. 278:21124-21128
The structure of human BCL-w, an anti-apoptotic member of the BCL-2 family, was determined by triple-resonance NMR spectroscopy and molecular modeling. Introduction of a single amino acid substitution (P117V) significantly improved the quality of the
Publikováno v:
Seminars in Arthritis and Rheumatism. 29:148-158
Objectives: The treatment of rheumatoid arthritis (RA) targets inflammationeither by inhibiting the activation of immune cells or their clonal expansion. We evaluated the available evidence concerning the risk of cancer associated with RA treatment.
Publikováno v:
Virology. 234(2):277-290
Oxidative stress activates the NF-kappaB/Rel transcription factors which are involved in the activation of numerous immunoregulatory genes and the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). In the present study, we examin
Autor:
Pierre Beauparlant, Carmela DeLuca, Hakju Kwon, Louisa Petropoulos, Pascale Crépieux, Rongtuan Lin, John Hiscott
Publikováno v:
Journal of Leukocyte Biology. 62:82-92
NF-kappa B/Rel transcription factors participate in the activation of numerous genes involved in immune regulation/inflammation including cytokines, cell surface receptors, adhesion molecules, and acute phase proteins. NF-kappa B activity is controll
Publikováno v:
Journal of Biological Chemistry. 271:10690-10696
In the present study, the role of the IκBα C terminus in NF-κB/IκBα regulation was examined in NIH 3T3 cells engineered to inducibly express wild type or mutated human IκBα proteins under the control of the tetracycline responsive promoter. De
Autor:
Xavier Billot, Michel-Olivier Gratton, Manon Lavoie, Michael Lawless, Kenza Dairi, Gordon C. Shore, Cynthia Bernier, Mai Nguyen, Anne Roulston, Pierre Beauparlant, Karine Gilbert, Helen M. Chan, Henady Isakau, Daniel Goulet, Denis Paquette, Abdelkrim Khadir, Alvin Berger, Richard C. Marcellus, Dominique Bédard, Anne Jang, Emilie Turcotte, Laurent Bélec, Stephane Branchaud, Elizabeth Koch, Matthew W. Mitchell, Mark F. Watson
GMX1777 is a prodrug of the small molecule GMX1778, currently in phase I clinical trials for the treatment of cancer. We describe findings indicating that GMX1778 is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme nicotinamide phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b8a3de94442e61e49a10ce45e1a472
https://europepmc.org/articles/PMC2772749/
https://europepmc.org/articles/PMC2772749/
Autor:
Xavier Billot, Jean Viallet, Enrico O. Purisima, Ricky W. Johnstone, Leonie A. Cluse, Daniel Goulet, Laurent Bélec, Stephane Acoca, Anne Roulston, Lucile Serfass, Gordon C. Shore, Mark F. Watson, S.R. Murthy Madiraju, Adrian Wiegmans, Richard C. Marcellus, Mai Nguyen, Pierre Beauparlant
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(49)
Elevated expression of members of the BCL-2 pro-survival family of proteins can confer resistance to apoptosis in cancer cells. Small molecule obatoclax (GX15-070), which is predicted to occupy a hydrophobic pocket within the BH3 binding groove of BC