Dynamic Crystallization Pathways of Polymorphic Pharmaceuticals Revealed in Segmented Flow with Inline Powder X-ray Diffraction

Autor: Mark A. Levenstein, Fiona C. Meldrum, Chick C. Wilson, Lois E. Wayment, Chiu C. Tang, Pierre-Baptiste Flandrin, Ruth A. Lunt, Karen Robertson, C. Daniel Scott, Sarah J. Day, Nikil Kapur

Publikováno v: Analytical Chemistry

Understanding the transitions between polymorphs is essential in the development of strategies for manufacturing and maximizing the efficiency of pharmaceuticals. However, this can be extremely challenging: crystallization can be influenced by subtle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22588b7845c22e1efe54735eab9ee2c1
https://doi.org/10.1021/acs.analchem.0c00860

Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

Autor: Pierre-Baptiste Flandrin, Chick C. Wilson, Anneke R. Klapwijk, Karen Robertson

Publikováno v: Robertson, K, Flandrin, P-B, Klapwijk, A R & Wilson, C C 2016, ' Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC) ', Crystal Growth and Design, vol. 16, no. 8, pp. 4759-4764 . https://doi.org/10.1021/acs.cgd.6b00885

The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e393cf3f4379b4218805be10bcef2b95
https://doi.org/10.1021/acs.cgd.6b00885