Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Pierre Baillargeon"'
Autor:
Emery Smith, Meredith E. Davis-Gardner, Ruben D. Garcia-Ordonez, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Xuerong Yu, Thomas D. Bannister, Pierre Baillargeon, Louis Scampavia, Patrick Griffin, Michael Farzan, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 28, Iss 3, Pp 95-101 (2023)
The SARS coronavirus 2 (SARS-CoV-2) pandemic remains a major problem in many parts of the world and infection rates remain at extremely high levels. This high prevalence drives the continued emergence of new variants, and possibly ones that are more
Externí odkaz:
https://doaj.org/article/db1e32100b2d4082831f28774739da29
Autor:
Virneliz Fernández Vega, Dong Yang, Luis Ortiz Jordán, Fei Ye, Louis Conway, Li Yun Chen, Justin Shumate, Pierre Baillargeon, Louis Scampavia, Christopher Parker, Ben Shen, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 28, Iss 2, Pp 20-28 (2023)
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and accounts for ∼84% of all lung cancer cases. NSCLC remains one of the leading causes of cancer-associated death, with a 5-year survival rate less than 25%. This type of ca
Externí odkaz:
https://doaj.org/article/3e49c444351c49eaa92e3aaa15039015
Autor:
Pierre Baillargeon, Virneliz Fernandez-Vega, Luis Ortiz, Justin Shumate, Nicholas Marques, Lynn Deng, Timothy P. Spicer, Louis Scampavia
Publikováno v:
SLAS Technology, Vol 27, Iss 3, Pp 180-186 (2022)
Open-source projects continue to grow in popularity alongside open-source educational resources, software, and hardware tools. The impact of this increased availability of open-source technologies is that end users are empowered to have greater contr
Externí odkaz:
https://doaj.org/article/496d72c703974aa98b0f0e3ea4ab4901
Autor:
Emery Smith, Sean Campbell, Adrianna N. Wilson, Justin Shumate, Pierre Baillargeon, Louis Scampavia, Theodore M. Kamenecka, Timothy P. Spicer, Laura A. Solt
Publikováno v:
SLAS Discovery, Vol 27, Iss 4, Pp 242-248 (2022)
NR2F6 is considered an orphan nuclear receptor since its endogenous ligand has yet to be identified. Recently, NR2F6 has emerged as a novel cancer therapeutic target. NR2F6 has been demonstrated to be upregulated or overexpressed in several cancers.
Externí odkaz:
https://doaj.org/article/b2cb804dfe0248e8b899f1f4ec42e127
Autor:
Virneliz Fernandez-Vega, Shurong Hou, Dennis Plenker, Hervé Tiriac, Pierre Baillargeon, Justin Shumate, Louis Scampavia, Jan Seldin, Glauco R. Souza, David A. Tuveson, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 27, Iss 3, Pp 159-166 (2022)
Recent technological advances have enabled 3D tissue culture models for fast and affordable HTS. We are no longer bound to 2D models for anti-cancer agent discovery, and it is clear that 3D tumor models provide more predictive data for translation of
Externí odkaz:
https://doaj.org/article/dd3207bcac4340e9bc086866d293919b
Autor:
Sumitha Rajendra Rao, Ana Kostic, Pierre Baillargeon, Virneliz Fernandez-Vega, Mitzy Rios de Anda, Kelty Fletcher, Justin Shumate, Louis Scampavia, Joseph D Buxbaum, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 27, Iss 2, Pp 128-139 (2022)
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder. There are no drugs to treat the core symptoms. De novo mutations often play an important role in ASD and multiple high-risk loci have been identified in the last decade. T
Externí odkaz:
https://doaj.org/article/59646419ec504c02ac04a5716e2fac39
Autor:
Sonia Mediouni, Huihui Mou, Yuka Otsuka, Joseph Anthony Jablonski, Robert Scott Adcock, Lalit Batra, Dong-Hoon Chung, Christopher Rood, Ian Mitchelle S. de Vera, Ronald Rahaim Jr., Sultan Ullah, Xuerong Yu, Yulia A. Getmanenko, Nicole M. Kennedy, Chao Wang, Tu-Trinh Nguyen, Mitchell Hull, Emily Chen, Thomas D. Bannister, Pierre Baillargeon, Louis Scampavia, Michael Farzan, Susana T. Valente, Timothy P. Spicer
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 8-19 (2022)
The severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 remains a persistent threat to mankind, especially for the immunocompromised and elderly for which the vaccine may have limited effectiveness. Entry of SARS-CoV-2 requires a
Externí odkaz:
https://doaj.org/article/2347b83126774a29aab28c5d045a7718
Polar crystal of vanillylformamide through replacement of the alkene by an isosteric formamide group
Publikováno v:
IUCrData, Vol 3, Iss 12, p x181630 (2018)
Vanillylformamide [systematic name: N-(4-hydroxy-3-methoxybenzyl)formamide], C9H11NO3, (II), has been synthesized from vanillylamine hydrochloride and studied by single-crystal X-ray diffraction. Compound (II) and the well known biologically active e
Externí odkaz:
https://doaj.org/article/ea6113bb4ea640178d8eca52c95b3e6b
Autor:
Yves L. Dory, Mia Caron, Vincent Olivier Duguay, Lucas Chicoine-Ouellet, Daniel Fortin, Pierre Baillargeon
Publikováno v:
Crystals, Vol 9, Iss 9, p 448 (2019)
Crystal structure elucidations of bio-based polymers provide invaluable data regarding structure−property relationships. In this work, we achieved synthesis and Single Crystal X-ray Diffraction (SCXRD) structural determination of a new furan-based
Externí odkaz:
https://doaj.org/article/1d8da6049ae0428db325709bd59910f6
Publikováno v:
Crystals, Vol 6, Iss 4, p 37 (2016)
Isomorphous crystals of two diacetylene derivatives with carbamate functionality (BocNH-CH2-diyne-X, where X = H or Br) have been obtained. The main feature of these structures is the original 2D arrangement (as supramolecular sheets or walls) in whi
Externí odkaz:
https://doaj.org/article/0f5d5f95038d457d9908e20af1d65b8e