Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pierre Bélichard"'
Autor:
Jean Martinez, Monique Calmes, Didier Pruneau, Isabelle Daffix, Muriel Amblard, Pierre Bélichard, Pierre Dodey, Jean-Luc Paquet, Gilbert Bergé, Jean-Michel Luccarini
Publikováno v:
Journal of Medicinal Chemistry. 42:4193-4201
We have previously shown that substitution of the D-Tic-Oic dipeptide by a (3S)-[amino]-5-(carbonylmethyl)-2,3-dihydro-1, 5-benzothiazepin-4(5H)-one (D-BT) moiety in the bradykinin B(2) receptor antagonist HOE 140 resulted in a full potent and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdb681fd38cee46725c5e66488a959e
https://doi.org/10.1021/jm9901531
https://doi.org/10.1021/jm9901531
Autor:
Jean Martinez, Pierre Bélichard, Jean-Luc Paquet, Pierre Dodey, Didier Pruneau, Gilbert Bergé, Isabelle Daffix, Philippe Bedos, Muriel Amblard, Jean-Michel Luccarini
Publikováno v:
Journal of Medicinal Chemistry. 42:4185-4192
A bradykinin analogue (H-Arg-Pro-Pro-Gly-Phe-Ser-D-BT-Arg-OH, 3) in which the Pro-Phe dipeptide was replaced by the (3S)[amino]-5-(carbonylmethyl)-2,3-dihydro-1, 5-benzothiazepin-4(5H)-one (D-BT) moiety has been synthesized. The same modification was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1c133b8ba3c3e1b1343a027cbfa637
https://doi.org/10.1021/jm9901529
https://doi.org/10.1021/jm9901529
Autor:
Bruno Loillier, Pierre Bélichard, Chantal Fouchet, Jean Luc Paquet, Jean-Michel Luccarini, Pierre Dodey, Evelyne Defrêne, Claude Robert, Didier Pruneau, Rose-Marie Franck, Béatrice Cremers, Hervé Duclos
Publikováno v:
Immunopharmacology. 43:187-194
LF 16-0687 (1-[[2,4-dichloro-3-[[(2,4-dimethylquinolin-8-yl)oxy] methyl]phenyl]sulfonyl]-N-[3-[[4-(aminoimethyl) phenyl] carbonylamino]propyl]-2(S)-pyrrolidinecarboxamide) has been selected from a large-scale medicinal chemistry program for further d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee18234ecabe0be5c7556c07fd24f22
https://doi.org/10.1016/s0162-3109(99)00128-9
https://doi.org/10.1016/s0162-3109(99)00128-9
Autor:
P. Faye, Evelyne Defrêne, Hervé Duclos, Jean-Luc Paquet, Jean-Michel Luccarini, Rose-Marie Franck, Didier Pruneau, Pierre Bélichard
Publikováno v:
British Journal of Pharmacology. 128:213-219
1. In the present study, we developed an experimental model of cystitis induced by cyclophosphamide (CYP). In order to characterize des-Arg9-BK-induced contraction on the urinary bladder (UB) during the development of inflammation and to quantify kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273d5630fe10cf9a7c3eb3c7c18007b9
https://doi.org/10.1038/sj.bjp.0702769
https://doi.org/10.1038/sj.bjp.0702769
Autor:
Pierre Bélichard, Didier Pruneau, Bruno Loillier, Evelyne Defrêne, Béatrice Cremers, Claude Robert, Chantal Fouchet, Jean-Luc Paquet, Jean-Michel Luccarini
Publikováno v:
British Journal of Pharmacology. 126:1083-1090
The present study addresses the differences in binding profiles and functional properties of the human and rat bradykinin (BK) B2 receptor using various kinin receptor peptide derivatives as well as the non-peptide receptor antagonists WIN 64338 (pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf87638472c635b4e48c384b96f4418
https://doi.org/10.1038/sj.bjp.0702403
https://doi.org/10.1038/sj.bjp.0702403
Autor:
Chantal Fouchet, Evelyne Defrêne, Rose-Marie Franck, Jean-Michel Luccarini, Didier Pruneau, Pierre Bélichard, Béatrice Cremers, Claude Robert, Jean-Luc Paquet, Bruno Loillier, Hervé Duclos
Publikováno v:
Fundamental & Clinical Pharmacology. 13:75-83
Activation of the kinin-kallikrein system and stimulation of bradykinin (BK) B2 receptors are thought to play an important role in the pathophysiology of inflammation and pain. In the present study, we report the pharmacological properties of a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f55a478c77ef8d7e308342c207256c
https://doi.org/10.1111/j.1472-8206.1999.tb00323.x
https://doi.org/10.1111/j.1472-8206.1999.tb00323.x
Autor:
Jean-Luc Paquet, Jean-Michel Luccarini, Evelyne Defrêne, Chantal Fouchet, Hervé Duclos, Béatrice Cremers, Claude Robert, Didier Pruneau, Pierre Bélichard, Bruno Loillier, Rose-Marie Franck
Publikováno v:
British Journal of Pharmacology. 125:365-372
1. In the present paper, we describe the in vitro pharmacological properties of LF 16.0335 (1-[[3-[(2,4-dimethylquinolin-8-yl)oxymethyl]-2,4-dichloro-p henyl]sulphonyl] -2(S) - [[4 -[4-(aminoiminomethyl)phenylcarbonyl]piperazin-1-yl]ca rbonyl]pyrroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc4682bd8ca1233bb963173baf4755e
https://doi.org/10.1038/sj.bjp.0702083
https://doi.org/10.1038/sj.bjp.0702083
Publikováno v:
British Journal of Pharmacology. 117:1565-1571
1. Mongrel dogs were chronically instrumented with an intra-aortic catheter, a Konigsberg intraventricular pressure transducer and a Doppler flow probe around the left coronary artery. After ganglionic blockade with hexamethonium, the cardiovascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dc24aeac909c9cecf273fddcb410cc
https://doi.org/10.1111/j.1476-5381.1996.tb15322.x
https://doi.org/10.1111/j.1476-5381.1996.tb15322.x
Publikováno v:
European Journal of Pharmacology. 297:53-60
Coronary artery rings from juvenile male farm pigs were incubated for 6 h and precontracted with U46619. The rings relaxed in response to des-Arg 9 -bradykinin (pD 2 , 7.78 ± 0.13; E max , 87.4 ± 4.3%) and to bradykinin (pD 2 , 8.69 ± 0.30; E max
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518d66a28e0bfd08d6d7d668509d7827
https://doi.org/10.1016/0014-2999(95)00720-2
https://doi.org/10.1016/0014-2999(95)00720-2
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 11(5)
Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus that can lead to visual impairment and blindness. There is no approved pharmacological treatment for DR; however, laser therapy, steroids and anti-VEGF agents appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ad111215033038d10623dd4761ff2fc
https://pubmed.ncbi.nlm.nih.gov/20419596
https://pubmed.ncbi.nlm.nih.gov/20419596