Targeting the Brain with Single-Domain Antibodies: Greater Potential Than Stated So Far?

Autor: Mireille Elodie Tsitokana, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin, Philippe Rondard

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 3, p 2632 (2023)

Treatments for central nervous system diseases with therapeutic antibodies have been increasingly investigated over the last decades, leading to some approved monoclonal antibodies for brain disease therapies. The detection of biomarkers for diagnosi

Externí odkaz: https://doaj.org/article/5b6cddb357dd419e97960d36725e317d

Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain

Autor: Jiyong Meng, Chanjuan Xu, Pierre-André Lafon, Salomé Roux, Michaël Mathieu, Rui Zhou, Pauline Scholler, Emilie Blanc, Jérôme A. J. Becker, Julie Le Merrer, Javier González-Maeso, Patrick Chames, Jianfeng Liu, Jean-Philippe Pin, Philippe Rondard

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, 2022, 18, pp.894-903. ⟨10.1038/s41589-022-01050-2⟩

International audience; Membrane proteins, including ion channels, receptors and transporters, are often composed of multiple subunits and can form large complexes. Their specific composition in native tissues is difficult to determine and remains la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047b294d11390a4ebb7d45c816ec59d6
https://hal.science/hal-03699580/document

Prenatal exposure to low doses of fungicides corrupts neurogenesis in neonates

Autor: Lucie Salvador-Prince, Joan Torrent, Jianfeng Liu, Françoise Trousse, Pierre-André Lafon, Yunyun Wang, Véronique Perrier, Corinne Prévostel, Carole Crozet, Aroa Relano Gines

Publikováno v: Environmental Research
Environmental Research, Elsevier, 2021, 195, pp.110829. ⟨10.1016/j.envres.2021.110829⟩

International audience; Neurogenesis plays a crucial role during neurodevelopment and its dysfunction can lead to neurodevelopmental disorders. A recent hypothesis stipulates that exogenous factors could corrupt this process and predispose to neurode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72c55a487e7e56412b61d7efc520e40
https://www.hal.inserm.fr/inserm-03334138/document

Fungicide Residues Exposure and β-amyloid Aggregation in a Mouse Model of Alzheimer’s Disease

Autor: Laurent Givalois, Margarita Arango-Lievano, Josep V. Mercader, Marine Mansuy, Freddy Jeanneteau, Lucie Salvador-Prince, Catherine Desrumaux, Joan Torrent, Nadine Mestre-Francés, Pierre-André Lafon, Véronique Perrier, Jianfeng Liu, Yunyun Wang

Publikováno v: Environmental Health Perspectives
Environmental Health Perspectives, 2020, 128 (1), pp.017011. ⟨10.1289/EHP5550⟩
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2020, 128 (1), pp.017011. ⟨10.1289/EHP5550⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Background: Pesticide residues have contaminated our environment and nutrition over the last century. Although these compounds are present at very low concentrations, their long-term effects on human health is of concern. The link between pesticide r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c44e80b7bef0bf29aae1cccd237dc7
https://doi.org/10.1289/EHP5550

Low doses of bioherbicide favour prion aggregation and propagation in vivo

Autor: Maria-Teresa Alvarez-Martinez, Elisabeth Huetter, Mike Robitzer, Thibaut Imberdis, Pierre-André Lafon, Nathalie Chevallier, Jianfeng Liu, Véronique Perrier, Catherine Desrumaux, Joan Torrent, Yunyun Wang, Laurent Givalois

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8 (1), 〈10.1038/s41598-018-25966-9〉
Scientific Reports, Nature Publishing Group, 2018, 8 (1), pp.8023. ⟨10.1038/s41598-018-25966-9⟩
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, 2018, 8 (1), pp.8023. ⟨10.1038/s41598-018-25966-9⟩
Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-25966-9⟩

Public concerns over the use of synthetic pesticides are growing since many studies have shown their impact on human health. A new environmental movement in occidental countries promoting an organic agriculture favours the rebirth of botanical pestic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3a546e6f20e861b42a3d2fe2193863
https://hal.umontpellier.fr/hal-01810986