MG132‐induced progerin clearance is mediated by autophagy activation and splicing regulation

Autor: Karim Harhouri, Claire Navarro, Danielle Depetris, Marie‐Geneviève Mattei, Xavier Nissan, Pierre Cau, Annachiara De Sandre‐Giovannoli, Nicolas Lévy

Publikováno v: EMBO Molecular Medicine, Vol 9, Iss 9, Pp 1294-1313 (2017)

Abstract Hutchinson–Gilford progeria syndrome (HGPS) is a lethal premature and accelerated aging disease caused by a de novo point mutation in LMNA encoding A‐type lamins. Progerin, a truncated and toxic prelamin A issued from aberrant splicing,

Externí odkaz: https://doaj.org/article/3dccc1a6bece434b9ffa140170f11a46

MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells

Autor: Lévy, Karim Harhouri, Pierre Cau, Frank Casey, Koffi Mawuse Guedenon, Yassamine Doubaj, Lionel Van Maldergem, Gerardo Mejia-Baltodano, Catherine Bartoli, Annachiara De Sandre-Giovannoli, Nicolas

Publikováno v: Cells; Volume 11; Issue 4; Pages: 610

Progeroid syndromes (PS), including Hutchinson-Gilford Progeria Syndrome (HGPS), are premature and accelerated aging diseases, characterized by clinical features mimicking physiological aging. Most classical HGPS patients carry a de novo point mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::31b95442193acb568e6d489f8858cb75

MG132 induces progerin clearance and improves disease phenotypes in fibroblasts of patients affected with Hutchinson-Gilford Progeria-like syndromes

Autor: De Sandre-Giovannoli A, Karim Harhouri, Nicolas Lévy, Mawuse Gk, Van Maldergem L, Pierre Cau, Casey F, Yassamine Doubaj, Mejia-Baltodano G

Progeroid Syndromes (PS), including Hutchinson-Gilford Progeria Syndrome (HGPS, OMIM #176670), are premature and accelerated aging that clinically resemble some aspects of advancing physiological aging. Most classical HGPS patients carry a de novo po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f21267cf649bdabeb4f9cf4ee6a92326
https://doi.org/10.1101/2021.04.14.439612

HIV-1 infection and first line ART induced differential responses in mitochondria from blood lymphocytes and monocytes: the ANRS EP45 'Aging' study.

Autor: Sophie Perrin, Jonathan Cremer, Patrice Roll, Olivia Faucher, Amélie Ménard, Jacques Reynes, Pierre Dellamonica, Alissa Naqvi, Joëlle Micallef, Elisabeth Jouve, Catherine Tamalet, Caroline Solas, Christel Pissier, Isabelle Arnoux, Corine Nicolino-Brunet, Léon Espinosa, Nicolas Lévy, Elise Kaspi, Andrée Robaglia-Schlupp, Isabelle Poizot-Martin, Pierre Cau

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41129 (2012)

The ANRS EP45 "Aging" study investigates the cellular mechanisms involved in the accelerated aging of HIV-1 infected and treated patients. The data reported focus on mitochondria, organelles known to be involved in cell senescence.49 HIV-1 infected p

Externí odkaz: https://doaj.org/article/97b55a40e0714b9e9dd9845210e6f4f2

Identification of CD146 as a novel molecular actor involved in systemic sclerosis

Autor: Elise Kaspi, Brigitte Granel, Alexandrine Bertaud-Foucault, Benjamin Guillet, Andrée Robaglia-Schlupp, Richard Bachelier, Audrey Benyamine, Aurélie S. Leroyer, Marie Nollet, Marcel Blot-Chabaud, Patrice Roll, Nathalie Bardin, Xavier Heim, Pierre Cau, Jimmy Stalin, Françoise Dignat-George

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2017, 140 (5), pp.1448-1451.e6. ⟨10.1016/j.jaci.2017.04.046⟩
Journal of Allergy and Clinical Immunology, Elsevier, 2017, 140 (5), pp.1448-1451.e6. ⟨10.1016/j.jaci.2017.04.046⟩

International audience; We highlight for the first time that CD146/sCD146 is involved in fibrotic process during SSc. sCD146 could thus constitute a new biomarker to assess disease activity, and potentially a new target for therapeutic applications.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0110341d6ab3706d62aabf45a2462de
https://hal-amu.archives-ouvertes.fr/hal-01778289/file/Kaspietal13092016-1.pdf