Výsledky vyhledávání - "Pierre, van de Weghe"

Ex vivo potential of a quinoline-derivative nail lacquer as a new alternative for dermatophytic onychomycosis treatment

Autor: Marilene Henning Vainstein, Pierre van de Weghe, Denise Diedrich, Simone Jacobus Berlitz, Alexandre Meneghello Fuentefria, Simone Cristina Baggio Gnoatto, Bruna Pippi, Mickael Jean, Diego Defferrari, Gabriella da Rosa Monte Machado, Irene Clemes Külkamp-Guerreiro, William Lopes, Saulo Fernandes de Andrade

Publikováno v: Journal of Medical Microbiology
Journal of Medical Microbiology, 2021, 70 (3), ⟨10.1099/jmm.0.001314⟩
Journal of Medical Microbiology, Society for General Microbiology, 2021, 70 (3), ⟨10.1099/jmm.0.001314⟩

Introduction. Onychomycosis infections currently show a significant increase, affecting about 10 % of the world population. Trichophyton rubrum is the main agent responsible for about 80 % of the reported infections. The clinical cure for onychomycos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab71854918f288083e91bc57343e495f
https://hal.science/hal-03128571

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Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis

Autor: Aline Rigon Zimmer, Thaís Carine Ruaro, Denise Diedrich, Luís Flávio de Oliveira, Simone Cristina Baggio Gnoatto, Pierre van de Weghe, Mickael Jean, Gabriella da Rosa Monte Machado, Mário Lettieri Teixeira, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefria

Publikováno v: Brazilian Journal of Microbiology
Brazilian Journal of Microbiology, 2020, 51 (4), pp.1691-1701. ⟨10.1007/s42770-020-00348-4⟩
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS

Fungal infections have emerged as a current serious global public health problem. The main problem involving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes neces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7da3e25932812865fbfd15965f1e8e
https://hal.science/hal-04022492

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Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics

Autor: Annie Trautwetter, Gwennola Ermel, Cédric Tresse, Jean-Christophe Giard, Carlos Blanco, Richard Radigue, Pierre van de Weghe, Marion Thepaut, Reynald Gillet, Rafael Gomes Von Borowski, Fanny Demay, Sylvie Georgeault, Hong Hanh Le, Anne Dhalluin, Mickael Jean

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2019, 27 (21), pp.115097. ⟨10.1016/j.bmc.2019.115097⟩
Bioorganic and Medicinal Chemistry, 2019, 27 (21), pp.115097. ⟨10.1016/j.bmc.2019.115097⟩

International audience; The reality and intensity of antibiotic resistance in pathogenic bacteria calls for the rapid development of new antimicrobial drugs. In bacteria, trans-translation is the primary quality control mechanism for rescuing ribo-so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96263e23fce8806427c623386b810d3
https://hal-normandie-univ.archives-ouvertes.fr/hal-02863493

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Probing the side chain tolerance for inhibitors of the CD95/PLCγ1 interaction

Autor: Patrick Legembre, Ha Thanh Nguyen, Jean-Philippe Guégan, Pierre van de Weghe, Nicolas Levoin, Daniel Best, Mickael Jean

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (21), pp.126669. ⟨10.1016/j.bmcl.2019.126669⟩

International audience; Proceeding our effort to study protein-protein interaction between the death receptor CD95 and phospholipase PLCγ1, we present in the current work chameleon-like traits of peptidomimetic inhibitors. Minute analysis of the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6440654ce8d4addb18bce2521534b3f
https://univ-rennes.hal.science/hal-02393634

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Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells

Autor: Hariniaina Rampanarivo, Mickael Jean, Amélie Fouqué, Patrick Legembre, Mac Dinh Hung, Kenji F. Shoji, Yves Collette, Marine Malleter, Rémy Castellano, Emmanuelle Josselin, Pierre van de Weghe, Olivier Delalande

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2019, 62 (20), pp.9339-9340. ⟨10.1021/acs.jmedchem.9b01578⟩
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (20), pp.9339-9340. ⟨10.1021/acs.jmedchem.9b01578⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3458dce9a9baf7d4d7aeec3ee6a28286
https://hal.science/hal-02526957

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Lichen butyrolactone derivatives disrupt oral bacterial membrane

Autor: Agnès Burel, Marylène Chollet-Krugler, Julien Vallet, Ali Chokr, Alaa Sweidan, Zohreh Tamanai-Shacoori, Latifa Bousarghin, Nolwenn Oliviero, Aurélie Sauvager, Sophie Tomasi, Nicolas Gouault, Pierre van de Weghe, Imen Smida

Publikováno v: Fitoterapia
Fitoterapia, Elsevier, 2019, 137, pp.104274. ⟨10.1016/j.fitote.2019.104274⟩
Fitoterapia, 2019, 137, pp.104274. ⟨10.1016/j.fitote.2019.104274⟩

International audience; We have previously demonstrated that out of the butyrolactones series synthesized based on the natural lichen metabolite lichesterinic acid, compound (B-13) was the most effective against oral bacteria. However, its antibacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a415cf5c7b827ee95bbca802d440437c
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02280840/document

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Synthesis of peptidomimetics and chemo-biological tools for CD95/PLCγ1 interaction analysis

Autor: Nicolas Levoin, Patrick Legembre, Amanda Poissonnier, Pierre van de Weghe, Ha Thanh Nguyen, Daniel Best, Mickael Jean, Pierre Vacher, Jean-Philippe Guégan, Florence Jouan

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (16), pp.2094-2099. ⟨10.1016/j.bmcl.2019.07.006⟩

The death receptor CD95 (also known as Fas) induces apoptosis through protein/protein association and the formation of the death-inducing signaling complex. On the other hand, in certain biological conditions, this receptor recruits different protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f808a922d1329477abc13c81e64d3f74
https://pubmed.ncbi.nlm.nih.gov/31301931

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Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation

Autor: Pierre van de Weghe, Daniel Best, Mickael Jean

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2016, 81 (17), pp.7760--7770. ⟨10.1021/acs.joc.6b01426⟩
Journal of Organic Chemistry, 2016, 81 (17), pp.7760--7770. ⟨10.1021/acs.joc.6b01426⟩

International audience; One-pot formation of arylacetic acid esters, thioesters, and amides via Rh(II)-catalyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described. The methodology was used to efficiently synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d9bc2b59f63ca7028bac3a2acacb9e
https://doi.org/10.1021/acs.joc.6b01426

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Disrupting the CD95-PLC gamma 1 interaction prevents Th17-driven inflammation

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2018, 14 (12), pp.1079-+. ⟨10.1038/s41589-018-0162-9⟩
Nature Chemical Biology, 2018, 14 (12), pp.1079-+. ⟨10.1038/s41589-018-0162-9⟩

International audience; CD95L is a transmembrane ligand (m-CD95L) that is cleaved by metalloproteases to release a soluble ligand (s-CD95L). Unlike m-CD95L, interaction between s-CD95L and CD95 fails to recruit caspase-8 and FADD to trigger apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2a326251f972d1a41a88857f53e694
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01976911

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