Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Pierre, Verhaeghe"'
Autor:
Omar Khoumeri, Sébastien Hutter, Nicolas Primas, Caroline Castera-Ducros, Sandra Carvalho, Susan Wyllie, Mohamed Lotfi Efrit, Dimitri Fayolle, Marc Since, Patrice Vanelle, Pierre Verhaeghe, Nadine Azas, Hussein El-Kashef
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 878 (2024)
A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2–5 steps and their structure was proved by elemental and spectral analyses. The compounds obtained were evaluated in vitro against the promastigote stag
Externí odkaz:
https://doaj.org/article/19bbdde0254342f6abec98d71ef49a9d
Autor:
Henriette Bosson-Vanga, Nicolas Primas, Jean-François Franetich, Catherine Lavazec, Lina Gomez, Kutub Ashraf, Maurel Tefit, Valérie Soulard, Nathalie Dereuddre-Bosquet, Roger Le Grand, Mélanie Donnette, Romain Mustière, Nadia Amanzougaghene, Shahin Tajeri, Peggy Suzanne, Aurélie Malzert-Fréon, Sylvain Rault, Patrice Vanelle, Sébastien Hutter, Anita Cohen, Georges Snounou, Pierre Roques, Nadine Azas, Prisca Lagardère, Vincent Lisowski, Nicolas Masurier, Michel Nguyen, Lucie Paloque, Françoise Benoit-Vical, Pierre Verhaeghe, Dominique Mazier
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. For decades, the research for novel antimalarials focused on the high-throughput screening of molecules that only targeted
Externí odkaz:
https://doaj.org/article/b8042b3d70524640b19a2ebd49c5a820
Autor:
Romain Paoli-Lombardo, Nicolas Primas, Sandra Bourgeade-Delmas, Sébastien Hutter, Alix Sournia-Saquet, Clotilde Boudot, Emilie Brenot, Caroline Castera-Ducros, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Bertrand Courtioux, Alexis Valentin, Pierre Verhaeghe, Nadine Azas, Pascal Rathelot, Patrice Vanelle
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 998 (2022)
An antileishmanial structure–activity relationship (SAR) study focused on positions 2 and 8 of the imidazo[1,2-a]pyridine ring was conducted through the synthesis of 22 new derivatives. After being screened on the promatigote and axenic amastigote
Externí odkaz:
https://doaj.org/article/83013cdfb1b946f190f6b3a926203f86
Autor:
Prisca Lagardère, Romain Mustière, Nadia Amanzougaghene, Sébastien Hutter, Jean-François Franetich, Nadine Azas, Patrice Vanelle, Pierre Verhaeghe, Nicolas Primas, Dominique Mazier, Nicolas Masurier, Vincent Lisowski
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 820 (2022)
Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Based o
Externí odkaz:
https://doaj.org/article/dd8dfb90be544685a247478be7fb2753
Autor:
Dyhia Amrane, Christophe-Sébastien Arnold, Sébastien Hutter, Julen Sanz-Serrano, Miguel Collia, Amaya Azqueta, Lucie Paloque, Anita Cohen, Nadia Amanzougaghene, Shahin Tajeri, Jean-François Franetich, Dominique Mazier, Françoise Benoit-Vical, Pierre Verhaeghe, Nadine Azas, Patrice Vanelle, Cyrille Botté, Nicolas Primas
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 724 (2021)
The malaria parasite harbors a relict plastid called the apicoplast. Although not photosynthetic, the apicoplast retains unusual, non-mammalian metabolic pathways that are essential to the parasite, opening up a new perspective for the development of
Externí odkaz:
https://doaj.org/article/5dd08eb5d7524519bd2a427e208e3020
Autor:
Pedro Salas-Ambrosio, Antoine Tronnet, Mostafa Badreldin, Sifan Ji, Sebastien Lecommandoux, Simon Harrisson, Pierre Verhaeghe, Colin Bonduelle
Publikováno v:
Polymer Chemistry
Polymer Chemistry, 2022, 13, pp.6149-6161. ⟨10.1039/D2PY00985D⟩
Polymer Chemistry, 2022, 13, pp.6149-6161. ⟨10.1039/D2PY00985D⟩
International audience; Polypeptoids are an emerging class of biomimetic polymers prepared by ring-opening polymerization (ROP) of N-alkylated-N-carboxyanhydride (NNCA) monomers. The N-alkylation provides a unique structural isomerism with peptides b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da0fa9d437ed8543600201c4f6dc857
https://doi.org/10.1039/d2py00985d
https://doi.org/10.1039/d2py00985d
Autor:
Pedro Salas-Ambrosio, Antoine Tronnet, Mostafa Badreldin, Luzangel Reyes, Marc Since, Sandra Bourgeade-Delmas, Bruno Dupuy, Pierre Verhaeghe, Colin Bonduelle
Publikováno v:
Polymer Chemistry
Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩
Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩
International audience; We developed new macromolecular engineering approaches enabling the preparation of star-like polypeptoids by ring-opening polymerization. Parallely to the evaluation of their cytotoxicity of the HepG2 human cell line, their sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318ea43d34e094ec22ad35e3de1489e
https://doi.org/10.1039/d1py01529j
https://doi.org/10.1039/d1py01529j
Autor:
Dyhia Amrane, Armand Gellis, Sébastien Hutter, Marion Prieri, Pierre Verhaeghe, Nadine Azas, Patrice Vanelle, Nicolas Primas
Publikováno v:
Molecules, Vol 25, Iss 17, p 3929 (2020)
From three previously identified antiplasmodial hit compounds (A–C) and inactive series (D), all based on a 2-trichloromethylquinazoline scaffold, we conducted a structure-activity relationship (SAR) study at position four of the quinazoline ring b
Externí odkaz:
https://doaj.org/article/25ad1ed1698e4a08be8d62176353a8ff
Autor:
Romain Mustière, Prisca Lagardère, Sébastien Hutter, Viviana Dell’Orco, Nadia Amanzougaghene, Shahin Tajeri, Jean-François Franetich, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Nicolas Masurier, Vincent Lisowski, Pierre Verhaeghe, Dominique Mazier, Nadine Azas, Patrice Vanelle, Nicolas Primas
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩
European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩
International audience; Gamhepathiopine (also known as M1), is a multi-stage acting antiplasmodial 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hydrochloride that was first described in 2015. The development of this compound is limited by poor m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bfd963e0e1116d6ce6680442b337fa
https://hal.science/hal-03737417
https://hal.science/hal-03737417
Autor:
Prisca, Lagardère, Romain, Mustière, Nadia, Amanzougaghene, Sébastien, Hutter, Jean-François, Franetich, Nadine, Azas, Patrice, Vanelle, Pierre, Verhaeghe, Nicolas, Primas, Dominique, Mazier, Nicolas, Masurier, Vincent, Lisowski
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(7)
Malaria remains one of the major health problems worldwide. The increasing resistance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ac7c1dd8d64cfc78eb65da624833e17
https://pubmed.ncbi.nlm.nih.gov/35890119
https://pubmed.ncbi.nlm.nih.gov/35890119