Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments

Autor: Anett Jandke, Daisy Melandri, Leticia Monin, Dmitry S. Ushakov, Adam G. Laing, Pierre Vantourout, Philip East, Takeshi Nitta, Tomoya Narita, Hiroshi Takayanagi, Regina Feederle, Adrian Hayday

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Butyrophilin-like genes are emerging as central to tissue associated γδ T cell compartments. Here, the authors show that the butyropilin-like gene-products exert their effects as combinatorially diverse heteromers that differentially affect the sel

Externí odkaz: https://doaj.org/article/c213401a85c342bf9b8247f63d992ad0

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

Autor: Magdalene Joseph, Yin Wu, Richard Dannebaum, Florian Rubelt, Iva Zlatareva, Anna Lorenc, Zhipei Gracie Du, Daniel Davies, Fernanda Kyle-Cezar, Abhishek Das, Sarah Gee, Jeffrey Seow, Carl Graham, Dilduz Telman, Clara Bermejo, Hai Lin, Hosseinali Asgharian, Adam G. Laing, Irene del Molino del Barrio, Leticia Monin, Miguel Muñoz-Ruiz, Duncan R. McKenzie, Thomas S. Hayday, Isaac Francos-Quijorna, Shraddha Kamdar, Richard Davis, Vasiliki Sofra, Florencia Cano, Efstathios Theodoridis, Lauren Martinez, Blair Merrick, Karen Bisnauthsing, Kate Brooks, Jonathan Edgeworth, John Cason, Christine Mant, Katie J. Doores, Pierre Vantourout, Khai Luong, Jan Berka, Adrian C. Hayday

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(34)

Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomic DNA-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d30cd379a7c09962953e558243f5a1
https://pubmed.ncbi.nlm.nih.gov/35943978

The Innate Biologies of Adaptive Antigen Receptors

Autor: Adrian Hayday, Pierre Vantourout

Publikováno v: Annual Review of Immunology. 38:487-510

Nonclonal innate immune responses mediated by germ line–encoded receptors, such as Toll-like receptors or natural killer receptors, are commonly contrasted with diverse, clonotypic adaptive responses of lymphocyte antigen receptors generated by som

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fec7232f11da0fc34ab27a9218548d
https://doi.org/10.1146/annurev-immunol-102819-023144

A dynamic COVID-19 immune signature includes associations with poor prognosis

Autor: Aislinn Jennings, Isaac Francos-Quijorna, Manu Shankar-Hari, Adrian Hayday, Duncan R. McKenzie, John Cason, Thomas Hayday, Shraddha Kamdar, Yin Wu, Richard Davis, Matthew Fish, Kate Brooks, Blair Merrick, Katie J. Doores, Eva Bugallo-Blanco, Adam Laing, Kai Kisand, Jeremy Mason, Iva Zlatareva, Kola Babalola, Magdalene Joseph, Francesca Di Rosa, Jeffrey Seow, Philippe Moingeon, Anna Lorenc, Pärt Peterson, Daniel Davies, Mohammad A. A. Ibrahim, Efstathios Theodoridis, Federico Lopez Gomez, Liis Haljasmägi, Pierre Vantourout, Vasiliki Sofra, Abhishek Das, Maria Greco, Christine Mant, Sarah Gee, Julie Nuo En Chan, Carl Graham, Leticia Monin, Loubna Chadli, Irene del Molino del Barrio, Miguel Muñoz-Ruiz, Florencia Cano, Karen Bisnauthsing, Lauren Martinez, Sultan Abdul-Jawad, Sarah Ryan, Jonathan D. Edgeworth, Joshua D. Freedman

Publikováno v: Nature medicine
26 (2020): 1623–1635. doi:10.1038/s41591-020-1038-6
info:cnr-pdr/source/autori:Laing, Adam G.; Lorenc, Anna; del Molino del Barrio, Irene; Das, Abhishek; Fish, Matthew; Monin, Leticia; Muñoz-Ruiz, Miguel; McKenzie, Duncan R.; Hayday, Thomas S.; Francos-Quijorna, Isaac; Kamdar, Shraddha; Joseph, Magdalene; Davies, Daniel; Davis, Richard; Jennings, Aislinn; Zlatareva, Iva; Vantourout, Pierre; Wu, Yin; Sofra, Vasiliki; Cano, Florencia; Greco, Maria; Theodoridis, Efstathios; Freedman, Joshua; Gee, Sarah; Chan, Julie Nuo En; Ryan, Sarah; Bugallo-Blanco, Eva; Peterson, Pärt; Kisand, Kai; Haljasmägi, Liis; Chadli, Loubna; Moingeon, Philippe; Martinez, Lauren; Merrick, Blair; Bisnauthsing, Karen; Brooks, Kate; Ibrahim, Mohammad A.A.; Mason, Jeremy; Lopez Gomez, Federico; Babalola, Kola; Abdul-Jawad, Sultan; Cason, John; Mant, Christine; Seow, Jeffrey; Graham, Carl; Doores, Katie J.; Di Rosa, Francesca; Edgeworth, Jonathan; Shankar-Hari, Manu; Hayday, Adrian C./titolo:A dynamic COVID-19 immune signature includes associations with poor prognosis/doi:10.1038%2Fs41591-020-1038-6/rivista:Nature medicine (Print)/anno:2020/pagina_da:1623/pagina_a:1635/intervallo_pagine:1623–1635/volume:26
Nature Medicine

Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f5fa781e4a5acfc0a8216290f81914
http://www.cnr.it/prodotto/i/439414

Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology

Autor: Adam Laing, Michael H. Malim, Iva Zlatareva, Adrian Hayday, Ambrosius P. Snijders, Pierre Vantourout, Martin Woodward, Luis Apolonia, Andrew W. Jones

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Vantourout, P, Laing, A, Woodward, M J, Zlatareva, I, Apolonia, L, Jones, A W, Snijders, A P, Malim, M H & Hayday, A C 2018, ' Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 5, pp. 1039-1044 . https://doi.org/10.1073/pnas.1701237115

Significance Although gamma delta (γδ) T cells compose an evolutionarily conserved third lineage of diversified lymphocytes, alongside αβ T cells and B cells, they can seem overtly different across species and tissues. Thus, human blood γδ cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677980dd6f31d5a331bc59a631f06c8f
https://doi.org/10.1073/pnas.1701237115