Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Pierre, Legrand"'
Autor:
Fouad Ouasti, Maxime Audin, Karine Fréon, Jean-Pierre Quivy, Mehdi Tachekort, Elizabeth Cesard, Aurélien Thureau, Virginie Ropars, Paloma Fernández Varela, Gwenaelle Moal, Ibrahim Soumana-Amadou, Aleksandra Uryga, Pierre Legrand, Jessica Andreani, Raphaël Guerois, Geneviève Almouzni, Sarah Lambert, Francoise Ochsenbein
Publikováno v:
eLife, Vol 12 (2024)
Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and functions are st
Externí odkaz:
https://doaj.org/article/e4eaadc73ce04cfaa4c47752fee0fda9
Autor:
Clément Madru, Markel Martínez-Carranza, Sébastien Laurent, Alessandra C. Alberti, Maelenn Chevreuil, Bertrand Raynal, Ahmed Haouz, Rémy A. Le Meur, Marc Delarue, Ghislaine Henneke, Didier Flament, Mart Krupovic, Pierre Legrand, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Replication Protein A (RPA) is a heterotrimeric single stranded DNA-binding protein with essential roles in DNA replication, recombination and repair. Little is known about the structure of RPA in Archaea, the third domain of life. By using
Externí odkaz:
https://doaj.org/article/8ae48732a3044f69b9e87147a45794c9
Autor:
Ornella Bimai, Pierre Legrand, Jean-Luc Ravanat, Nadia Touati, Jingjing Zhou, Nisha He, Marine Lénon, Frédéric Barras, Marc Fontecave, Béatrice Golinelli-Pimpaneau
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Thiolation of uridine 34 in the anticodon loop of several tRNAs is conserved in the three domains of life and guarantees fidelity of protein translation. U34-tRNA thiolation is catalyzed by a complex of two proteins in the eukaryotic cytosol
Externí odkaz:
https://doaj.org/article/602a88f39c8c47ce862dac8db03055fc
Autor:
Pierre Legrand
Publikováno v:
Revista de Investigações Constitucionais, Vol 10, Iss 1, Pp e231-e231 (2023)
This article challenges four basic and intertwining assumptions informing orthodox comparative law: that a comparatist can exactly represent foreign law; that he can write about foreign law objectively; that he can state the truth regarding foreign l
Externí odkaz:
https://doaj.org/article/6e809145dd00442396447a8c4b22ccb5
Autor:
Pierre Legrand, Yves L. Janin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 935-943 (2022)
In 1949, Reuben G. Jones disclosed an original synthesis of 2-hydroxypyrazines involving a double condensation between 1,2-dicarbonyls and α-aminoamides upon treatment with sodium hydroxide at low temperature. This discovery turned out to be of impo
Externí odkaz:
https://doaj.org/article/2d3b5a6edb3540eb8540f5d5975bd11a
Autor:
Prashant P. Damke, Louisa Celma, Sumedha M. Kondekar, Anne Marie Di Guilmi, Stéphanie Marsin, Jordane Dépagne, Xavier Veaute, Pierre Legrand, Hélène Walbott, Julien Vercruyssen, Raphaël Guérois, Sophie Quevillon-Cheruel, J. Pablo Radicella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The ComFC protein is essential for natural transformation, a process that plays a major role in the spread of antibiotic resistance genes. Here the authors show that ComFC is a membrane-associated protein that participates in the transport of DNA thr
Externí odkaz:
https://doaj.org/article/4ad2f5c9255c489b8729c24291247cdd
Autor:
Carole Fruchart Gaillard, Ali Ben Djoudi Ouadda, Lidia Ciccone, Emmanuelle Girard, Sepideh Mikaeeli, Alexandra Evagelidis, Maïlys Le Dévéhat, Delia Susan-Resiga, Evelyne Cassar Lajeunesse, Hervé Nozach, Oscar Henrique Pereira Ramos, Aurélien Thureau, Pierre Legrand, Annik Prat, Vincent Dive, Nabil G. Seidah
Publikováno v:
Molecular Metabolism, Vol 67, Iss , Pp 101662- (2023)
Objective: The liver-derived circulating PCSK9 enhances the degradation of the LDL receptor (LDLR) in endosomes/lysosomes. PCSK9 inhibition or silencing is presently used in clinics worldwide to reduce LDL-cholesterol, resulting in lower incidence of
Externí odkaz:
https://doaj.org/article/25b8b2644d1147d09b7ec706733b10c7
Autor:
Pierre Legrand
Publikováno v:
Revista de Investigações Constitucionais, Vol 8, Iss 3, Pp 601-654 (2021)
While much legal research involves foreign law and much of foreign law exists in a foreign language, the issue of translation has attracted limited theoretical attention only. In particular, few lawyers are aware of the work issuing from fields like
Externí odkaz:
https://doaj.org/article/f088d2ee71d543e3bfcef015c59660e4
Autor:
Rania Ghouil, Simona Miron, Lieke Koornneef, Jasper Veerman, Maarten W. Paul, Marie-Hélène Le Du, Esther Sleddens-Linkels, Sari E. van Rossum-Fikkert, Yvette van Loon, Natalia Felipe-Medina, Alberto M. Pendas, Alex Maas, Jeroen Essers, Pierre Legrand, Willy M. Baarends, Roland Kanaar, Sophie Zinn-Justin, Alex N. Zelensky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
BRCA2 and its interactor HSF2BP are required for meiotic recombination. Here, the authors define the interaction structurally, revealing that a repeat in BRCA2 binds two HSF2BP units, increasing the affinity. This region is, however, not essential fo
Externí odkaz:
https://doaj.org/article/0b53e0fe0b894a1fac23825f31a88406
Autor:
Justyna Ciolek, Claude Zoukimian, Justine Dhot, Mélanie Burban, Mathilde Triquigneaux, Benjamin Lauzier, Christelle Guimbert, Didier Boturyn, Marine Ferron, Lidia Ciccone, Livia Tepshi, Enrico Stura, Pierre Legrand, Philippe Robin, Gilles Mourier, Béatrice Schaack, Imen Fellah, Guillaume Blanchet, Chantal Gauthier-Erfanian, Rémy Beroud, Denis Servent, Michel De Waard, Nicolas Gilles
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 113094- (2022)
All five muscarinic receptors have important physiological roles. The endothelial M2 and M3 subtypes regulate arterial tone through direct coupling to Gq or Gi/o proteins. Yet, we lack selective pharmacological drugs to assess the respective contribu
Externí odkaz:
https://doaj.org/article/81fb19f4b1464cb2be0363e9765a0645