Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Pierre, Lavigne"'
Autor:
Emmanuelle Wilhelm, Mikaël Poirier, Morgane Da Rocha, Mikaël Bédard, Patrick P McDonald, Pierre Lavigne, Christie L Hunter, Brendan Bell
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1011821 (2024)
The human immunodeficiency virus (HIV) integrates into the host genome forming latent cellular reservoirs that are an obstacle for cure or remission strategies. Viral transcription is the first step in the control of latency and depends upon the hija
Externí odkaz:
https://doaj.org/article/acce5adfc29f4b478bfd2184a855265c
Autor:
Sára Ferková, Ulrike Froehlich, Marie-Édith Nepveu-Traversy, Alexandre Murza, Taha Azad, Michel Grandbois, Philippe Sarret, Pierre Lavigne, Pierre-Luc Boudreault
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 166 (2023)
Medicinal chemistry is constantly searching for new approaches to develop more effective and targeted therapeutic molecules. The design of peptidomimetics is a promising emerging strategy that is aimed at developing peptides that mimic or modulate th
Externí odkaz:
https://doaj.org/article/d49131778d794d5eae365897b6972617
Autor:
Marie-Line Dubois, Anna Meller, Sondos Samandi, Mylène Brunelle, Julie Frion, Marie A. Brunet, Amanda Toupin, Maxime C. Beaudoin, Jean-François Jacques, Dominique Lévesque, Michelle S. Scott, Pierre Lavigne, Xavier Roucou, François-Michel Boisvert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Ubiquitin pseudogenes are present in many organisms but whether they encode functional proteins has remained unclear. Here, the authors show that human UBB pseudogene 4 produces ubiquitin variants with amino acid compositions and cellular functions t
Externí odkaz:
https://doaj.org/article/8ce974c41a46437d9f1dfb98b66ade74
Autor:
Loïka Maltais, Martin Montagne, Mikaël Bédard, Cynthia Tremblay, Laura Soucek, Pierre Lavigne
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174413 (2017)
It is classically recognized that the physiological and oncogenic functions of Myc proteins depend on specific DNA binding enabled by the dimerization of its C-terminal basic-region-Helix-Loop-Helix-Leucine Zipper (b-HLH-LZ) domain with that of Max.
Externí odkaz:
https://doaj.org/article/47ee33916a1247eab6532ff7bd65aafa
Autor:
Danny Létourneau, Aurélien Lorin, Andrée Lefebvre, Vincent Frappier, Francis Gaudreault, Rafael Najmanovich, Pierre Lavigne, Jean-Guy LeHoux
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2677-2689 (2012)
Steroidogenic acute regulatory-related lipid transfer (START) domain proteins are involved in the nonvesicular intracellular transport of lipids and sterols. The STARD1 (STARD1 and STARD3) and STARD4 subfamilies (STARD4–6) have an internal cavity l
Externí odkaz:
https://doaj.org/article/3e20e8ba00a143d4839f5733c94465a5
Autor:
Richard Leduc, Alexandre Connolly, Pierre Lavigne, Jean-Patrice Baillargeon, Brian J. Holleran, Elie Simard
Publikováno v:
Biochemical Pharmacology. 168:330-338
The signaling mechanisms of the angiotensin II type 2 receptor (AT2R), a heptahelical receptor, have not yet been clearly and completely defined. In the present contribution, we set out to identify the molecular determinants involved in AT2R activati
Autor:
Nicholas Bruce, Robert Messing, Michael A. Smith, Timothy Robishaw, Jean-Pierre Lavigne, Stephen Harrison, Benoit Robert, Aneet Lakhani, Charl Baard, David Del Rizzo
Publikováno v:
2021 XXXIVth General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS).
In this paper we present the system design for the radio frequency interference monitor at the Dominion Radio Astrophysical Observatory (DRAO). Although the design is focused on requirements generated from the needs of local telescopes and personnel,
Autor:
Ronald Gold, Luis Barreto, Santiago Ferro, John Thippawong, Roland Guasparini, William Meekison, Margaret Russell, Elaine Mills, Dana Harrison, Pierre Lavigne
Publikováno v:
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 18, Iss 4, Pp 241-248 (2007)
OBJECTIVE: The safety, immunogenicity and lot consistency of a fully liquid, five-component acellular pertussis combination vaccine, comprised of diphteria, tetanus and acellular pertussis, inactivated polio vaccine, Haemophilus influenzae type b (DT
Externí odkaz:
https://doaj.org/article/864ff81200284edd818ce413e4d9c984
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2318
The b-HLH-LZ domain of c-Myc is a key target for the development of cancer therapies by blunting its binding to DNA with cell penetrant b-HLH-LZs and/or by stabilizing it into a state that cannot recognize Max to activate and amplify transcription of
Autor:
Olivier Boisvert, Danny Létourneau, Patrick Delattre, Cynthia Tremblay, Émilie Jolibois, Martin Montagne, Pierre Lavigne
Publikováno v:
Structure. 30:623-636.e5
Miz-1 (ZBTB17) is a poly-zinc finger BTB/POZ transcription factor with 12 consecutive C2H2 zinc fingers (ZFs) that binds transcriptional start sites (TSSs) to regulate the expression of genes involved in cell development and proliferation. As of now,