The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

Autor: Léa J. Becker, Clémentine Fillinger, Robin Waegaert, Sarah H. Journée, Pierre Hener, Beyza Ayazgok, Muris Humo, Meltem Karatas, Maxime Thouaye, Mithil Gaikwad, Laetitia Degiorgis, Marie des Neiges Santin, Mary Mondino, Michel Barrot, El Chérif Ibrahim, Gustavo Turecki, Raoul Belzeaux, Pierre Veinante, Laura A. Harsan, Sylvain Hugel, Pierre-Eric Lutz, Ipek Yalcin

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Abstract While depression and chronic pain are frequently comorbid, underlying neuronal circuits and their psychopathological relevance remain poorly defined. Here we show in mice that hyperactivity of the neuronal pathway linking the basolateral amy

Externí odkaz: https://doaj.org/article/79edb28876214399bf2915cb6fdcd98c

Corrigendum: IL-3 produced by T cells is crucial for basophil extravasation in hapten- induced allergic contact dermatitis

Autor: Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam, Pierre Meyer, Eric Flatter, Marie-Christine Birling, Jagadeesh Bayry, Mei Li

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Externí odkaz: https://doaj.org/article/50cb684bc2904361bd3a69236534edeb

IL-3 produced by T cells is crucial for basophil extravasation in hapten-induced allergic contact dermatitis

Autor: Carole El Hachem, Pierre Marschall, Pierre Hener, Anupama Karnam, Srinivasa Reddy Bonam, Pierre Meyer, Eric Flatter, Marie-Christine Birling, Jagadeesh Bayry, Mei Li

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Basophils have been recognized as a characterized cellular player for Th2 immune responses implicated in allergic diseases, but the mechanisms responsible for basophil recruitment to allergic skin remain not well understood. Using a hapten fluorescei

Externí odkaz: https://doaj.org/article/4870538883134a0fa7ee3562d4798a3e

Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment

Autor: Wenjin Yao, Beatriz German, Dounia Chraa, Antoine Braud, Cecile Hugel, Pierre Meyer, Guillaume Davidson, Patrick Laurette, Gabrielle Mengus, Eric Flatter, Pierre Marschall, Justine Segaud, Marine Guivarch, Pierre Hener, Marie-Christine Birling, Dan Lipsker, Irwin Davidson, Mei Li

Publikováno v: JCI Insight
JCI Insight, 2022, ⟨10.1172/jci.insight.161438⟩

International audience; Malignant melanoma is a major public health issue displaying frequent resistance to targeted therapy and immunotherapy. A major challenge lies in better understanding how melanoma cells evade immune elimination and how tumor g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da84956e9a6a7b84e228f124c0b9edaf
https://hal.science/hal-03808723

Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice

Autor: Franck Mouthon, Nolwenn Couqueberg, Virginie Andry, Perrine Inquimbert, Quentin Leboulleux, Marine Droguerre, Baptiste Letellier, Pierre Hener, Michel Barrot, Ipek Yalcin, Mathieu Charvériat, Mélanie Kremer, Yannick Goumon, Elisabeth Waltisperger, Léa J. Becker

Publikováno v: PAIN
PAIN, Elsevier, 2021, Publish Ahead of Print, ⟨10.1097/j.pain.0000000000002276⟩
PAIN, 2021, 162 (12), pp.2841-2853. ⟨10.1097/j.pain.0000000000002276⟩
Pain

Supplemental Digital Content is Available in the Text. Mefloquine/amitriptyline THN101 combination reduces cuff-induced neuropathic hypersensitivity by recruiting noradrenergic descending pathways and α2 adrenoceptors and by blocking connexin in mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24305fc7e1fa53636f828d27fe9f0761
https://hal.archives-ouvertes.fr/hal-03407798