Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Pierre, Guermonprez"'
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Autor:
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the potential of DC-based therapies in
Externí odkaz:
https://doaj.org/article/f7c6a9ff87e544acbdd02715c577e12b
Autor:
Nicoletta Caronni, Giulia Maria Piperno, Francesca Simoncello, Oriana Romano, Simone Vodret, Yuichi Yanagihashi, Regine Dress, Charles-Antoine Dutertre, Mattia Bugatti, Pierre Bourdeley, Annalisa Del Prete, Tiziana Schioppa, Emilia Maria Cristina Mazza, Licio Collavin, Serena Zacchigna, Renato Ostuni, Pierre Guermonprez, William Vermi, Florent Ginhoux, Silvio Bicciato, Shigekatzu Nagata, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated c
Externí odkaz:
https://doaj.org/article/ed313efe49174e4e8c4bd8e169965081
Autor:
Irini Evnouchidou, Pascal Chappert, Samira Benadda, Andres Zucchetti, Mirjana Weimershaus, Marcelle Bens, Vivien Caillens, Despoina Koumantou, Sophie Lotersztajn, Peter van Endert, Jean Davoust, Pierre Guermonprez, Claire Hivroz, David A. Gross, Loredana Saveanu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
T cell receptors (TCR) are internalized when activated by their ligands. Here the authors show that the internalized TCRs are localized to endosomes expressing IRAP and Syntaxin 6 to maintain intracellular signalling capacity, whose importance is sho
Externí odkaz:
https://doaj.org/article/64b251bfea0c4668a8923bf82ed550e8
Autor:
Giorgio Anselmi, Kristine Vaivode, Charles-Antoine Dutertre, Pierre Bourdely, Yoann Missolo-Koussou, Evan Newell, Oliver Hickman, Kristie Wood, Alka Saxena, Julie Helft, Florent Ginhoux, Pierre Guermonprez
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specific
Externí odkaz:
https://doaj.org/article/063014aa8c3746a095f182dc864bceda
Autor:
Alice Pievani, Roberto Savoldelli, Juliane Poelchen, Elisa Mattioli, Giorgio Anselmi, Alice Girardot, Jochen Utikal, Pierre Bourdely, Marta Serafini, Pierre Guermonprez
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is es
Externí odkaz:
https://doaj.org/article/0f513972e2044522bea853a714f9d80a
Autor:
Florent Ginhoux, Alexander Mildner, Emmanuel L. Gautier, Andreas Schlitzer, Claudia Jakubzick, Chen Varol, Calum Bain, Pierre Guermonprez
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/9b85d3eb5788448985bed55198e3907c
Autor:
Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Diana Dudziak, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cell
Externí odkaz:
https://doaj.org/article/dbd16a54534b4219875414603574c2bc
Autor:
Claire B. Péan, Mark Schiebler, Sharon W. S. Tan, Jessica A. Sharrock, Katrin Kierdorf, Karen P. Brown, M. Charlotte Maserumule, Shinelle Menezes, Martina Pilátová, Kévin Bronda, Pierre Guermonprez, Brian M. Stramer, R. Andres Floto, Marc S. Dionne
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Cytokines and their associated pathways can affect survival ofMycobacterium tuberculosis in macrophages, representing potential targets for host-directed therapies. Here, Péan et al. show that cytokine-STAT signalling promotes mycobacterial survival
Externí odkaz:
https://doaj.org/article/4bd8daccf57b461585b4d2bad37cf1c1
Autor:
Lucia Lopez-Rodriguez, Pierre Bourdely, Federica La Terza, Giuseppe Rospo, Luciano Morosi, Roberto Amadio, Giulia Maria Piperno, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
The efficacy of immune checkpoint blockade (ICB) in NSCLC depends on the tumor mutational burden (TMB). However, a fraction of patients with high TMB and predicted immunogenic neoantigens (neoAgs) do not respond. Here we show that in a model of highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b69461aa9cfa096a596e894578f8ec5
https://doi.org/10.21203/rs.3.rs-2752957/v1
https://doi.org/10.21203/rs.3.rs-2752957/v1
Autor:
Pierre Bourdely, Roberto Savoldelli, Mathias Vetillard, Giorgio Anselmi, Julie Helft, Pierre Guermonprez
Publikováno v:
Methods in Molecular Biology ISBN: 9781071629376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67f343761c715291fce844541843b5da
https://doi.org/10.1007/978-1-0716-2938-3_9
https://doi.org/10.1007/978-1-0716-2938-3_9