Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Pierre, Genevaux"'
Autor:
Xibing Xu, Roland Barriot, Bertille Voisin, Tom J. Arrowsmith, Ben Usher, Claude Gutierrez, Xue Han, Carine Pagès, Peter Redder, Tim R. Blower, Olivier Neyrolles, Pierre Genevaux
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Toxins of toxin-antitoxin systems use diverse mechanisms to inhibit bacterial growth. In this study, we characterize the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis in humans. W
Externí odkaz:
https://doaj.org/article/a6a95752a8d84444819329042914e71e
Autor:
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance. The Mycobacterium tuberculosis NTase toxin family, MenT, modifies tRNAs to block tra
Externí odkaz:
https://doaj.org/article/0b8cfa70586a40899ff0c0d5f6b0b175
Autor:
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R. Blower, Pierre Genevaux
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M. tuberculosis genome encod
Externí odkaz:
https://doaj.org/article/192b7c0f9cc2492486b0eb24b655df5a
Autor:
Moise Mansour, Emmanuel Giudice, Xibing Xu, Hatice Akarsu, Patricia Bordes, Valérie Guillet, Donna-Joe Bigot, Nawel Slama, Gaetano D’urso, Sophie Chat, Peter Redder, Laurent Falquet, Lionel Mourey, Reynald Gillet, Pierre Genevaux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Toxin-antitoxin systems are widespread in bacteria. Here the authors present structures of M. tuberculosis HigBTAC alone and bound to the ribosome in the presence of native cspA mRNA, shedding light on its mechanism of translation inhibition.
Externí odkaz:
https://doaj.org/article/1ad0741fe184439087433a275dfe666e
Autor:
Lisa Zuily, Nora Lahrach, Rosi Fassler, Olivier Genest, Peter Faller, Olivier Sénèque, Yann Denis, Marie-Pierre Castanié-Cornet, Pierre Genevaux, Ursula Jakob, Dana Reichmann, Marie-Thérèse Giudici-Orticoni, Marianne Ilbert
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Copper is well known for its antimicrobial and antiviral properties. Under aerobic conditions, copper toxicity relies in part on the production of reactive oxygen species (ROS), especially in the periplasmic compartment. However, copper is s
Externí odkaz:
https://doaj.org/article/d2b88acbd8ca489194f154fe226ef8b8
Autor:
Valérie Guillet, Patricia Bordes, Cécile Bon, Julien Marcoux, Virginie Gervais, Ambre Julie Sala, Suzana Dos Reis, Nawel Slama, Israel Mares-Mejía, Anne-Marie Cirinesi, Laurent Maveyraud, Pierre Genevaux, Lionel Mourey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of t
Externí odkaz:
https://doaj.org/article/a3545627c95b4aebbc2831156701c6af
Autor:
Patricia Bordes, Pierre Genevaux
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their cellular functions and activation m
Externí odkaz:
https://doaj.org/article/9dcf5cc8991141728bf2d3575f13b1b4
Autor:
Bruno Fauvet, Andrija Finka, Marie-Pierre Castanié-Cornet, Anne-Marie Cirinesi, Pierre Genevaux, Manfredo Quadroni, Pierre Goloubinoff
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
In eukaryotes, the 90-kDa heat shock proteins (Hsp90s) are profusely studied chaperones that, together with 70-kDa heat shock proteins (Hsp70s), control protein homeostasis. In bacteria, however, the function of Hsp90 (HtpG) and its collaboration wit
Externí odkaz:
https://doaj.org/article/970197eb0bba44c6bea6a1507738f3d2
Publikováno v:
BioTechniques, Vol 65, Iss 3, Pp 159-162 (2018)
A direct method to study essential genes is to construct conditional knock-down mutants by replacement of their native promoter by an inducible one. In Mycobacteria, replacement of an essential gene promoter with an anhydrotetracycline inducible one
Externí odkaz:
https://doaj.org/article/3ebce568d0d041499f83b32d35e2179f
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Many bacterial proteins exhibit spatially defined localization important for function. Here the authors show that the polar localization of Shigella IpaC type III secretion substrate is mediated by its interaction with the DnaK chaperone and occlusio
Externí odkaz:
https://doaj.org/article/34f8c4d1222449c3af8aeff533690b22