Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Pierre, Gönczy"'
Autor:
Aleksandar Salim, Philipp Werther, Georgios N. Hatzopoulos, Luc Reymond, Richard Wombacher, Pierre Gönczy, Kai Johnsson
Publikováno v:
JACS Au, Vol 3, Iss 8, Pp 2247-2256 (2023)
Externí odkaz:
https://doaj.org/article/5e6a37777aa84ef59ba4b48e55b70e93
Autor:
Léo Bürgy, Martin Weigert, Georgios Hatzopoulos, Matthias Minder, Adrien Journé, Sahand Jamal Rahi, Pierre Gönczy
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background High-throughput and selective detection of organelles in immunofluorescence images is an important but demanding task in cell biology. The centriole organelle is critical for fundamental cellular processes, and its accurate detect
Externí odkaz:
https://doaj.org/article/ecbf773f95434e0bbc207250a55486d4
Autor:
Nils Kalbfuss, Pierre Gönczy
Publikováno v:
Open Biology, Vol 13, Iss 11 (2023)
Centrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our unde
Externí odkaz:
https://doaj.org/article/5622a901ee444beb818cf416b26b4f57
Autor:
Niccolò Banterle, Adrian P. Nievergelt, Svenja de Buhr, Georgios N. Hatzopoulos, Charlène Brillard, Santiago Andany, Tania Hübscher, Frieda A. Sorgenfrei, Ulrich S. Schwarz, Frauke Gräter, Georg E. Fantner, Pierre Gönczy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The centriole exhibits an evolutionarily conserved 9-fold radial symmetry that stems from a cartwheel containing vertically stacked ring polymers that harbor 9 homodimers of the protein SAS-6. Here the authors show how dual properties inherent to sur
Externí odkaz:
https://doaj.org/article/62dd094a411e49c59faaf20446460035
Autor:
Alexander Woglar, Marie Pierron, Fabian Zacharias Schneider, Keshav Jha, Coralie Busso, Pierre Gönczy
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001784 (2022)
Uncovering organizing principles of organelle assembly is a fundamental pursuit in the life sciences. Caenorhabditis elegans was key in identifying evolutionary conserved components governing assembly of the centriole organelle. However, localizing t
Externí odkaz:
https://doaj.org/article/e1c80b6142c442b2b7a16f21076d37c3
Autor:
Georgios N. Hatzopoulos, Tim Kükenshöner, Niccolò Banterle, Tatiana Favez, Isabelle Flückiger, Virginie Hamel, Santiago Andany, Georg E. Fantner, Oliver Hantschel, Pierre Gönczy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that scaffolds organelle formation. Here, the authors develop monobodies against Chlamydomonas reinhardtii SAS-6
Externí odkaz:
https://doaj.org/article/c2111ed0fd0843e78837713fbdafff46
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Correct spindle positioning is critical for cell division but the full set of proteins regulating this is unclear. Here, with a live imaging siRNA-based screen in human cells, the authors identify 16 candidates required for this process, 11 of which
Externí odkaz:
https://doaj.org/article/dc1c4c62f71940c7926647e7846ea1ab
Publikováno v:
eLife, Vol 10 (2021)
Asymmetric divisions that yield daughter cells of different sizes are frequent during early embryogenesis, but the importance of such a physical difference for successful development remains poorly understood. Here, we investigated this question usin
Externí odkaz:
https://doaj.org/article/9d3f1984f81f4a8f963f5ddaeab7827f
Autor:
Fernando R Balestra, Andrés Domínguez-Calvo, Benita Wolf, Coralie Busso, Alizée Buff, Tessa Averink, Marita Lipsanen-Nyman, Pablo Huertas, Rosa M Ríos, Pierre Gönczy
Publikováno v:
eLife, Vol 10 (2021)
TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we
Externí odkaz:
https://doaj.org/article/43c73efe37f44b62a2ac44ad88b4b1c6
Autor:
Nils Kalbfuss, Pierre Gönczy
Publikováno v:
Science Advances. 9
Centrioles are critical for fundamental cellular processes, including signaling, motility, and division. The extent to which centrioles are present after cell cycle exit in a developing organism is not known. The stereotypical lineage of Caenorhabdit