Validation of a whole slide image management system for metabolic‐associated steatohepatitis for clinical trials

Autor: Hanna Pulaski, Shraddha S Mehta, Laryssa C Manigat, Stephanie Kaufman, Hypatia Hou, ILKe Nalbantoglu, Xuchen Zhang, Emily Curl, Ross Taliano, Tae Hun Kim, Michael Torbenson, Jonathan N Glickman, Murray B Resnick, Neel Patel, Cristin E Taylor, Pierre Bedossa, Michael C Montalto, Andrew H Beck, Katy E Wack

Publikováno v: The Journal of Pathology: Clinical Research, Vol 10, Iss 5, Pp n/a-n/a (2024)

Abstract The gold standard for enrollment and endpoint assessment in metabolic dysfunction‐associated steatosis clinical trials is histologic assessment of a liver biopsy performed on glass slides. However, obtaining the evaluations from several ex

Externí odkaz: https://doaj.org/article/eb1dc91a8f284aa1a624e1e8e3395dbb

Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests

Autor: Jérôme Boursier, Marine Roux, Charlotte Costentin, Julien Chaigneau, Céline Fournier-Poizat, Aldo Trylesinski, Clémence M. Canivet, Sophie Michalak, Brigitte Le Bail, Valérie Paradis, Pierre Bedossa, Nathalie Sturm, Victor de Ledinghen, AFEF group for the study of liver fibrosis, M118 study group, Philip N. Newsome

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients wit

Externí odkaz: https://doaj.org/article/99986da61237412caf7c819f849664b4

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Autor: Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly, James Clark, Heather J. Cordell, Rebecca Darlay, Christopher P. Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M. Bossuyt, Adriaan G. Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss

Publikováno v: JHEP Reports, Vol 4, Iss 2, Pp 100409- (2022)

Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 s

Externí odkaz: https://doaj.org/article/bf7c90fd285b4e33a8d02523458d147c

Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease

Autor: Marie Boyle, Dina Tiniakos, Jorn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianessi, Salvatore Petta, Claudia P. Oliveira, Olivier Govaere, Ramy Younes, Stuart McPherson, Pierre Bedossa, Mette J Nielsen, Morten Karsdal, Diana Leeming, Stuart Kendrick, Quentin M. Anstee

Publikováno v: JHEP Reports, Vol 1, Iss 3, Pp 188-198 (2019)

Background & Aim: There is an unmet need for non-invasive biomarkers in non-alcoholic fatty liver disease (NAFLD) that can diagnose advanced disease and identify patients suitable for clinical trials. The PRO-C3 collagen neo-epitope is a putative dir

Externí odkaz: https://doaj.org/article/f958887b90bf4e228506b87bb3e16db4

Evaluation of PXL065 – deuterium-stabilized (R)-pioglitazone in patients with NASH: A phase II randomized placebo-controlled trial (DESTINY-1)

Autor: Stephen A. Harrison, Carole Thang, Sébastien Bolze, Sheila Dewitt, Sophie Hallakou-Bozec, Julie Dubourg, Pierre Bedossa, Kenneth Cusi, Vlad Ratziu, Jean-Marie Grouin, David E. Moller, Pascale Fouqueray

Publikováno v: Journal of Hepatology. 78:914-925

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c2022eb9d74d7f1233445c09013c96d
https://doi.org/10.1016/j.jhep.2023.02.004