Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Pierre, Adumeau"'
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Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET
Autor: Brian M. Zeglis, Outi Keinänen, Kimberly J. Edwards, Vikram Natwarsinhji Sisodiya, Ashwin Ragupathi, Sai Kiran Sharma, Jason S. Lewis, Omar Hamdy, Robert Tchelepi, Charles M. Rudin, John T. Poirier, Jacob Pourat, Joshua A. Korsen, Hetal Sarvaiya, Laura Saunders, Pierre Adumeau
Publikováno v: Bioconjugate Chemistry
Delta-like ligand 3 (DLL3) is a therapeutic target for the treatment of small cell lung cancer, neuroendocrine prostate cancer, and isocitrate dehydrogenase mutant glioma. In the clinic, DLL3-targeted 89Zr-immunoPET has the potential to aid in the as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883036cf5c478ef569dd470e2016a6c2
http://europepmc.org/articles/PMC8295218
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3
The Influence of Glycans-Specific Bioconjugation on the FcγRI Binding and In vivo Performance of 89Zr-DFO-Pertuzumab
Autor: Kimberly Fung, Sai Kiran Sharma, Cindy Rodriguez, Gary A. Ulaner, Pierre Adumeau, Jason S. Lewis, Brian M. Zeglis, Delphine Vivier
Publikováno v: Theranostics. 10:1746-1757
Rationale: The overwhelming majority of radioimmunoconjugates are produced via random conjugation methods predicated on attaching bifunctional chelators to the lysines of antibodies. However, this approach inevitably produces poorly defined and heter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e05292a2cea9a0b75aa7a835691386df
https://doi.org/10.7150/thno.39089
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4
Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors
Autor: Pierre Adumeau, René Raavé, Milou Boswinkel, Sandra Heskamp, Hans J. C. T. Wessels, Alain J. van Gool, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Victor Goncalves, Franck Denat
Publikováno v: Bioconjugate Chemistry, 33, 3, pp. 530-540
Bioconjugate Chemistry, 33, 530-540
Because positron emission tomography (PET) and optical imaging are very complementary, the combination of these two imaging modalities is very enticing in the oncology field. Such bimodal imaging generally relies on imaging agents bearing two differe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b25d8c7efc9cf76f5f26579228e84b
https://pubmed.ncbi.nlm.nih.gov/35230093
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5
Monodisperse silica nanoparticles doped with dipicolinic acid-based luminescent lanthanide(iii) complexes for bio-labelling
Autor: Pierre Adumeau, Arnaud Gautier, Jean-Louis Canet, Rachid Mahiou, Claude Beaudoin, Damien Boyer, Cédric Hesling, Claire Gaillard, Laurent Morel
Publikováno v: Journal of materials chemistry. B. 1(34)
The facile synthesis of functionalized luminescent nanoparticles from LnL3 lanthanide complexes is described. The luminescence properties of the lanthanide chelates and of the corresponding nanohybrids are reported and compared. For a further applica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb742868c7e44775ffa7bd51f28d42d
https://pubmed.ncbi.nlm.nih.gov/32261027
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6
Manipulating the In Vivo Behaviour of 68Ga with Tris(Hydroxypyridinone) Chelators: Pretargeting and Blood Clearance
Autor: Jason S. Lewis, Brian M. Zeglis, Samantha Y.A. Terry, Cinzia Imberti, Philip J. Blower, Julia E. Blower, Pierre Adumeau, Julia Baguña Torres, Fahad Al Salemee
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4, p 1496 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 4
Pretargeting is widely explored in immunoPET as a strategy to reduce radiation exposure of non-target organs and allow the use of short-lived radionuclides that would not otherwise be compatible with the slow pharmacokinetic profiles of antibodies. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a874fe8d931964cda3312e8962e5a08e
https://www.mdpi.com/1422-0067/21/4/1496
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7
Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging
Autor: Kirsten Raun, Pierre Adumeau, Victor Goncalves, James N. McGuire, Inga Bjørnsdottir, Mathieu Moreau, Franck Denat, Sandra Heskamp, René Raavé, Ibai E. Valverde, Magnus Gustafsson, Mette Finderup Grove, Christian Borch Jacobsen, Jesper B. Kristensen, Marie Østergaard Pedersen
Publikováno v: Nuclear Medicine and Biology, 82-83, 49-56
Nuclear Medicine and Biology, 82-83, pp. 49-56
Nuclear Medicine and Biology
Nuclear Medicine and Biology, Elsevier, 2020, 82-83, pp.49-56. ⟨10.1016/j.nucmedbio.2019.11.006⟩
Contains fulltext : 220838.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Lately, zirconium-89 has shown great promise as a radionuclide for PET applications of long circulating biomolecules. Here, the design and synthesis of protracted and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d769066221a062666772249186c1e2
http://hdl.handle.net/2066/220838
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8
Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability
Autor: Maria Davydova, Brian M. Zeglis, Pierre Adumeau
Publikováno v: Bioconjugate Chemistry. 29:1364-1372
Maleimide-bearing bifunctional chelators have been used extensively for the site-selective bioconjugation and radiolabeling of peptides and proteins. However, bioconjugates obtained using these constructs inevitably suffer from limited stability in v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a1065fb4f7ee1e9d9e99e3ccf83671
https://doi.org/10.1021/acs.bioconjchem.8b00081
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9
Site-Specifically Labeled Antibody–Drug Conjugate for Simultaneous Therapy and ImmunoPET
Autor: Brian Agnew, Brian M. Zeglis, Terry Zhang, Jessica Wang, Aimei Chen, Sai Kiran Sharma, Delphine Vivier, Pierre Adumeau
Publikováno v: Molecular Pharmaceutics. 15:892-898
The conjugation of antibodies with cytotoxic drugs can alter their in vivo pharmacokinetics. As a result, the careful assessment of the in vivo behavior — and specifically the tumor-targeting properties — of antibody-drug conjugates represents a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c16ad5a3711183608a02223e676852e
https://doi.org/10.1021/acs.molpharmaceut.7b00802
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10
Manipulating the In Vivo Behaviour of
Autor: Cinzia, Imberti, Pierre, Adumeau, Julia E, Blower, Fahad, Al Salemee, Julia, Baguña Torres, Jason S, Lewis, Brian M, Zeglis, Samantha Y A, Terry, Philip J, Blower
Publikováno v: International Journal of Molecular Sciences
Pretargeting is widely explored in immunoPET as a strategy to reduce radiation exposure of non-target organs and allow the use of short-lived radionuclides that would not otherwise be compatible with the slow pharmacokinetic profiles of antibodies. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f54b1fa1951ec2837fd367e8c6121de6
https://pubmed.ncbi.nlm.nih.gov/32098299
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