Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Piero Temperini"'
Autor:
Arturo Carabias, Anders Fuglsang, Piero Temperini, Tillmann Pape, Nicholas Sofos, Stefano Stella, Simon Erlendsson, Guillermo Montoya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The Class 2 family of CRISPR nucleases named Cas12j, which shares only low sequence identity with other CRISPR nucleases was recently identified in the biggiephage clade of phages. Here, the authors present the cryo-EM structure of a functional Cas12
Externí odkaz:
https://doaj.org/article/0c04ac7b346d45d1bfa7aa86df769b74
Autor:
Jacob C. Hansen, Silke Kayser, Kasper B. Hansen, Stylianos Iliadis, Niels Krogsgaard-Larsen, Lennart Bunch, Darryl S. Pickering, Jed T. Syrenne, Markus Staudt, Piero Temperini, Younes Larsen, Birgitte Nielsen, Feng Yi, Aleksandra Moroz
Publikováno v:
ACS Chemical Neuroscience. 11:674-701
Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b74894f5acdfe0a342e18b7b5c2a7a0e
https://doi.org/10.1021/acschemneuro.0c00003
https://doi.org/10.1021/acschemneuro.0c00003
Autor:
Guillermo Montoya, Tillmann Pape, Simon Erlendsson, Stefano Stella, Anders Fuglsang, Piero Temperini, Nicholas Sofos, Arturo Carabias
Publikováno v:
Nature Communications
Carabias, A, Fuglsang, A, Temperini, P, Pape, T, Sofos, N, Stella, S, Erlendsson, S & Montoya, G 2021, ' Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3 ', Nature Communications, vol. 12, 4476 . https://doi.org/10.1038/s41467-021-24707-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Carabias, A, Fuglsang, A, Temperini, P, Pape, T, Sofos, N, Stella, S, Erlendsson, S & Montoya, G 2021, ' Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3 ', Nature Communications, vol. 12, 4476 . https://doi.org/10.1038/s41467-021-24707-3
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
CRISPR-Cas12j is a recently identified family of miniaturized RNA-guided endonucleases from phages. These ribonucleoproteins provide a compact scaffold gathering all key activities of a genome editing tool. We provide the first structural insight int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380dfd70481600acb8e2ab65f51df601
http://europepmc.org/articles/PMC8298400
http://europepmc.org/articles/PMC8298400
Autor:
Silke, Kayser, Piero, Temperini, Christian B M, Poulie, Markus, Staudt, Birgitte, Nielsen, Darryl S, Pickering, Lennart, Bunch
Publikováno v:
ACS chemical neuroscience. 11(5)
Discovery of chemical tools for the ionotropic glutamate receptors continues to be a challenging task. Herein we report a diversity-oriented approach to new 2,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03bd751c3ff458e73fe94257411a4757
https://pubmed.ncbi.nlm.nih.gov/32069018
https://pubmed.ncbi.nlm.nih.gov/32069018
Autor:
Silke, Kayser, Jacob C, Hansen, Markus, Staudt, Aleksandra, Moroz, Younes, Larsen, Piero, Temperini, Feng, Yi, Jed T, Syrenne, Niels, Krogsgaard-Larsen, Stylianos, Iliadis, Birgitte, Nielsen, Kasper B, Hansen, Darryl S, Pickering, Lennart, Bunch
Publikováno v:
ACS Chem Neurosci
Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9854d2d039a9d944b85aa9789f222513
https://pubmed.ncbi.nlm.nih.gov/32065744
https://pubmed.ncbi.nlm.nih.gov/32065744
Autor:
Tommy N. Johansen, Birgitte Nielsen, Diletta Pasini, Darryl S. Pickering, Jakob S. Pallesen, Piero Temperini, Karla Frydenvang, Ana V. Paternain, Jette S. Kastrup, Stine Møllerud, Esmira Mamedova, Jesper T. Andreasen, Paulina Chalupnik, Juan Lerma, Rie Bager Hansen, Jan Bornholt, Marta Diaz-delCastillo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Selective pharmacological tool compounds are invaluable for understanding the functions of the various ionotropic glutamate receptor subtypes. For the kainate receptors, these compounds are few. Here we have synthesized nine novel quinoxaline-2,3-dio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161de92b3acdb6023d66230679d719f4
http://hdl.handle.net/10261/217920
http://hdl.handle.net/10261/217920
