A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo.

Autor: Angela M Jansen, Lindsay J Hall, Simon Clare, David Goulding, Kathryn E Holt, Andrew J Grant, Piero Mastroeni, Gordon Dougan, Robert A Kingsley

Publikováno v: PLoS Pathogens, Vol 7, Iss 7, p e1002131 (2011)

The Vi capsular polysaccharide is a virulence-associated factor expressed by Salmonella enterica serotype Typhi but absent from virtually all other Salmonella serotypes. In order to study this determinant in vivo, we characterised a Vi-positive S. Ty

Externí odkaz: https://doaj.org/article/1da18c4a960948a7a628da28e15dfc99

Dual role of splenic mononuclear and polymorphonuclear cells in the outcome of ciprofloxacin treatment of Salmonella enterica infections

Autor: Barbara Blacklaws, P Tonks, Piero Mastroeni, Panchali Kanvatirth, Omar Rossi, Andrew J. Grant, Olivier Restif

Publikováno v: The Journal of antimicrobial chemotherapy. 75(10)

Objectives To determine the immune cell populations associated with Salmonella enterica serovar Typhimurium before and after ciprofloxacin treatment using a murine model of systemic infection. The effect of depletion of immune cells associating with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80415c9edfebbe8b54be1382536ab62b
https://pubmed.ncbi.nlm.nih.gov/32613238

TARM1 Is a Novel Leukocyte Receptor Complex–Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils

Autor: Karsten Skjødt, Valeria Radjabova, Edwin R. Chilvers, Alexander D. Barrow, Bernard de Bono, Jane C. Goodall, Jatinder K. Juss, Des C. Jones, Piero Mastroeni, John Trowsdale, Paola Zaccone

Publikováno v: Radjabova, V, Mastroeni, P, Skjødt, K, Zaccone, P, de Bono, B, Goodall, J C, Chilvers, E R, Juss, J K, Jones, D C, Trowsdale, J & Barrow, A D 2015, ' TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils ', Journal of Immunology, vol. 195, no. 7, pp. 3149-3159 . https://doi.org/10.4049/jimmunol.1401847

We identified a novel, evolutionarily conserved receptor encoded within the human leukocyte receptor complex and syntenic region of mouse chromosome 7, named T cell–interacting, activating receptor on myeloid cells-1 (TARM1). The transmembrane regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e88727cb8071758fe749f3ff5fa744
https://doi.org/10.4049/jimmunol.1401847

Salmonella enterica serovar Typhimurium mutants completely lacking the F(0)F(1) ATPase are novel live attenuated vaccine strains

Autor: Helen Northen, Gavin K. Paterson, Fernando Constantino-Casas, Simon Clare, Duncan J. Maskell, S. E. Peters, Clare E. Bryant, Piero Mastroeni

Publikováno v: Vaccine

The F(0)F(1) ATPase plays a central role in both the generation of ATP and the utilisation of ATP for cellular processes such as rotation of bacterial flagella. We have deleted the entire operon encoding the F(0)F(1) ATPase, as well as genes encoding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb5cba0320ffdc6f1470d598861840d
https://pubmed.ncbi.nlm.nih.gov/19925904

Live attenuated Salmonella as a vector for oral cytokine gene therapy in melanoma

Autor: José A. Chabalgoity, Caroline Agorio, Mark Sheppard, Miguel Angel Martinez, Fernanda Schreiber, Piero Mastroeni, Marcelo Fernández

Publikováno v: The journal of gene medicine. 9(5)

Systemic administration of cytokines has shown therapeutic benefits in cancer patients; however, serious adverse effects associated with direct protein administration prevent the wide use of this approach. We have assessed the capacity of live attenu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e828c492df956ebec0e9c56f38a1c9
https://pubmed.ncbi.nlm.nih.gov/17410612