Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Piernicola Boccuni"'
Autor:
Donghoon Lee, Nagesh Kalakonda, Robert J. Sims, Danny Reinberg, Patrick Trojer, Yuh-Hwa Wang, Guohong Li, Piernicola Boccuni, Hediye Erdjument-Bromage, Stephen D. Nimer, Alejandro Vaquero, Paul Tempst
Publikováno v:
Cell. 129:915-928
Summary Distinct histone lysine methylation marks are involved in transcriptional repression linked to the formation and maintenance of facultative heterochromatin, although the underlying mechanisms remain unclear. We demonstrate that the m alignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b5dff37b68b2bec0e9717a248feb89
https://doi.org/10.1016/j.cell.2007.03.048
https://doi.org/10.1016/j.cell.2007.03.048
Publikováno v:
Blood. 109:3570-3578
Human hematopoietic stem cells (HSCs) exposed to cytokines in vitro rapidly divide and lose their characteristic functional properties presumably due to the alteration of a genetic program that determines the properties of an HSC. We have attempted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdafd8cf1db070a7000d5c76aea156c
https://doi.org/10.1182/blood-2006-07-035287
https://doi.org/10.1182/blood-2006-07-035287
Autor:
Abdulgabar Salama, Piernicola Boccuni, Karl Seeger, Gudrun Holland, Malcolm A.S. Moore, Javier Pinilla-Ibarz, Stephen D. Nimer, Anja Moldenhauer, Richard C. Frank, David A. Scheinberg
Publikováno v:
Journal of Leukocyte Biology. 76:623-633
Recurrent cytogenetic abnormalities in leukemic blasts make these an attractive source for dendritic cells (DC) to induce a leukemia-specific immune response. In this study, three leukemic cell lines were investigated: Kasumi-1 and SKNO-1 (two acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e9334054f3cc474999a2ad27c444ce
https://doi.org/10.1189/jlb.1103581
https://doi.org/10.1189/jlb.1103581
Autor:
Valentina Tereshko, Stephen D. Nimer, Piernicola Boccuni, Dinshaw J. Patel, Wooi Koon Wang, Donal MacGrogan
Publikováno v:
Structure. 11(7):775-789
We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ba2b4d297166a243a6cdbe0ef96ce9
Autor:
Hiroaki Kiyokawa, Piernicola Boccuni, Jin Zhang, Yasushi Miyazaki, Stephen D. Nimer, Paul Tempst, Hediye Erdjument-Bromage, Shifeng Mao
Publikováno v:
Journal of Biological Chemistry. 276:40528-40536
MEF, a recently identified member of the E74 family of ETS-related transcription factors, is a strong transcriptional activator of cytokine gene expression. Using a green fluorescent protein gene reporter plasmid regulated by an MEF-responsive promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10521e011fc39278b17345c9c396daf7
https://doi.org/10.1074/jbc.m103051200
https://doi.org/10.1074/jbc.m103051200
Autor:
Piernicola Boccuni, Xinyang Zhao, Nadia Gurvich, Donal MacGrogan, Stephen D. Nimer, Nagesh Kalakonda, J C Rice, Y Miyata, Wolfgang Fischle, J Zhang, Ruben Hoya-Arias, Jennifer K. Sims
Publikováno v:
Oncogene. 27(31)
Lethal 3 malignant brain tumor 1 (L3MBTL1), a homolog of the Drosophila polycomb tumor suppressor l(3)mbt, contains three tandem MBT repeats (3xMBT) that are critical for transcriptional repression. We recently reported that the 3xMBT repeats interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400f658a4682e811e9c7842a0793c4cd
https://pubmed.ncbi.nlm.nih.gov/18408754
https://pubmed.ncbi.nlm.nih.gov/18408754
Autor:
Vladimir Jankovic, Alessia Ciarrocchi, Stephen D. Nimer, Piernicola Boccuni, Tony DeBlasio, Robert Benezra
Appropriate hematopoietic stem cell (HSC) self-renewal reflects the tight regulation of cell cycle entry and lineage commitment. Here, we show that Id1, a dominant-negative regulator of E protein transcription factors, maintains HSC self-renewal by p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef2339aa7d970ab233c2a2e28043516
https://europepmc.org/articles/PMC1783103/
https://europepmc.org/articles/PMC1783103/
Publikováno v:
Critical reviews in eukaryotic gene expression. 16(2)
The hematopoietic stem cell (HSC) has the potential to differentiate into mature cells with distinct phenotypes and functions. As suggested in recent reports, this plasticity can expand to include nonhematopoietic lineages, and, indeed, the HSC may r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7c8f6463030fe5ed76c81cc47d32dc
https://pubmed.ncbi.nlm.nih.gov/16749897
https://pubmed.ncbi.nlm.nih.gov/16749897
Transforming growth factor β (TGFβ) is one of few known negative regulators of hematopoiesis, yet the mechanisms by which it affects cell cycle arrest and stem cell quiescence are poorly understood. Induction of the cyclin-dependent kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4e51603ec1eb176d18e3a031e19e27
https://europepmc.org/articles/PMC524079/
https://europepmc.org/articles/PMC524079/
Autor:
Stephen D. Nimer, Donal MacGrogan, Piernicola Boccuni, Joseph M. Scandura, Bertil Johansson, Sara Alvarez, Nagesh Kalakonda
Publikováno v:
Genes, chromosomescancer. 41(3)
The human L3MBTL gene is located in 20q12, a region that is commonly deleted in myeloproliferative disorders (MPD), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). L3MBTL is highly homologous to the D-lethal(3) malignant brain tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c65f8c65a4d9e9595e1334cce8d514
https://pubmed.ncbi.nlm.nih.gov/15334543
https://pubmed.ncbi.nlm.nih.gov/15334543