Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Piermichele Kobauri"'
Autor:
Anna I. Lauxen, Piermichele Kobauri, Michael Wegener, Mickel J. Hansen, Nicole S. Galenkamp, Giovanni Maglia, Wiktor Szymanski, Ben L. Feringa, Oscar P. Kuipers
Publikováno v:
Pharmaceuticals, Vol 14, Iss 5, p 392 (2021)
During the last decades, a continuous rise of multi-drug resistant pathogens has threatened antibiotic efficacy. To tackle this key challenge, novel antimicrobial therapies are needed with increased specificity for the site of infection. Photopharmac
Externí odkaz:
https://doaj.org/article/b266258da77d4777a95ca5db1a47d547
Publikováno v:
Angewandte Chemie International Edition.
Autor:
Martin D. Witte, Sebastian Thallmair, Ben L. Feringa, Piermichele Kobauri, Siewert J. Marrink, Wiktor Szymanski, Frank J. Dekker, Fangyuan Cao
Publikováno v:
Chemical Communications
Chemical Communications, 57(34), 4126-4129. ROYAL SOC CHEMISTRY
Chemical Communications, 57(34), 4126-4129. ROYAL SOC CHEMISTRY
Biaryl sulfonamides are excellent candidates for the azologization approach that yields photoswitchable drugs more active in their metastable cis state, compared to the stable trans state. Here we present the scope and limitations of this strategy fo
Autor:
Piermichele Kobauri
Photopharmacology uses light to regulate the biological activity of drugs. This precise control is obtained through the incorporation of molecular photoswitches into bioactive molecules. A major challenge for photopharmacology is the rational design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163306528c8ed4eaa299d3455221a85a
https://doi.org/10.33612/diss.213323038
https://doi.org/10.33612/diss.213323038
Autor:
Michael Kathan, Stefano Crespi, Niklas O. Thiel, Daniel L. Stares, Denis Morsa, John de Boer, Gianni Pacella, Tobias van den Enk, Piermichele Kobauri, Giuseppe Portale, Christoph A. Schalley, Ben L. Feringa
Publikováno v:
Nature Nanotechnology, 17, 159-165. Nature Publishing Group
Nature Nanotechnology
Nature Nanotechnology
Biological molecular machines enable chemical transformations, assembly, replication and motility, but most distinctively drive chemical systems out of-equilibrium to sustain life1,2. In such processes, nanometre-sized machines produce molecular ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9301611be96c9128c74379d22f74bc0
https://research.rug.nl/en/publications/c204f7cc-f94f-42f7-9e46-1fe03949bbf6
https://research.rug.nl/en/publications/c204f7cc-f94f-42f7-9e46-1fe03949bbf6
Autor:
Wiktor Szymanski, Anja P Huizing, Gert Luurtsema, Douwe F. Samplonius, Philip H. Elsinga, Ben L. Feringa, Hugo Helbert, Wijnand Helfrich, Marten Klopstra, Ton J. Visser, Dion van der Born, Jurgen W. A. Sijbesma, Verena I. Böhmer, Piermichele Kobauri, Keimpe-Oeds van den Berg, Inês Antunes, Friederike Reeβing, Chantal Mulder
Publikováno v:
Chemistry – A European Journal
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry, 26(47), 10871-10881. Wiley-VCH Verlag GmbH & Co. KGaA
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry, 26(47), 10871-10881. Wiley-VCH Verlag GmbH & Co. KGaA
Since the seminal contribution of Rolf Huisgen to develop the [3+2] cycloaddition of 1,3‐dipolar compounds, its azide–alkyne variant has established itself as the key step in numerous organic syntheses and bioorthogonal processes in materials sci
Autor:
Piermichele Kobauri, Nicole S. Galenkamp, Albert M. Schulte, Jisk de Vries, Nadja A. Simeth, Giovanni Maglia, Sebastian Thallmair, Dušan Kolarski, Wiktor Szymanski, Ben L. Feringa
Publikováno v:
Journal of medicinal chemistry 65(6), 4798-4817 (2022). doi:10.1021/acs.jmedchem.1c01962
Journal of Medicinal Chemistry, 65(6):1c01962, 4798-4817. AMER CHEMICAL SOC
Journal of Medicinal Chemistry, 65(6):1c01962, 4798-4817. AMER CHEMICAL SOC
Journal of medicinal chemistry 65(6), 4798-4817 (2022). doi:10.1021/acs.jmedchem.1c01962
Published by ACS, Washington, DC
Published by ACS, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c519cf2b0fd8822127b1ea7e47cd79cf
https://publications.rwth-aachen.de/record/848560
https://publications.rwth-aachen.de/record/848560
Autor:
Nadja A. Simeth, Chikara Dohno, Kazuhiko Nakatani, Shotaro Kobayashi, Wiktor Szymanski, Ben L. Feringa, Piermichele Kobauri, Stefano Crespi
Publikováno v:
Chemical Science, 12(26), 9207-9220. ROYAL SOC CHEMISTRY
Chemical Science
Chemical Science
Short, complementary DNA single strands with mismatched base pairs cannot undergo spontaneous formation of duplex DNA (dsDNA). Mismatch binding ligands (MBLs) can compensate this effect, inducing the formation of the double helix and thereby acting a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568e5c2e593f5e256ecfc9157696f98f
https://research.rug.nl/en/publications/39f9f43d-cd29-4253-a918-8ec3f9ee9a66
https://research.rug.nl/en/publications/39f9f43d-cd29-4253-a918-8ec3f9ee9a66
Autor:
Maria E. Ourailidou, Frank J. Dekker, Wiktor Szymanski, Petra E van der Wouden, Piermichele Kobauri, Christian Peifer, Malte Kriegs, Theo Rodat, Ben L. Feringa, Mark W. H. Hoorens
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 179, 133-146. ELSEVIER MASSON, CORPORATION OFFICE
European Journal of Medicinal Chemistry, 179, 133-146. ELSEVIER MASSON, CORPORATION OFFICE
Metastatic melanoma is amongst the most difficult types of cancer to treat, with current therapies mainly relying on the inhibition of the BRAFV600E mutant kinase. However, systemic inhibition of BRAF by small molecule drugs in cancer patients result
Autor:
Piermichele, Kobauri, Wiktor, Szymanski, Fangyuan, Cao, Sebastian, Thallmair, Siewert J, Marrink, Martin D, Witte, Frank J, Dekker, Ben L, Feringa
Publikováno v:
Chemical communications (Cambridge, England). 57(34)
Biaryl sulfonamides are excellent candidates for the azologization approach that yields photoswitchable drugs more active in their metastable cis state, compared to the stable trans state. Here we present the scope and limitations of this strategy fo