Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Pierluigi, Nicotera"'
Autor:
Lena Wischhof, Amal John Mathew, Lorenzo Bonaguro, Marc Beyer, Dan Ehninger, Pierluigi Nicotera, Daniele Bano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Inhibition of the mitochondrial oxidative phosphorylation (OXPHOS) system can lead to metabolic disorders and neurodegenerative diseases. In primary mitochondrial disorders, reactive astrocytes often accompany neuronal degeneration and may c
Externí odkaz:
https://doaj.org/article/9f5d2292caf04a5db7cbda1f09301ca7
Autor:
Damiana Scuteri, Martina Pagliaro, Isabel Mantia, Marianna Contrada, Loris Pignolo, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta, Maria Tiziana Corasaniti, the Pilot BRAINAID Trial investigators
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundAn estimated 57.4 million people live with dementia worldwide, with the social burden of the disease steadily growing. Despite the approval of lecanemab and ongoing trials, there is still a lack of effective and safe treatments for behavior
Externí odkaz:
https://doaj.org/article/f3e9bb65986f482fb4055b3dadaa8737
Autor:
Joshua Jackson, Christian Hoffmann, Enzo Scifo, Han Wang, Lena Wischhof, Antonia Piazzesi, Mrityunjoy Mondal, Hanna Shields, Xuesi Zhou, Magali Mondin, Eanna B. Ryan, Hermann Döring, Jochen H. M. Prehn, Klemens Rottner, Gregory Giannone, Pierluigi Nicotera, Dan Ehninger, Dragomir Milovanovic, Daniele Bano
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well documented that the reversible liquid-liq
Externí odkaz:
https://doaj.org/article/997bb81463e54820a4534745f1061001
Autor:
Damiana Scuteri, Daniele Pierobon, Martina Pagliaro, Kengo Hamamura, Takafumi Hayashi, Loris Pignolo, Pierluigi Nicotera, Giacinto Bagetta, Maria Tiziana Corasaniti
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1253 (2024)
Background: According to scientific literature, some 99% of patients affected by Alzheimer’s disease (AD) suffer from behavioral and psychological symptoms of dementia (BPSD), also known as neuropsychiatric symptoms (NPSs). In particular, agitation
Externí odkaz:
https://doaj.org/article/6574508b753d49a28f7d549fbdad2ac0
Autor:
Damiana Scuteri, Giulio Pocobelli, Yoichi Sakurada, Rossella Russo, Paolo Tonin, Pierluigi Nicotera, Giacinto Bagetta, Maria Tiziana Corasaniti, Carlo Nucci
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract The social impact of glaucoma is worth of note: primary open-angle glaucoma (POAG) is one of the leading causes of irreversible blindness worldwide, affecting some 68.56 million people with overall prevalence of 2.4%. Since one of the main r
Externí odkaz:
https://doaj.org/article/4f6a878de29a425e9d1e334984d3bae7
Publikováno v:
The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background the interest of clinical reaseach in polymorphisms and epigenetics in migraine has been growing over the years. Due to the new era of preventative migraine treatment opened by monoclonal antibodies (mAbs) targeting the signaling o
Externí odkaz:
https://doaj.org/article/59e144e057da44e2966ba9b3cfc78fc3
Autor:
Maria Tiziana Corasaniti, Giacinto Bagetta, Pierluigi Nicotera, Assunta Tarsitano, Paolo Tonin, Giorgio Sandrini, Gary W. Lawrence, Damiana Scuteri
Publikováno v:
Toxins, Vol 15, Iss 5, p 332 (2023)
Some 14% of global prevalence, based on high-income country populations, suffers from migraine. Chronic migraine is very disabling, being characterized by at least 15 headache days per month of which at least 8 days present the features of migraine.
Externí odkaz:
https://doaj.org/article/0d0d33eaad004337a8618bec486b9446
Autor:
Joshua Jackson, Lena Wischhof, Enzo Scifo, Anna Pellizzer, Yiru Wang, Antonia Piazzesi, Debora Gentile, Sana Siddig, Miriam Stork, Chris E. Hopkins, Kristian Händler, Joachim Weis, Andreas Roos, Joachim L. Schultze, Pierluigi Nicotera, Dan Ehninger, Daniele Bano
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101503- (2022)
Objective: Mitochondrial “retrograde” signaling may stimulate organelle biogenesis as a compensatory adaptation to aberrant activity of the oxidative phosphorylation (OXPHOS) system. To maintain energy-consuming processes in OXPHOS deficient cell
Externí odkaz:
https://doaj.org/article/9d8b2a62ba88416c9f9326255683b183
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundStroke is one of the most frequent causes of death and disability worldwide. It is accompanied by the impaired motor function of the upper extremities in over 69% of patients up to hemiplegia in the following 5 years in 56% of cases. This c
Externí odkaz:
https://doaj.org/article/593fc216c787419fb98d0038bbe1dbea
Autor:
Damiana Scuteri, Paolo Tonin, Pierluigi Nicotera, Marilù Vulnera, Giuseppina Cristina Altieri, Assunta Tarsitano, Giacinto Bagetta, Maria Tiziana Corasaniti
Publikováno v:
Toxins, Vol 14, Iss 8, p 529 (2022)
OnabotulinumtoxinA, targeting the CGRP machinery, has been approved for the last two decades for chronic migraine prevention. The recently approved monoclonal antibodies (mAbs) directed towards the calcitonin gene-related peptide (CGRP) pathway open
Externí odkaz:
https://doaj.org/article/7f1887815d84473cb877281d05be3cf1