Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pierfrancesco Orlando"'
Autor:
Philipp C. Kohler, Andreas Heine, Tina Ritschel, Luzi Jakob Barandun, Gerhard Klebe, F. Immekus, Pierfrancesco Orlando, François Diederich
Publikováno v:
Acta Crystallographica Section D-Biological Crystallography, 69, Pt 9, pp. 1798-807
Acta Crystallographica Section D-Biological Crystallography, 69, 1798-807
Acta Crystallographica Section D-Biological Crystallography, 69, 1798-807
The tRNA-modifying enzyme tRNA–guanine transglycosylase (TGT) has been recognized as a drug target for the treatment of the foodborne illness shigellosis. The active site of TGT consists of three pockets: the central guanine/preQ1 recognition sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d6e708107942022fbcf0ded5479492
https://doi.org/10.1107/s0907444913014509
https://doi.org/10.1107/s0907444913014509
Autor:
Annalida Bedini, Gilberto Spadoni, Valeria Lucini, Simone Lucarini, Silvia Rivara, Pierfrancesco Orlando, Marilou Pannacci, Giorgio Tarzia, Francesco Scaglione, Marco Mor
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4910-4916
We report the synthesis, binding properties and intrinsic activity at MT(1) and MT(2) melatonin receptors of new dimeric melatonin receptor ligands in which two units of the monomeric agonist N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide (1) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8a3d6a58b8fc5e0115543bd2dc5818
https://doi.org/10.1016/j.bmc.2011.06.063
https://doi.org/10.1016/j.bmc.2011.06.063
Autor:
Silvia Bartolucci, Pierfrancesco Orlando, Gilberto Spadoni, Giuseppe Gatti, Giovanni Piersanti, Simone Lucarini, Annalida Bedini
An efficient and practical approach for the synthesis of all four stereoisomers of the MT2 melatonin receptor ligand 4-phenyl-2-propionamidotetralin (4-P-PDOT), each in enantiomerically pure form (ee > 99.9%), was developed. The strategy involved an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1e0a6c6fb10858d47672fac6567e40
https://hdl.handle.net/11576/2510243
https://hdl.handle.net/11576/2510243
Autor:
Giorgio Tarzia, Annalida Bedini, Claudia Silva, Marilou Pannacci, Alessandro Fioni, Silvia Rivara, Gilberto Spadoni, Alessia Caronno, Valeria Lucini, Pierfrancesco Orlando, Federica Vacondio, Gabriella Gobbi, Marco Mor, Caterina Carmi, Francesco Scaglione, Simone Lucarini
The class of N-(anilinoethyl)amides includes melatonin receptor ligands with varied subtype selectivity and intrinsic activity. One of these ligands, the MT(2)-selective partial agonist UCM765 (N-{2-[(3-methoxyphenyl)phenylamino]ethyl}acetamide), had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497771846c4eb5100ee3d044c1bcb321
https://hdl.handle.net/11576/2504142
https://hdl.handle.net/11576/2504142
Autor:
Giovanni Piersanti, Vieri Fusi, Giovanni Zappia, Eleonora Macedi, Patrizia Rossi, Mauro Formica, Paola Paoli, Pierfrancesco Orlando
The synthesis and characterization of the two new hosting molecules for anions 4(N),10(N)-bis-[2-(4-nitrophenylureido)acetamido]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane (L1) and 1-((diethylcarbamoyl)methyl)-3-(4-nitrophenyl)urea (L2) are reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9799dae70967c19bbc7f776d595bffba
https://hdl.handle.net/11576/1887579
https://hdl.handle.net/11576/1887579
Autor:
Mauro Formica, Vieri Fusi, Eleonora Macedi, Paola Paoli, Giovanni Piersanti, Patrizia Rossi, Giovanni Zappia, Pierfrancesco Orlando
Publikováno v:
New Journal of Chemistry; Jul2008, Vol. 32 Issue 7, p1204-1214, 11p