Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Pierfrancesco, Pagella"'
Autor:
Pierfrancesco Pagella, Chai Foong Lai, Laurence Pirenne, Claudio Cantù, Martin E. Schwab, Thimios A. Mitsiadis
Publikováno v:
International Journal of Oral Science, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Neurite outgrowth inhibitor A (Nogo-A) is a major player in neural development and regeneration and the target of clinical trials aiming at promoting the regeneration of the central nervous system upon traumatic and ischemic injury. In this
Externí odkaz:
https://doaj.org/article/7a38e332226d460cab7be7e913df6316
Autor:
Pierfrancesco Pagella, Chai Foong Lai, Laurence Pirenne, Claudio Cantù, Martin E. Schwab, Thimios A. Mitsiadis
Publikováno v:
International Journal of Oral Science, Vol 16, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0e851615e72b4565a6533056e360a362
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is an increasingly popular technique to map genome-wide binding profiles of histone modifications, transcription factors, and co-factors. The ENCODE project and others ha
Externí odkaz:
https://doaj.org/article/186487b8127e425a89cf1cb77949d05f
Autor:
Anamaria Balic, Dilara Perver, Pierfrancesco Pagella, Hubert Rehrauer, Bernd Stadlinger, Andreas E. Moor, Viola Vogel, Thimios A. Mitsiadis
Publikováno v:
International Journal of Oral Science, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Carious lesions are bacteria-caused destructions of the mineralised dental tissues, marked by the simultaneous activation of immune responses and regenerative events within the soft dental pulp tissue. While major molecular players in tooth
Externí odkaz:
https://doaj.org/article/67124b26f1804da2806dfb211a557197
Autor:
Pierfrancesco Pagella, Laura deVargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 10, Pp 1433-1445 (2021)
Abstract The Notch signaling pathway is a fundamental regulator of cell fate determination in homeostasis and regeneration. In this work, we aimed to determine how Notch signaling mediates the interactions between perivascular stem cells and their ni
Externí odkaz:
https://doaj.org/article/5f7843a74d9c4f86a5b1e0aa634ca8c0
Autor:
Thimios A. Mitsiadis, Lucia Jimenez-Rojo, Anamaria Balic, Silvio Weber, Paul Saftig, Pierfrancesco Pagella
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105154- (2022)
Summary: The disintegrin and metalloproteinase Adam10 is a membrane-bound sheddase that regulates Notch signaling and ensures epidermal integrity. To address the function of Adam10 in the continuously growing incisors, we used Keratin14Cre/+;Adam10fl
Externí odkaz:
https://doaj.org/article/2bef9521aac44f0389397a98e8516878
Autor:
Thimios A. Mitsiadis, Pierfrancesco Pagella, Helder Gomes Rodrigues, Alexander Tsouknidas, Liza L. Ramenzoni, Freddy Radtke, Albert Mehl, Laurent Viriot
Publikováno v:
Cells, Vol 12, Iss 5, p 761 (2023)
Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most d
Externí odkaz:
https://doaj.org/article/a509af65e7b84bde8d38f16fd1a37e85
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100953- (2021)
Summary: Teeth and the surrounding periodontal tissues are affected by many pathologies that compromise their integrity and significantly affect life quality. The study of the main dental tissues, the dental pulp and periodontium, is made arduous by
Externí odkaz:
https://doaj.org/article/5f01691802804519a6e10b2223ef16c5
Autor:
Chai Foong Lai, Juliet Shen, Anamaria Balic, Pierfrancesco Pagella, Martin E. Schwab, Thimios A. Mitsiadis
Publikováno v:
Cells, Vol 11, Iss 21, p 3415 (2022)
Human teeth are highly innervated organs that contain a variety of mesenchymal stem cell populations that could be used for cell-based regenerative therapies. Specific molecules are often used in these treatments to favorably modulate the function an
Externí odkaz:
https://doaj.org/article/dfbfb8cfb7b14cb9a7330a0747518439
Autor:
Pierfrancesco Pagella, Laura de Vargas Roditi, Bernd Stadlinger, Andreas E. Moor, Thimios A. Mitsiadis
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102405- (2021)
Summary: Teeth exert fundamental functions related to mastication and speech. Despite their great biomedical importance, an overall picture of their cellular and molecular composition is still missing. In this study, we have mapped the transcriptiona
Externí odkaz:
https://doaj.org/article/f87fbda8b7ac4d2999c72f9b5ce35784