Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Pierfausto Seneci"'
Autor:
Elisa Facen, Giulia Assoni, Greta Donati, Dalila Paladino, Agata Carreira, Isabelle Bonomo, Valeria La Pietra, Roberta Lotti, Josef Houser, Luca L. Fava, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Alessandro Provenzani
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The RNA binding protein Human Antigen R (HuR) has been identified as a main regulator of the innate immune response and its inhibition can lead to beneficial anti-inflammatory effects. To this aim, we previously synthesized a novel class of
Externí odkaz:
https://doaj.org/article/bdf3a13a957a4cdb8e0be0dcf65c60d7
Autor:
Andrea Balboni, Camilla D’Angelo, Nicoletta Collura, Simone Brusco, Claudia Di Berardino, Altea Targa, Beatrice Massoti, Eloise Mastrangelo, Mario Milani, Pierfausto Seneci, Vania Broccoli, Luca Muzio, Rossella Galli, Andrea Menegon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Glioblastoma (GBM) is the most common malignant primary brain cancer that, despite recent advances in the understanding of its pathogenesis, remains incurable. GBM contains a subpopulation of cells with stem cell-like properties called cance
Externí odkaz:
https://doaj.org/article/d2425d752d414824a5eee89bb1c78547
Autor:
Elisa Fagnani, Francesco Bonì, Pierfausto Seneci, Davide Gornati, Luca Muzio, Eloise Mastrangelo, Mario Milani
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1088-1093 (2024)
The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone 2a as an effective new compound for the treatment of amyotrophic l
Externí odkaz:
https://doaj.org/article/1cd32817805240faa098c6e2c29a04ba
Autor:
Greta Donati, Vincenzo Maria D’Amore, Pasquale Russomanno, Linda Cerofolini, Jussara Amato, Simona Marzano, Maria Salobehaj, Domenico Rizzo, Giulia Assoni, Alfonso Carotenuto, Valeria La Pietra, Daniela Arosio, Pierfausto Seneci, Marco Fragai, Diego Brancaccio, Francesco Saverio Di Leva, Luciana Marinelli
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3355-3368 (2023)
Today it is widely recognized that the PD-1/PD-L1 axis plays a fundamental role in escaping the immune system in cancers, so that anti-PD-1/PD-L1 antibodies have been evaluated for their antitumor properties in more than 1000 clinical trials. As a re
Externí odkaz:
https://doaj.org/article/3bd14ba4f0aa401ca2a63ca4a266835e
Autor:
Marina Saresella, Chiara Paola Zoia, Francesca La Rosa, Chiara Bazzini, Gessica Sala, Erica Grassenis, Ivana Marventano, Ambra Hernis, Federica Piancone, Elisa Conti, Silvia Sesana, Francesca Re, Pierfausto Seneci, Carlo Ferrarese, Mario Clerici
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1725 (2023)
Activation of the NLRP3 inflammasome in response to either exogenous (PAMPs) or endogenous (DAMPs) stimuli results in the production of IL-18, caspase-1 and IL-1β. These cytokines have a beneficial role in promoting inflammation, but an excessive ac
Externí odkaz:
https://doaj.org/article/7111cfb9c9e441f9929089bea51a62a2
Autor:
Isabelle Bonomo, Giulia Assoni, Valeria La Pietra, Giulia Canarutto, Elisa Facen, Greta Donati, Chiara Zucal, Silvia Genovese, Mariachiara Micaelli, Anna Pérez-Ràfols, Sergio Robbiati, Dimitris L. Kontoyannis, Marilenia De Matteo, Marco Fragai, Pierfausto Seneci, Luciana Marinelli, Daniela Arosio, Silvano Piazza, Alessandro Provenzani
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/f46f5530b8b347c99a98e099c85d727f
Autor:
Roberta Mancuso, Lorenzo Agostino Citterio, Simone Agostini, Ivana Marventano, Francesca La Rosa, Francesca Re, Pierfausto Seneci, Marina Saresella, Mario Clerici
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1590 (2023)
The anti-hyperglycemic drug glibenclamide (Glb) might represent an interesting therapeutic option in human neurodegenerative diseases because of its anti-inflammatory activity and its ability to downregulate activation of the NLRP3 inflammasome. Bi-f
Externí odkaz:
https://doaj.org/article/83e7acefbe9c41a59dedbefab4f41aa6
Autor:
Eleonora Colombo, Stefania Olla, Cristina Minnelli, Alessia Formato, Caterina Veroni, Silvia Corbisiero, Mattia Pericolo, Chiara Siguri, Giovanna Mobbili, Cristina Agresti, Pierfausto Seneci
Publikováno v:
Molecules, Vol 28, Iss 19, p 6928 (2023)
Edaravone (EDA), an antioxidant drug approved for the treatment of ischemic stroke and amyotrophic lateral sclerosis, was recently proposed as a remyelinating candidate for the treatment of multiple sclerosis. Here, we synthesized twelve EDA analogue
Externí odkaz:
https://doaj.org/article/36e8ab7190cd4688b7643ce4f6e5c262
Autor:
Antonia I. Antoniou, Giulia Nordio, Maria Luisa Di Paolo, Eleonora Colombo, Beatrice Gaffuri, Laura Polito, Arianna Amenta, Pierfausto Seneci, Lisa Dalla Via, Dario Perdicchia, Daniele Passarella
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 722 (2023)
A potent nontoxic antitumor drug, 2-hydroxyoleic acid (6, 2OHOA) used for membrane lipid therapy, was selected as a self-assembly inducer due to its ability to form nanoparticles (NPs) in water. For this purpose, it was conjugated with a series of an
Externí odkaz:
https://doaj.org/article/989a683bcee348109029a8979ddd23b4
Autor:
Martina Pedrini, Angelo Iannielli, Lorenzo Meneghelli, Daniele Passarella, Vania Broccoli, Pierfausto Seneci
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1467 (2023)
The search for disease-modifying agents targeted against Parkinson’s disease led us to rationally design a small array of six Anle138b-centered PROTACs, 7a,b, 8a,b and 9a,b, targeting αSynuclein (αSyn) aggregates for binding, polyubiquitination b
Externí odkaz:
https://doaj.org/article/891a2a22e7a74a898474afba10a7f648