Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Pierce Ogden"'
Autor:
Drew Bryant, Patrick Riley, Ali Bashir, Nina Jain, Sam Sinai, Eric D. Kelsic, George M. Church, Pierce Ogden, Lucy J. Colwell
Publikováno v:
Nature Biotechnology. 39:691-696
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data wi
Publikováno v:
Science
The fitness landscape of AAV Adeno-associated virus (AAV) is an important gene therapy vector. Using tools from synthetic biology, Ogden et al. provide a comprehensive view of how sequence changes in capsid proteins affect AAV properties. After satur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b541b24fddf7411950fd9ad1de5f7da1
https://europepmc.org/articles/PMC7197022/
https://europepmc.org/articles/PMC7197022/
Autor:
Pierce Ogden, Nicholas Conway, George M. Church, Ryan P. Adams, Gleb Kuznetsov, Surojit Biswas
Proteins—molecular machines that underpin all biological life—are of significant therapeutic and industrial value. Directed evolution is a high-throughput experimental approach for improving protein function, but has difficulty escaping local max
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d18c9a74c357b85aaab43421457bca
Autor:
Christian Ottmann, Julia Davies, Christopher G. Wilson, Adam R. Renslo, K.K. Hallenbeck, Pierce Ogden, Michelle R. Arkin, Connie Merron, Eline Sijbesma
Publikováno v:
SLAS discovery : advancing life sciences R & D, vol 23, iss 2
SLAS Discovery, 23(2), 183-192. SAGE Publications Ltd
SLAS Discovery, 23(2), 183-192. SAGE Publications Ltd
We report the refinement of a high-throughput, liquid-chromatography/mass spectrometry (LC/MS)-based screening method for the identification of covalent small-molecule binders to proteins. Using a custom library of 1600 disulfide-capped fragments tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33613e435610f76e889d0cc65056f383
https://doi.org/10.1101/138941
https://doi.org/10.1101/138941
Publikováno v:
Journal of Heterocyclic Chemistry; Aug1974, Vol. 11 Issue 4, p563-568, 6p
Autor:
Pierce, Ogden R., Kim, Yung K.
Publikováno v:
Journal of Elastomers & Plastics; Apr1971, Vol. 3 Issue 2, p82-96, 15p
Maleic Anhydride Derivatives: Reactions of the Double Bond Lawrence H. Flett William Howlett Gardner
Autor:
Pierce, Ogden R.
Publikováno v:
Science, 1953 Mar . 117(3039), 342-342.
Externí odkaz:
https://www.jstor.org/stable/1680908
Autor:
Pierce, Ogden R.
Publikováno v:
The Scientific Monthly, 1952 Jan 01. 74(1), 58-58.
Externí odkaz:
https://www.jstor.org/stable/20850
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Steward, Omar W., Pierce, Ogden R.
Publikováno v:
In Journal of Organometallic Chemistry 1965 4(2):138-144