Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Pierce Kah‐Hoe Chow"'
Autor:
Do Young Kim, Bao Nguyen Toan, Chee-Kiat Tan, Irsan Hasan, Lyana Setiawan, Ming-Lung Yu, Namiki Izumi, Nguyen Nguyen Huyen, Pierce Kah-Hoe Chow, Rosmawati Mohamed, Stephen Lam Chan, Tawesak Tanwandee, Teng-Yu Lee, Thi Thanh Nguyen Hai, Tian Yang, Woo-Chang Lee, Henry Lik Yuen Chan
Publikováno v:
Clinical and Molecular Hepatology, Vol 29, Iss 2, Pp 277-292 (2023)
Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree o
Externí odkaz:
https://doaj.org/article/939b6e7180de46e9a686c87a0401fd8b
Autor:
Ah-Jung Jeon, Chukwuemeka George Anene-Nzelu, Yue-Yang Teo, Shay Lee Chong, Karthik Sekar, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Alexander Yaw Fui Chung, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D. dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K.P. Goh, Roger Sik Yin Foo, Pierce Kah-Hoe Chow
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100715- (2023)
Background & Aims: Lifestyle and environmental-related exposures are important risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation significantly underpins HCC. We profiled 30 surgically resected tumours and the m
Externí odkaz:
https://doaj.org/article/60b0d493517247318069a8fdb601a422
Autor:
Sang-Yun Lee, Yvonne Teng, Miseol Son, Bosung Ku, Ho Sang Moon, Vinay Tergaonkar, Pierce Kah-Hoe Chow, Dong Woo Lee, Do-Hyun Nam
Publikováno v:
PLoS ONE, Vol 18, Iss 12, p e0295827 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0251998.].
Externí odkaz:
https://doaj.org/article/a6955d48b8ff461985f3c33b9a93800d
Autor:
Dexter Kai Hao Thng, Tan Boon Toh, Paolo Pigini, Lissa Hooi, Yock Young Dan, Pierce Kah‐Hoe Chow, Glenn Kunnath Bonney, Masturah Bte Mohd Abdul Rashid, Ernesto Guccione, Dave Keng Boon Wee, Edward Kai‐Hua Chow
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Deregulation of MYC is among the most frequent oncogenic drivers in hepatocellular carcinoma (HCC). Unfortunately, the clinical success of MYC‐targeted therapies is limited. Synthetic lethality offers an alternative therapeutic strategy by
Externí odkaz:
https://doaj.org/article/77b9e0909c8e44a4a3b1672a0d0ade9b
Autor:
Muhammad Raihan Jumat, Pierce Kah-Hoe Chow, John Carson Allen, Siang Hui Lai, Nian-Chih Hwang, Jabed Iqbal, May Un Sam Mok, Attilio Rapisarda, John Matthew Velkey, Deborah Lynn Engle, Scott Compton
Publikováno v:
BMC Medical Education, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Burnout is a serious issue plaguing the medical profession with potential negative consequences on patient care. Burnout symptoms are observed as early as medical school. Based on a Job Demands-Resources model, this study aims to
Externí odkaz:
https://doaj.org/article/f49b0790f73d48b1b8676d59cd848c75
Autor:
Yu Jin, Wai Yeow Lee, Soo Ting Toh, Chandana Tennakoon, Han Chong Toh, Pierce Kah-Hoe Chow, Alexander Y.-F. Chung, Samuel S. Chong, London L.-P.-J. Ooi, Wing-Kin Sung, Caroline G.-L. Lee
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background Hepatocellular carcinoma is the second most deadly cancer with late presentation and limited treatment options, highlighting an urgent need to better understand HCC to facilitate the identification of early-stage biomarkers and un
Externí odkaz:
https://doaj.org/article/6c26ddd30b8844ce8595ebdb5c208db6
Autor:
Sang-Yun Lee, Yvonne Teng, Miseol Son, Bosung Ku, Ho Sang Moon, Vinay Tergaonkar, Pierce Kah-Hoe Chow, Dong Woo Lee, Do-Hyun Nam
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0251998 (2021)
To test the safety and efficacy of drugs via a high does drug heat map, a multi-spheroids array chip was developed by adopting a micropillar and microwell structure. In the chip, patient-derived cells were encapsulated in alginate and grown to maturi
Externí odkaz:
https://doaj.org/article/f2fe7c345938427ea3f638db3eb1843d
Autor:
Oleg V. Grinchuk, Surya P. Yenamandra, Ramakrishnan Iyer, Malay Singh, Hwee Kuan Lee, Kiat Hon Lim, Pierce Kah‐Hoe Chow, Vladamir A. Kuznetsov
Publikováno v:
Molecular Oncology, Vol 12, Iss 1, Pp 89-113 (2018)
Currently, molecular markers are not used when determining the prognosis and treatment strategy for patients with hepatocellular carcinoma (HCC). In the present study, we proposed that the identification of common pro‐oncogenic pathways in primary
Externí odkaz:
https://doaj.org/article/85d8138a6a0a444a99c4a294dae16252
Three-Dimensional Aggregated Spheroid Model of Hepatocellular Carcinoma Using a 96-Pillar/Well Plate
Autor:
Sang-Yun Lee, Yvonne Teng, Miseol Son, Bosung Ku, Hyun Ju Hwang, Vinay Tergaonkar, Pierce Kah-Hoe Chow, Dong Woo Lee, Do-Hyun Nam
Publikováno v:
Molecules, Vol 26, Iss 16, p 4949 (2021)
A common method of three-dimensional (3D) cell cultures is embedding single cells in Matrigel. Separated cells in Matrigel migrate or grow to form spheroids but lack cell-to-cell interaction, which causes difficulty or delay in forming mature spheroi
Externí odkaz:
https://doaj.org/article/36eb0f6b6f644f41a959c4fad515c923
Autor:
Weiwei Zhai, Tony Kiat-Hon Lim, Tong Zhang, Su-Ting Phang, Zenia Tiang, Peiyong Guan, Ming-Hwee Ng, Jia Qi Lim, Fei Yao, Zheng Li, Poh Yong Ng, Jie Yan, Brian K. Goh, Alexander Yaw-Fui Chung, Su-Pin Choo, Chiea Chuen Khor, Wendy Wei-Jia Soon, Ken Wing-Kin Sung, Roger Sik-Yin Foo, Pierce Kah-Hoe Chow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepat
Externí odkaz:
https://doaj.org/article/66747f4fa69e494a8136f9ada8520565