Zobrazeno 1 - 10
of 2 377
pro vyhledávání: '"Pierce K."'
Autor:
Ah-Jung Jeon, Yue-Yang Teo, Karthik Sekar, Shay Lee Chong, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Adaikalavan Ramasamy, Gokce Oguz, Alexander Yaw-Fui Chung, Chung Yip Chan, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H. de Villa, Rouchelle D.dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K. Bonney, Brian K. P. Goh, Greg Tucker-Kellogg, Roger Sik Yin Foo, Pierce K. H. Chow
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is especi
Externí odkaz:
https://doaj.org/article/ac89eae58a5449229b3b4f7dcae89062
Autor:
Marie J. Y. Reolo, Masayuki Otsuka, Justine Jia Wen Seow, Joycelyn Lee, Yun Hua Lee, Phuong H. D. Nguyen, Chun Jye Lim, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Alexander Chung, Brian K. P. Goh, Pierce K. H. Chow, Ramanuj DasGupta, Joe Poh Sheng Yeong, Valerie Chew
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionDespite recent advances in immunotherapy for hepatocellular carcinoma (HCC), the overall modest response rate underscores the need for a better understanding of the tumor microenvironment (TME) of HCC. We have previously shown that CD38 i
Externí odkaz:
https://doaj.org/article/5a4cd342a33d48c3a5625cfed3c9b0ef
Autor:
Jhin Jieh Lim, Lissa Hooi, Yock Young Dan, Glenn K. Bonney, Lei Zhou, Pierce K.-H. Chow, Cheng Ean Chee, Tan Boon Toh, Edward K.-H. Chow
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-21 (2022)
Abstract Background Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective treatment options. While the proteasome inhibitor bortezomib has shown promising preclinical activity in HCC, clinical trials of bortezomib showed
Externí odkaz:
https://doaj.org/article/5f1d1e935a954b05bd21327460ec0650
Autor:
Phuong H. D. Nguyen, Martin Wasser, Chong Teik Tan, Chun Jye Lim, Hannah L. H. Lai, Justine Jia Wen Seow, Ramanuj DasGupta, Cheryl Z. J. Phua, Siming Ma, Jicheng Yang, Sheena D/O Suthen, Wai Leong Tam, Tony K. H. Lim, Joe Yeong, Wei Qiang Leow, Yin Huei Pang, Gwyneth Soon, Tracy Jiezhen Loh, Wei Keat Wan, Chung Yip Chan, Peng Chung Cheow, Han Chong Toh, Alfred Kow, Yock Young Dan, Juinn Huar Kam, Shridhar Iyer, Krishnakumar Madhavan, Alexander Chung, Glenn K. Bonney, Brian K. P. Goh, Naiyang Fu, Victor C. Yu, Weiwei Zhai, Salvatore Albani, Pierce K. H. Chow, Valerie Chew
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In order to design cancer immune therapies, it is important to understand how tumours evade the immune response that is mounted against them. Authors here analyse the distribution and properties of immune cells in hepatocellular carcinoma and describ
Externí odkaz:
https://doaj.org/article/2648047cd2d74e93ad29e2f0557f8fa3
Autor:
Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, Valerie Chew
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Intratumoural heterogeneity is a feature of liver cancer. Here, the authors demonstrate that heterogeneity exists at the immune cell level in liver cancer and show that tumours with high intratumoural immune heterogeneity demonstrated an immune suppr
Externí odkaz:
https://doaj.org/article/04bfa3244f6242d895349149a2c716b4
Autor:
Justine Jia Wen Seow, Rhea Pai, Archita Mishra, Edwin Shepherdson, Tony Kiat Hon Lim, Brian K. P. Goh, Jerry K. Y. Chan, Pierce K. H. Chow, Florent Ginhoux, Ramanuj DasGupta, Ankur Sharma
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
The recent coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2. COVID-19 was first reported in China (December 2019) and is now prevalent across the globe. Entry of severe acute respiratory syndro
Externí odkaz:
https://doaj.org/article/73e8e57f0fe643f5a695f50aaee9ed88
Autor:
Phuong H. D. Nguyen, Siming Ma, Cheryl Z. J. Phua, Neslihan A. Kaya, Hannah L. H. Lai, Chun Jye Lim, Jia Qi Lim, Martin Wasser, Liyun Lai, Wai Leong Tam, Tony K. H. Lim, Wei Keat Wan, Tracy Loh, Wei Qiang Leow, Yin Huei Pang, Chung Yip Chan, Ser Yee Lee, Peng Chung Cheow, Han Chong Toh, Florent Ginhoux, Shridhar Iyer, Alfred W. C. Kow, Yock Young Dan, Alexander Chung, Glen K. Bonney, Brian K. P. Goh, Salvatore Albani, Pierce K. H. Chow, Weiwei Zhai, Valerie Chew
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21556-y.
Externí odkaz:
https://doaj.org/article/08ad460145fc4cdeaa1c1a80cb3d6247
Publikováno v:
Asian Journal of Surgery, Vol 27, Iss 2, Pp 73-79 (2004)
Pancreaticoduodenectomy (PD) is a major procedure with significant mortality and morbidity. In this study, we reviewed our departmental results with PD as subspecialization for hepatopancreaticobiliary surgery developed, and evaluated the effects on
Externí odkaz:
https://doaj.org/article/23c987a5ce874c21a124882b521c8eee
Publikováno v:
International Journal of Hepatology, Vol 2011 (2011)
Hepatocellular carcinoma (HCC) is increasingly being detected at an earlier stage, owing to the screening programs and regular imaging follow-up in high-risk populations. Small HCCs still pose diagnostic challenges on imaging due to decreased sensiti
Externí odkaz:
https://doaj.org/article/a1b74f411e684beba7cdbd9a1c00c15f