Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Piera Quesada"'
Publikováno v:
Biochemical Pharmacology. 85:999-1006
Poly(ADP-ribose)polymerase 1 (PARP-1) inhibitors are thought as breakthrough for cancer treatment in solid tumors such as breast cancer through their effects on PARP's enzymatic activity. Our previous findings showed that the hydrophilic PARP inhibit
Publikováno v:
Biochemical Pharmacology. 75:2356-2363
Poly(ADPR)polymerases’ (PARPs) inhibitors potentiate the cytotoxic effects of chemotherapeutic agents like alkylating compounds and TOPO I poisons, while their action in combination with cisplatin still needs investigation. In fact, one of the earl
Poly (ADP-ribose)polymerase 1 (PARP-1) is involved in cellular processes such as DNA repair and apoptosis. Therefore, PARP-1 inhibitor (PJ34) is considered a potential treatment for p53 proficient breast and ovarian carcinoma cells, when combined wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::8b50f8467e032bf66004a71d23b547c2
http://hdl.handle.net/11588/593710
http://hdl.handle.net/11588/593710
Autor:
Daniela Di Girolamo, Piera Quesada, Viola Calabrò, Annaelena Troiano, Sascha Beneke, Daniela Montariello
Publikováno v:
Biochemical pharmacology. 94(3)
Depending on their genetic background (p53 wt versus p53 null ), carcinoma cells are more or less sensitive to drug-induced cell cycle arrest and/or apoptosis. Among the members of the p53 family, p63 is characterized by two N-terminal isoforms, TAp6
Autor:
Filomena Tramontano, Salvatore Vallefuoco, Silvia Di Meglio, Piera Quesada, A. Ivana Scovassi, Marco Denegri
Publikováno v:
Molecular and Cellular Biochemistry. 248:85-91
Poly(ADP-ribose)polymerase (PARP-1) and poly(ADP-ribose)glycohydrolase (PARG) are responsible for the transient poly(ADP-ribosyl)ation of proteins in eukaryotic cells. This biochemical reaction plays an active role in DNA replication and repair, tran
Rat germinal cells require PARP for repair of DNA damage induced by γ-irradiation and H2O2 treatment
Publikováno v:
European Journal of Cell Biology. 80:222-229
The ability of rat germinal cells to recover from genotoxic stress has been investigated using isolated populations of primary spermatocytes and round spermatids. Using a comet assay at pH 10.0 to assess single strand breakage (SSB) in DNA, it was fo
Publikováno v:
Molecular and Cellular Biochemistry. 205:91-99
The poly(ADP-ribosyl)ation system, associated with different nuclear fractions of rat testis, has been analyzed for both pADPR and pADPR acceptor proteins. The DNase I sensitive and resistant chromatin contain 35% and 40%, respectively, of the total
Autor:
Filomena De Lucia, Piera Quesada, Natale Gentile, M. Rosaria Faraone-Mennella, Benedetta Farina
Publikováno v:
Journal of Cellular Biochemistry. 76:20-29
Rat testis H1 proteins were poly(ADP-ribosyl)ated in vitro. The modifying product, poly(ADP-ribose), was found covalently bound to each histone variant at various extents and exhibited distinct structural features (linear and short, rather than branc
Publikováno v:
Journal of Cellular Biochemistry. 63:334-341
The rat testis chromatin fractions (soluble, S, and insoluble, P) were prepared by mild digestion of nuclei with DNAase I. They appeared to be different in specific biochemical features such as their transcriptional competence and protein patterns, t