Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Pier Vincenzo Plazzi"'
Autor:
Silvia Rivara, Marco Mor, Simone Lorenzi, Alessio Lodola, Pier Vincenzo Plazzi Gilberto Spadoni, Annalida Bedini, Giorgio Tarzia
Publikováno v:
ARKIVOC, Vol 2006, Iss 8, Pp 8-16 (2006)
Externí odkaz:
https://doaj.org/article/51120961f7a4408da6e279f94607f8d5
Autor:
Valentina Zuliani, Maricla Galetti, Caterina Carmi, Mirko Rivara, Federica Vacondio, Pier Giorgio Petronini, Marco Mor, Roberta Alfieri, Marco Fantini, Pier Vincenzo Plazzi, Fabrizio Bordi, Alessio Lodola, Andrea Cavazzoni
Publikováno v:
European Journal of Medicinal Chemistry. 44:3471-3479
Benzylidene hydantoins have been recently reported as a new class of EGFR inhibitors. We describe here a simple and efficient methodology for the parallel solution-phase synthesis of a library of 5-benzylidene hydantoins, which were evaluated for ant
Autor:
Vigilio Ballabeni, Marco Mor, Giovanni Morini, Fabrizio Bordi, Pier Vincenzo Plazzi, Simona Bertoni, Francesca Saccani, Mirko Rivara, Silvia Rivara, Lisa Flammini, Elisabetta Barocelli, Mara Comini
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9911-9924
The combination of antagonism at histamine H 3 receptors and inhibition of acetylcholinesterase has been recently proposed as an approach to devise putative new therapeutic agents for cognitive diseases. The 4,4′-biphenyl fragment has been reported
Autor:
Georg C. Terstappen, Eva Genesio, Elena Pecchioli, Letizia Magnoni, Enrica Diodato, Chiara Ghiron, Pier Vincenzo Plazzi, Giovanni Gaviraghi, Andrea Caricasole, Giuseppe Cocconcelli
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:2043-2052
A parallel synthesis of aryl azoles with neuroprotective activity is described. All compounds obtained were evaluated in an in vitro assay using a NMDA toxicity paradigm showing a neuroprotective activity between 15% and 40%. The potential biological
Autor:
Giuseppe Cocconcelli, Mara Comini, Vigilio Ballabeni, Giovanni Morini, Fabrizio Bordi, Marco Mor, Simona Bertoni, Mirko Rivara, Elisabetta Barocelli, Pier Vincenzo Plazzi, Silvia Rivara, Valentina Zuliani
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:1413-1424
A novel series of non-imidazole H(3)-receptor antagonists was developed, by chemical modification of a potent lead H(3)-antagonist composed by an imidazole ring connected through an alkyl spacer to a 2-aminobenzimidazole moiety (e.g., 2-[[3-[4(5)-imi
Autor:
Silvia Rivara, Elisabetta Barocelli, Marco Mor, Simone Lorenzi, Mirko Rivara, Giovanni Morini, Fabrizio Bordi, Simona Bertoni, Pier Vincenzo Plazzi, Vigilio Ballabeni
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:5647-5657
Histamine H(3) receptor is a G protein-coupled receptor whose activation inhibits the synthesis and release of histamine and other neurotransmitters from nerve endings and is involved in the modulation of different central nervous system functions. H
Autor:
Valentina Zuliani, Federica Vacondio, Simona Bertoni, Mirko Rivara, Silvia Rivara, Pier Vincenzo Plazzi, Elisabetta Barocelli, Francesca Magnanini, Vigilio Ballabeni, Giovanni Morini, Fabrizio Bordi, Claudia Silva
Publikováno v:
Il Farmaco. 58:891-899
It has been recently reported that compounds composed of an imidazole connected through an alkyl spacer to a 2-aminobenzimidazole showed high affinity towards the H(3)-receptor. The guanidine fragment of the 2-aminobenzimidazole is probably involved
Publikováno v:
Il Farmaco. 58:989-993
The 1,2-benzisothiazolin-3-one nucleus is well known in the medicinal chemistry literature for the variety of biological effects exerted by its derivatives. In the present paper, the dependence of the n-octanol/buffer distribution coefficient (D) on
Autor:
Marilou Pannacci, Marco Mor, Franco Fraschini, Andrea Tontini, Gilberto Spadoni, Cesarino Balsamini, Silvia Rivara, Bojidar Stankov, Valeria Lucini, Pier Vincenzo Plazzi, Giorgio Tarzia, Giuseppe Diamantini, Romolo Nonno
Publikováno v:
Journal of Medicinal Chemistry. 44:2900-2912
Several indole analogues of melatonin (MLT) were obtained by moving the MLT side chain from C(3) to C(2) of the indole ring. Binding and in vitro functional assays were performed on cloned human MT1 and MT2 receptors, stably transfected in NIH3T3 cel
Autor:
Silvia Rivara, Pier Vincenzo Plazzi, Giuseppe Diamantini, Bojidar Stankov, Romolo Nonno, Giorgio Tarzia, Barbara Di Giacomo, Annalida Bedini, Gilberto Spadoni, Franco Fraschini, Marilou Pannacci, Marco Mor, Valeria Lucini
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1045-1057
A number of 6-methoxy-1-(2-propionylaminoethyl)indoles, carrying properly selected substituents at the C-2 indole position, were prepared and tested as melatonin receptor ligands. Affinities and intrinsic activities for the human cloned mt 1 and MT 2