Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Pier Paolo, Di Fiore"'
Autor:
Mariadomenica Lupi, Daniele Avanzato, Stefano Confalonieri, Flavia Martino, Rosa Pennisi, Emanuela Pupo, Valentina Audrito, Stefano Freddi, Giovanni Bertalot, Francesca Montani, Bronislava Matoskova, Sara Sigismund, Pier Paolo Di Fiore, Letizia Lanzetti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-14 (2024)
Abstract Metabolic plasticity is a hallmark of cancer, and metabolic alterations represent a promising therapeutic target. Since cellular metabolism is controlled by membrane traffic at multiple levels, we investigated the involvement of TBC1 domain-
Externí odkaz:
https://doaj.org/article/43797c9071184cd3a3653f520685ea16
Autor:
Deborah Mesa, Elisa Barbieri, Andrea Raimondi, Stefano Freddi, Giorgia Miloro, Gorana Jendrisek, Giusi Caldieri, Micaela Quarto, Irene Schiano Lomoriello, Maria Grazia Malabarba, Arianna Bresci, Francesco Manetti, Federico Vernuccio, Hind Abdo, Giorgio Scita, Letizia Lanzetti, Dario Polli, Carlo Tacchetti, Paolo Pinton, Massimo Bonora, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract One open question in the biology of growth factor receptors is how a quantitative input (i.e., ligand concentration) is decoded by the cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endocyt
Externí odkaz:
https://doaj.org/article/1aea93372b324f868e8be4a452c68516
Autor:
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114970- (2024)
Externí odkaz:
https://doaj.org/article/b2ea199df0684449960748dac3c283bb
Autor:
Stefano Confalonieri, Bronislava Matoskova, Rosa Pennisi, Flavia Martino, Agnese De Mario, Giorgia Miloro, Francesca Montani, Luca Rotta, Mahila Esmeralda Ferrari, Laura Gilardi, Francesco Ceci, Chiara Maria Grana, Rosario Rizzuto, Cristina Mammucari, Pier Paolo Di Fiore, Letizia Lanzetti
Publikováno v:
Advanced Science, Vol 11, Iss 28, Pp n/a-n/a (2024)
Abstract Metabolic alterations in cancers can be exploited for diagnostic, prognostic, and therapeutic purposes. This is exemplified by 18F‐fluorodeoxyglucose (FDG)‐positron emission tomography (FDG‐PET), an imaging tool that relies on enhanced
Externí odkaz:
https://doaj.org/article/78823203ee814083a81792ce84af785c
Autor:
Huayi Li, Lorenzo Prever, Myriam Y. Hsu, Wen‐Ting Lo, Jean Piero Margaria, Maria Chiara De Santis, Cristina Zanini, Marco Forni, Francesco Novelli, Salvatore Pece, Pier Paolo Di Fiore, Paolo Ettore Porporato, Miriam Martini, Hassane Belabed, Marc Nazare, Volker Haucke, Federico Gulluni, Emilio Hirsch
Publikováno v:
Advanced Science, Vol 9, Iss 9, Pp n/a-n/a (2022)
Abstract Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths. Here it i
Externí odkaz:
https://doaj.org/article/ee0f506c019b414c91e9c0120c461dd3
Autor:
Irene Schiano Lomoriello, Giovanni Giangreco, Claudia Iavarone, Chiara Tordonato, Giusi Caldieri, Gaetana Serio, Stefano Confalonieri, Stefano Freddi, Fabrizio Bianchi, Stefania Pirroni, Giovanni Bertalot, Giuseppe Viale, Davide Disalvatore, Daniela Tosoni, Maria Grazia Malabarba, Andrea Disanza, Giorgio Scita, Salvatore Pece, Brian K. Pilcher, Manuela Vecchi, Sara Sigismund, Pier Paolo Di Fiore
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a
Externí odkaz:
https://doaj.org/article/13d80ead99db4faeaae47bea7bd4c693
Autor:
Stefano Confalonieri, Ivan Nicola Colaluca, Andrea Basile, Salvatore Pece, Pier Paolo Di Fiore
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 10, Pp 3359-3367 (2019)
MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is
Externí odkaz:
https://doaj.org/article/1f2bbd0240fc4bffbfd02e38154da38b
Autor:
Giulia Marvaso, Delia Ciardo, Giulia Corrao, Sara Gandini, Cristiana Fodor, Dario Zerini, Damaris Patricia Rojas, Matteo Augugliaro, Giuseppina Bonizzi, Salvatore Pece, Federica Cattani, Ketti Mazzocco, Francesco Alessandro Mistretta, Gennaro Musi, Sarah Alessi, Giuseppe Petralia, Gabriella Pravettoni, Ottavio De Cobelli, Pier Paolo Di Fiore, Giuseppe Viale, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background Prostate cancer (PCa) is the second most common cancer among men. New imaging-modalities have increased the diagnosed patients with limited number of metastasis after primary curative therapy, introducing so-called oligometastatic
Externí odkaz:
https://doaj.org/article/f9713b569f414e94b625431c7b7b172b
Autor:
Salvatore Pece, Davide Disalvatore, Daniela Tosoni, Manuela Vecchi, Stefano Confalonieri, Giovanni Bertalot, Giuseppe Viale, Marco Colleoni, Paolo Veronesi, Viviana Galimberti, Pier Paolo Di Fiore
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 352-362 (2019)
Background: Breast cancers show variations in the number and biological aggressiveness of cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity. Thus, prognostic stratification of breast cancers based on cancer st
Externí odkaz:
https://doaj.org/article/b40e7dcb6f9047acbd9737927b3ce038
Autor:
Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, Giorgio Scita
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabi
Externí odkaz:
https://doaj.org/article/391b87a586fe4ec382591d31347a221d