Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters

Autor: Ronen, Sabrina, Costello, Joseph, Viswanath, P, Najac, C, Izquierdo-Garcia, JL, Pankov, A, Hong, C, Eriksson, P, Costello, JF, Pieper, RO, Ronen, SM

Publikováno v: Ronen, Sabrina; Costello, Joseph; Viswanath, P; Najac, C; Izquierdo-Garcia, JL; Pankov, A; et al.(2016). Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1vj489vf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::00740b8aca82a240e109f6b505b12542
http://www.escholarship.org/uc/item/1vj489vf

Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase

Autor: Ronen, Sabrina, Pieper, Russell, Phillips, Joanna, Izquierdo-Garcia, JL, Cai, LM, Chaumeil, MM, Eriksson, P, Robinson, AE, Pieper, RO, Phillips, JJ, Ronen, SM

Publikováno v: Ronen, Sabrina; Pieper, Russell; Phillips, Joanna; Izquierdo-Garcia, JL; Cai, LM; Chaumeil, MM; et al.(2014). Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/2rb2f6jd

Background: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert a-ketoglutarate to 2-hydroxyglutarate, ultimately leadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::9636fcc30cf6621940209412a5140507
http://www.escholarship.org/uc/item/2rb2f6jd

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

Autor: Ronen, Sabrina, Pieper, Russell, Phillips, Joanna, Wiencke, John, Mukherjee, J, Phillips, JJ, Zheng, S, Ronen, SM, Pieper, RO

Publikováno v: Ronen, Sabrina; Pieper, Russell; Phillips, Joanna; Wiencke, John; Mukherjee, J; Phillips, JJ; et al.(2013). Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/18084379

Normal tissues express the M1 isoform of pyruvate kinase (PK) that helps generate and funnel pyruvate into the mitochondria for ATP production. Tumors, in contrast, express the less active PKM2 isoform, which limits pyruvate production and spares gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::aac071a391c748124a2a1150ed300f62
http://www.escholarship.org/uc/item/18084379

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