Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium.

Autor: Herms A; Wellcome Sanger Institute, Hinxton, UK.; Department of Biomedical Sciences, Universitat de Barcelona, Barcelona, Spain.; Lipid Trafficking and Disease Group, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain., Fernandez-Antoran D; Wellcome Sanger Institute, Hinxton, UK.; Wellcome/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.; ARAID Foundation, Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain., Alcolea MP; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Kalogeropoulou A; Wellcome Sanger Institute, Hinxton, UK., Banerjee U; Wellcome Sanger Institute, Hinxton, UK., Piedrafita G; Wellcome Sanger Institute, Hinxton, UK.; Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain.; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Abby E; Wellcome Sanger Institute, Hinxton, UK., Valverde-Lopez JA; Wellcome/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK., Ferreira IS; Wellcome/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK., Caseda I; Department of Biomedical Sciences, Universitat de Barcelona, Barcelona, Spain.; Lipid Trafficking and Disease Group, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain., Bejar MT; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Dentro SC; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.; Artificial Intelligence in Oncology (B450), Deutsches Krebsforschungszentrum, Heidelberg, Germany., Vidal-Notari S; Department of Biochemistry and Molecular Biology, Complutense University of Madrid, Madrid, Spain.; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Ong SH; Wellcome Sanger Institute, Hinxton, UK., Colom B; Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK., Murai K; Wellcome Sanger Institute, Hinxton, UK., King C; Wellcome Sanger Institute, Hinxton, UK., Mahbubani K; Department of Surgery, University of Cambridge, Cambridge, UK.; Collaborative Biorepository for Translational Medicine (CBTM), Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; Collaborative Biorepository for Translational Medicine (CBTM), Cambridge NIHR Biomedical Research Centre, Cambridge, UK., Lowe AR; Institute for Structural and Molecular Biology, University College London, London, UK.; Institute for the Physics of Living Systems, University College London, London, UK.; Department of Physics and Astronomy, University College London, London, UK., Gerstung M; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.; Artificial Intelligence in Oncology (B450), Deutsches Krebsforschungszentrum, Heidelberg, Germany., Jones PH; Wellcome Sanger Institute, Hinxton, UK. pj3@sanger.ac.uk.; Department of Oncology, Hutchison Research Centre, University of Cambridge, Cambridge, UK. pj3@sanger.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2024 Oct; Vol. 56 (10), pp. 2158-2173. Date of Electronic Publication: 2024 Sep 23.

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.

Autor: Abby E; Wellcome Sanger Institute, Hinxton, UK., Dentro SC; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.; Artificial Intelligence in Oncology (B450), Deutsches Krebsforschungszentrum, Heidelberg, Germany., Hall MWJ; Wellcome Sanger Institute, Hinxton, UK.; Department of Oncology, University of Cambridge, Cambridge, UK., Fowler JC; Wellcome Sanger Institute, Hinxton, UK., Ong SH; Wellcome Sanger Institute, Hinxton, UK., Sood R; Wellcome Sanger Institute, Hinxton, UK., Herms A; Wellcome Sanger Institute, Hinxton, UK.; Department of Biomedical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain., Piedrafita G; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Abnizova I; Wellcome Sanger Institute, Hinxton, UK., Siebel CW; Department of Discovery Oncology, Genentech, South San Francisco, CA, USA., Gerstung M; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK.; Artificial Intelligence in Oncology (B450), Deutsches Krebsforschungszentrum, Heidelberg, Germany., Hall BA; Department of Medical Physics and Biomedical Engineering, University College London, London, UK., Jones PH; Wellcome Sanger Institute, Hinxton, UK. pj3@sanger.ac.uk.; Department of Oncology, University of Cambridge, Cambridge, UK. pj3@sanger.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2023 Feb; Vol. 55 (2), pp. 232-245. Date of Electronic Publication: 2023 Jan 19.

Single amino acid-promoted reactions link a non-enzymatic chemical network to the early evolution of enzymatic pentose phosphate pathway

Autor: Piedrafita, G, Varma, S, Castro, C, Messner, C, Szyrwiel, L, Griffin, J, Ralser, M

How metabolic pathways emerged in early evolution remains largely unknown. Recently discovered chemical networks driven by iron and sulfur resemble reaction sequences found within glycolysis, gluconeogenesis, the oxidative and reductive Krebs cycle,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::c463807643b02dc65dfd82d513f38667
http://hdl.handle.net/10044/1/82236

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.

Autor: Colom B; Wellcome Sanger Institute, Hinxton, UK., Alcolea MP; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.; Department of Oncology, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Piedrafita G; Wellcome Sanger Institute, Hinxton, UK.; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Hall MWJ; Wellcome Sanger Institute, Hinxton, UK.; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Wabik A; Wellcome Sanger Institute, Hinxton, UK., Dentro SC; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK., Fowler JC; Wellcome Sanger Institute, Hinxton, UK., Herms A; Wellcome Sanger Institute, Hinxton, UK., King C; Wellcome Sanger Institute, Hinxton, UK., Ong SH; Wellcome Sanger Institute, Hinxton, UK., Sood RK; Wellcome Sanger Institute, Hinxton, UK., Gerstung M; European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge, UK., Martincorena I; Wellcome Sanger Institute, Hinxton, UK., Hall BA; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK. bh418@mrc-cu.cam.ac.uk., Jones PH; Wellcome Sanger Institute, Hinxton, UK. pj3@sanger.ac.uk.; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK. pj3@sanger.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2020 Jun; Vol. 52 (6), pp. 604-614. Date of Electronic Publication: 2020 May 18.

Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure.

Autor: Piedrafita G; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom., Varma SJ; Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany., Castro C; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom., Messner CB; The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, United Kingdom., Szyrwiel L; Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany.; The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, United Kingdom., Griffin JL; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom.; The Rowett Institute, The University of Aberdeen, Aberdeen, United Kingdom., Ralser M; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, United Kingdom.; Department of Biochemistry, Charité Universitätsmedizin Berlin, Berlin, Germany.; The Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, United Kingdom.

Publikováno v: PLoS biology [PLoS Biol] 2021 Dec 03; Vol. 19 (12), pp. e3001468. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).