Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution

Autor: Renuga Devi Rajaram, Romain Dissard, Anna Faivre, Frédérique Ino, Vasiliki Delitsikou, Vincent Jaquet, Thomas Cagarelli, Maja Lindenmeyer, Pidder Jansen-Duerr, Clemens Cohen, Solange Moll, Sophie de Seigneux

Publikováno v: Redox Biology, Vol 26, Iss , Pp - (2019)

Background: NADPH oxidase 4 (NOX4) catalyzes the formation of hydrogen peroxide (H2O2). NOX4 is highly expressed in the kidney, but its role in renal injury is unclear and may depend on its specific tissue localization. Methods: We performed immunost

Externí odkaz: https://doaj.org/article/9382bf16397b4d20bd61be70125fc4ef

The mitochondrial enzyme FAHD1 regulates complex II activity in breast cancer cells and is indispensable for basal BT ‐20 cells in vitro

Autor: Max Holzknecht, Lena Guerrero‐Navarro, Michele Petit, Eva Albertini, Elisabeth Damisch, Anna Simonini, Fernando Schmitt, Walther Parson, Heidelinde Fiegl, Alexander Weiss, Pidder Jansen‐Duerr

Publikováno v: FEBS Letters. 596:2781-2794

The mitochondrial enzyme fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT-20 cells, representing the basal br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76551763a08214253e09d33a63e8e877
https://doi.org/10.1002/1873-3468.14462

Age-Related Lysosomal Dysfunctions

Autor: Pidder Jansen-Duerr, Lena Guerrero-Navarro, Maria Amália Cavinato Nascimento

Publikováno v: Cells. 11:1977

Organismal aging is normally accompanied by an increase in the number of senescent cells, growth-arrested metabolic active cells that affect normal tissue function. These cells present a series of characteristics that have been studied over the last

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fce08564da3bf405a6c6ccd063784c
https://doi.org/10.3390/cells11121977

Identification of the NADPH Oxidase 4 Inhibiting Principle of Lycopus europaeus

Autor: Stefan Schwaiger, Birgit Waltenberger, Hermann Stuppner, Pidder Jansen-Duerr, Silvia Revoltella, Roland Kohl, Giorgia Baraldo, Philipp Kofler, Astrid Huber-Seidel, Julia Moesslacher, Konrad Pagitz

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 23; Issue 3; Pages: 653
Molecules, Vol 23, Iss 3, p 653 (2018)

NADPH oxidase 4 (Nox4) has recently been implicated as driving force in cellular senescence. Thus, there is growing interest to develop Nox4 inhibitors, which might be valuable agents for cosmeceutical applications. Alpine plants represent a valuable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c11db44b8e0266443d33056d734488
https://pubmed.ncbi.nlm.nih.gov/29538284

Human papillomavirus E7 protein detection as a method of triage to colposcopy of HPV positive women, in comparison to genotyping and cytology. Final results of the PIPAVIR study

Autor: Theodoros, Agorastos, Kimon, Chatzistamatiou, Theodoros, Moysiadis, Andreas M, Kaufmann, Alkmini, Skenderi, Irini, Lekka, Isabel, Koch, Erwin, Soutschek, Oliver, Boecher, Vasilis, Kilintzis, Stamatia, Angelidou, Evangelia, Katsiki, Ingke, Hagemann, Eleonora, Boschetti Gruetzmacher, Athena, Tsertanidou, Lefteris, Angelis, Nikolaos, Maglaveras, Pidder, Jansen-Duerr

Publikováno v: International journal of cancer. 141(3)

The objective of the presented cross-sectional-evaluation-screening study is the clinical evaluation of high-risk(hr)HPVE7-protein detection as a triage method to colposcopy for hrHPV-positive women, using a newly developed sandwich-ELISA-assay. Betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::967746cf8c4f85c2d270e4a0e66e96e5
https://pubmed.ncbi.nlm.nih.gov/28470689