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Use of Small-MoleculeCrystal Structures To AddressSolubility in a Novel Series of G Protein Coupled Receptor 119 Agonists:Optimization of a Lead and in Vivo Evaluation.

Autor: Scott, James S., Birch, Alan M., Brocklehurst, Katy J., Broo, Anders, Brown, Hayley S., Butlin, Roger J., Clarke, David S., Davidsson, Öjvind, Ertan, Anne, Goldberg, Kristin, Groombridge, Sam D., Hudson, Julian A., Laber, David, Leach, Andrew G., MacFaul, Philip A., McKerrecher, Darren, Pickup, Adrian, Schofield, Paul, Svensson, Per H., Sörme, Pernilla

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Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.

Autor: Block MH; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom. Michael.Block@Astrazeneca.com, Boyer S, Brailsford W, Brittain DR, Carroll D, Chapman S, Clarke DS, Donald CS, Foote KM, Godfrey L, Ladner A, Marsham PR, Masters DJ, Mee CD, O'Donovan MR, Pease JE, Pickup AG, Rayner JW, Roberts A, Schofield P, Suleman A, Turnbull AV

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