T-cell engagers: model interrogation as a tool to quantify the interplay of relative affinity and target expression on trimer formation.

Autor: Lai M; Clinical Pharmacology and Quantitative Pharmacology, R&D Biopharmaceuticals, AstraZeneca plc, Cambridge, United Kingdom., Pichardo-Almarza C; Clinical Pharmacology and Quantitative Pharmacology, R&D Biopharmaceuticals, AstraZeneca plc, Cambridge, United Kingdom., Verma M; Clinical Pharmacology and Quantitative Pharmacology, R&D Biopharmaceuticals, AstraZeneca Plc, Gaithersburg, MD, United States., Shahinuzzaman M; Clinical Pharmacology and Quantitative Pharmacology, R&D Biopharmaceuticals, AstraZeneca Plc, Gaithersburg, MD, United States., Zhu X; Clinical Pharmacology and Quantitative Pharmacology, R&D Biopharmaceuticals, AstraZeneca Plc, Waltham, MA, United States., Kimko H; Clinical Pharmacology and Quantitative Pharmacology, R&D Biopharmaceuticals, AstraZeneca Plc, Gaithersburg, MD, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Oct 08; Vol. 15, pp. 1470595. Date of Electronic Publication: 2024 Oct 08 (Print Publication: 2024).

Impaired LXRa phosphorylation attenuates progression of fatty liver disease

Autor: Becares, N. (Natalia), Gage, M.C. (Matthew C.), Voisin, M. (Maud), Shrestha, E. (Elina), Martin-Gutierrez, L. (Lucina), Liang, N. (Ning), Louie, R. (Rikah), Pourcet, B. (Benoit), Pello, O.M. (Oscar M.), Luong, T.V. (Tu Vinh), Goñi, S. (Saioa), Pichardo-Almarza, C. (Cesar), Roberg-Larsen, H. (Hanne), Diaz-Zuccarini, V. (Vanessa), Steffensen, K.R. (Knut R. ), O’Brien, A. (Alastair), Garabedian, M.J. (Michael J.), Rombouts, K. (Krista), Treuter, E. (Eckardt), Pineda-Torra, I. (Inés)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Non-alcoholic fatty liver disease (NAFLD) is a very common indication for liver transplantation. How fat-rich diets promote progression from fatty liver to more damaging inflammatory and fibrotic stages is poorly understood. Here, we show that disrup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::20642ce0faddb6eb92fdcc476945eaae
https://hdl.handle.net/10171/63165

Multiscale, patient-specific computational fluid dynamics models predict formation of neointimal hyperplasia in saphenous vein grafts.

Autor: Donadoni F; Department of Mechanical Engineering, Multiscale Cardiovascular Engineering Group, University College London, London, United Kingdom., Pichardo-Almarza C; Department of Mechanical Engineering, Multiscale Cardiovascular Engineering Group, University College London, London, United Kingdom.; Certara Quantitative Systems Pharmacology (QSP), Canterbury, United Kingdom., Homer-Vanniasinkam S; Department of Mechanical Engineering, Multiscale Cardiovascular Engineering Group, University College London, London, United Kingdom.; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, United Kingdom., Dardik A; Yale University School of Medicine, Vascular Biology and Therapeutics, New Haven, Conn.; Department of Surgery, VA Connecticut Healthcare Systems, West Haven, Conn., Díaz-Zuccarini V; Department of Mechanical Engineering, Multiscale Cardiovascular Engineering Group, University College London, London, United Kingdom.; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, United Kingdom.

Publikováno v: Journal of vascular surgery cases and innovative techniques [J Vasc Surg Cases Innov Tech] 2020 Apr 12; Vol. 6 (2), pp. 292-306. Date of Electronic Publication: 2020 Apr 12 (Print Publication: 2020).

S1PR5 对脂多糖诱导小鼠认知行为和炎症反应的 影响及其抗炎机制.

Autor: 任自敬¹, 吴国俊², 王静娴², 张胜广², 周佩洋^1,2 hbxyrzj@hbmu.edu.cn

Publikováno v: Chinese Journal of Pathophysiology. Oct2024, Vol. 40 Issue 10, p1916-1925. 10p.

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.

Autor: Becares N; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Gage MC; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Voisin M; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA., Shrestha E; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA., Martin-Gutierrez L; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Liang N; Karolinska Institute, Centre for Innovative Medicine (CIMED), Department of Biosciences and Nutrition, 14183 Huddinge, Sweden., Louie R; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Pourcet B; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Pello OM; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Luong TV; Department of Cellular Pathology, Royal Free London NHS Foundation Trust, London NW3 2QG, UK., Goñi S; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA., Pichardo-Almarza C; Department of Mechanical Engineering, University College London, London WC1E 7JE, UK., Røberg-Larsen H; Department of Chemistry, University of Oslo, 0371 Oslo, Norway., Diaz-Zuccarini V; Department of Mechanical Engineering, University College London, London WC1E 7JE, UK., Steffensen KR; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, 14186 Huddinge, Sweden., O'Brien A; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK., Garabedian MJ; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA., Rombouts K; Institute for Liver & Digestive Health, University College London, Royal Free, London NW3 2PF, UK., Treuter E; Karolinska Institute, Centre for Innovative Medicine (CIMED), Department of Biosciences and Nutrition, 14183 Huddinge, Sweden., Pineda-Torra I; Centre of Cardiometabolic Medicine, Division of Medicine, University College of London, London WC1 E6JF, UK. Electronic address: i.torra@ucl.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2019 Jan 22; Vol. 26 (4), pp. 984-995.e6.