Výsledky vyhledávání - "Pica-Mattoccia L"

Praziquantel derivatives I: Modification of the aromatic ring

Autor: Ronketti F., Ramana V.A., Chao-Ming X., Pica-Mattoccia L., Cioli D., Todd M.H.

Publikováno v: Bioorganic & medicinal chemistry letters
17 (2007): 4154–4157.
info:cnr-pdr/source/autori:Ronketti F., Ramana V.A., Chao-Ming X., Pica-Mattoccia L., Cioli D. and Todd M.H./titolo:Praziquantel derivatives I: Modification of the aromatic ring./doi:/rivista:Bioorganic & medicinal chemistry letters (Print)/anno:2007/pagina_da:4154/pagina_a:4157/intervallo_pagine:4154–4157/volume:17

Several analogues of the potent anthelmintic praziquantel were prepared with variation in the aromatic ring. The biological activity of these analogues was evaluated and compared against known analogues. Amination of the ring was tolerated while othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::64d18cc1288cf4bac0c8370062f2066c
http://www.cnr.it/prodotto/i/4148

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The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferase

Autor: Pica-Mattoccia L, Guidi A, Carlini D, Cimica V, Cioli D

Publikováno v: 11th International Congress on Parasitology, Glasgow, Scotland, 6-11/08, Glasgow, 2006
info:cnr-pdr/source/autori:Pica-Mattoccia L, Guidi A, Carlini D, Cimica V, Cioli D/congresso_nome:11th International Congress on Parasitology, Glasgow, Scotland, 6-11%2F08/congresso_luogo:Glasgow/congresso_data:2006/anno:2006/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::ac61619006450300621a62de2de5b0c7
http://www.cnr.it/prodotto/i/98685

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Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance

Autor: Doenhoff MJ, Pica-Mattoccia L.

Publikováno v: Expert review of anti-infective therapy 4(2) (2006): 199–210.
info:cnr-pdr/source/autori:Doenhoff MJ, Pica-Mattoccia L./titolo:Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance./doi:/rivista:Expert review of anti-infective therapy/anno:2006/pagina_da:199/pagina_a:210/intervallo_pagine:199–210/volume:4(2)

Praziquantel became available for the treatment of schistosomiasis and other trematode-inflicted diseases in the 1970s. It was revolutionary because it could be administered orally and had very few unwanted side effects. As a result of marked reducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::a59758cbcfceb9ccd855fefb2009869d
http://www.cnr.it/prodotto/i/4133

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Studies on the mechanism of action of praziquantel

Autor: Cioli D, Pica-Mattoccia L, Valle C, Basso A, Troiani AR, Liberti P., Festucci A, Vigorosi F, Guidi A, Maggi AL

Publikováno v: 11th International Congress on Parasitology, Glasgow, Scotland, 6-11/08, Glasgow, 2006
info:cnr-pdr/source/autori:Cioli D, Pica-Mattoccia L, Valle C, Basso A, Troiani AR, Liberti P., Festucci A, Vigorosi F, Guidi A, Maggi AL/congresso_nome:11th International Congress on Parasitology, Glasgow, Scotland, 6-11%2F08/congresso_luogo:Glasgow/congresso_data:2006/anno:2006/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::9168ee3d782ed2ded99f5751dc8e2a91
https://publications.cnr.it/doc/98684

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Current and future antischistosomal drugs

Autor: Cioli D., Pica-Mattoccia L

Publikováno v: info:cnr-pdr/source/autori:Cioli D., Pica-Mattoccia L/titolo:Current and future antischistosomal drugs/editore:/anno:2005

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::f00a75e19b06968a62b9a25252bcd259
https://publications.cnr.it/doc/173059

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Mode of action of the antischistosomal drug oxamniquine

Autor: Pica-Mattoccia L. and Cioli D.

Publikováno v: 2nd COST B22 Congress on Drug Discovery and Development for Parasitic Diseases, Siena, 2005
info:cnr-pdr/source/autori:Pica-Mattoccia L. and Cioli D./congresso_nome:2nd COST B22 Congress on Drug Discovery and Development for Parasitic Diseases/congresso_luogo:Siena/congresso_data:2005/anno:2005/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::057a6d605884d958d5d3f446fdd9fdd2
https://publications.cnr.it/doc/98681

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Effect of praziquantel on the immature stages of Schistosoma haematobium

Autor: Botros S, Pica-Mattoccia L, William S, El-Lakkani N, Cioli D.

Publikováno v: International Journal for Parasitology 35 (2005): 1333–1472.
info:cnr-pdr/source/autori:Botros S, Pica-Mattoccia L, William S, El-Lakkani N, Cioli D./titolo:Effect of praziquantel on the immature stages of Schistosoma haematobium./doi:/rivista:International Journal for Parasitology/anno:2005/pagina_da:1333/pagina_a:1472/intervallo_pagine:1333–1472/volume:35

Schistosoma mansoni is known to be refractory to praziquantel treatment in the pre-patent period of infection. Since Schistosoma haematobium has a much longer pre-patent period (10-12 weeks vs. 5-6 for the former species), we asked the question wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::1f402255654083b45d6a93af16327cce
http://www.cnr.it/prodotto/i/4123

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Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment

Autor: Pica-Mattoccia L, Cioli D.

Publikováno v: International Journal for Parasitology 34 (2004): 527–533.
info:cnr-pdr/source/autori:Pica-Mattoccia L, Cioli D./titolo:Sex-and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment./doi:/rivista:International Journal for Parasitology/anno:2004/pagina_da:527/pagina_a:533/intervallo_pagine:527–533/volume:34

The efficacy of praziquantel against a Puerto Rican strain of Schistosoma mansoni was assessed using both in vivo and in vitro approach. The drug effective dose (50%) in the infected mouse model was about 30 times higher when determined against 28-da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::2acf1327c3d65b8be40bfaf3c54a9245
https://publications.cnr.it/doc/4118

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Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

Autor: Cioli D, Botros SS, Wheatcroft-Francklow K, Mbaye A, Southgate V, Tchuente LA, Pica-Mattoccia L, Troiani AR, El-Din SH, Sabra AN, Albin J, Engels D, Doenhoff MJ.

Publikováno v: International Journal for Parasitology 34 (2004): 979–987.
info:cnr-pdr/source/autori:Cioli D, Botros SS, Wheatcroft-Francklow K, Mbaye A, Southgate V, Tchuente LA, Pica-Mattoccia L, Troiani AR, El-Din SH, Sabra AN, Albin J, Engels D, Doenhoff MJ./titolo:Determination of ED50 values for praziquantel in praziquantel-resistant and-susceptible Schistosoma mansoni isolates./doi:/rivista:International Journal for Parasitology/anno:2004/pagina_da:979/pagina_a:987/intervallo_pagine:979–987/volume:34

The dose of praziquantel required to kill 50% of adult worms in vivo (i.e. the ED50) was estimated for nine different isolates of Schistosoma mansoni in infected mice. Four of the isolates were selected because they had not knowingly been in contact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::fd884bb66714d1eb93191caf681764de
http://www.cnr.it/prodotto/i/4114

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Sequence and level of endogenous expression of calcium channel ß subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel

Autor: Valle C., Troiani A.R., Festucci A., Pica-Mattoccia L., Liberti P., Wolstenholme A., Francklow K., Doenhoff M.J., Cioli D.

Publikováno v: Molecular and biochemical parasitology
130 (2003): 111–115.
info:cnr-pdr/source/autori:Valle C., Troiani A.R., Festucci A., Pica-Mattoccia L., Liberti P., Wolstenholme A., Francklow K., Doenhoff M.J. and Cioli D./titolo:Sequence and level of endogenous expression of calcium channel ß subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel/doi:/rivista:Molecular and biochemical parasitology (Print)/anno:2003/pagina_da:111/pagina_a:115/intervallo_pagine:111–115/volume:130

Kohn et al. [J. Biol. Chem. 276 (2001) 36873] demonstrated that cells expressing the structurally unusual schistosome beta subunit SmCavbeta1 in their voltage-operated calcium channels, exhibit an increased current amplitude in the presence of praziq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::e23a66d2663a3f25ad7f979552fe2496
http://www.cnr.it/prodotto/i/4109

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