Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Pia Steen Petersen"'
Autor:
Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Nils Wierup, Frank Sundler, Birgitte Holst, Thue W. Schwartz
Publikováno v:
International Journal of Endocrinology, Vol 2011 (2011)
Mice deficient in the zinc-sensor GPR39, which has been demonstrated to protect cells against endoplasmatic stress and cell death in vitro, display moderate glucose intolerance and impaired glucose-induced insulin secretion. Here, we use the Tet-On s
Externí odkaz:
https://doaj.org/article/d147df460811438080b301bd70c244b7
Autor:
Anja Bengtsson, Kristoffer Rigbolt, Denise Oro, Helene Ægidius, Pia Steen Petersen, Niels Vrang, Jacob Jelsing, Lisbeth N Fink, Sanne Veidal
Publikováno v:
Journal of Hepatology. 73:S401
Autor:
Tom-Marten Kilian, Annette G. Beck-Sickinger, Birgitte Holst, Thue W. Schwartz, Constance Chollet, Jacek Mokrosinski, Thomas M. Frimurer, Sylvia Els, Enrico Schild, Pia Steen Petersen
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry; Vol 55
Journal of Medicinal Chemistry; Vol 55
The ghrelin receptor displays a high constitutive activity suggested to be involved in the regulation of appetite and food intake. Here, we have created peptides with small changes in the core binding motif -wFw- of the hexapeptide KwFwLL-NH(2) that
Autor:
Thue W. Schwartz, Andreas N. Madsen, Birgitte Holst, Lars Bo Nielsen, Maria Rasmussen, Rune E. Kuhre, Chunyu Jin, Pia Steen Petersen, Kristoffer L. Egerod
Publikováno v:
The FASEB Journal. 25:3803-3814
GPR39, a constitutively active 7TM receptor important for glucose-induced insulin secretion and maturation of pancreatic β-cell function, is up-regulated in adipose tissue on abstinence from food and chemically induced diabetes. In the present study
Autor:
Manja Lang, Birgitte Holst, Nicholas D. Holliday, Annette G. Beck-Sickinger, Thue W. Schwartz, Andreas N. Madsen, Anders Bach, Thomas M. Frimurer, Bjørn Sivertsen, Sylvia Els, Maja S. Engelstoft, Pia Steen Petersen
Publikováno v:
Journal of Biological Chemistry; Vol 286
Based on the conformationally constrained D-Trp-Phe-D-Trp (wFw) core of the prototype inverse agonist [D-Arg(1),D-Phe(5),D-Trp(7,9),Leu(11)]substance P, a series of novel, small, peptide-mimetic agonists for the ghrelin receptor were generated. By us
Autor:
Anders Bach, Birgitte Holst, Pia Steen Petersen, Maja S. Engelstoft, Rie Nygaard, Thue W. Schwartz, Thomas M. Frimurer, Louise Valentin-Hansen
Publikováno v:
Journal of Biological Chemistry; Vol 285
The conserved tryptophan in position 13 of TM-VI (Trp-VI:13 or Trp-6.48) of the CWXP motif located at the bottom of the main ligand-binding pocket in TM-VI is believed to function as a rotameric microswitch in the activation process of seven-transmem
Autor:
Birgitte Holst, Kristoffer L. Egerod, Manja Lang, David P.D. Woldbye, Annette G. Beck-Sickinger, Maria Rasmussen, Andreas N. Madsen, Pia Steen Petersen, Chunyu Jin
Publikováno v:
Endocrinology. 150(11)
The receptor for the orexigenic peptide, ghrelin, is one of the most constitutively active 7TM receptors known, as demonstrated under in vitro conditions. Change in expression of a constitutively active receptor is associated with change in signaling
Autor:
A. M. Ejernaes Sprinkel, Kristoffer L. Egerod, Jacob Hald, Frank Sundler, Birgitte Holst, Thue W. Schwartz, Ole D. Madsen, Joachim Størling, Mette V. Østergaard, Pia Steen Petersen, Nils Wierup, Jens J. Holst, Chunyu Jin, Peter Thams, Cathrine Ørskov, Thomas Mandrup-Poulsen
Publikováno v:
Endocrinology. 150(6)
G protein-coupled receptor (GPR)-39 is a seven-transmembrane receptor expressed mainly in endocrine and metabolic tissues that acts as a Zn(++) sensor signaling mainly through the G(q) and G(12/13) pathways. The expression of GPR39 is regulated by he
Autor:
Jan Mulder, Pia Steen Petersen, Tomas Hökfelt, Birgitte Holst, Kristoffer L. Egerod, Thue W. Schwartz, Jacob B. Hansen
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 21(7)
G protein-coupled receptor 39 (GPR39) is a constitutively active, orphan member of the ghrelin receptor family that is activated by zinc ions. GPR39 is here described to be expressed in a full-length, biologically active seven-transmembrane form, GPR
Autor:
Pia Steen Petersen, Anne Tybjærg-Hansen, Lisbeth Enggaard Larsen, M Appleyard, Henrik Birgens, Poul Schlichting, Torben Saermark, Thomas Mandrup-Poulsen, Merete Frandsen, Christina Ellervik, Børge G. Nordestgaard
Publikováno v:
Lancet (London, England). 358(9291)
Summary Background Although genotyping studies suggest that hereditary haemochromatosis is one of the most common genetic disorders in white people, it is still thought of as an uncommon disease. Our aim was to test the hypothesis that hereditary hae