Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pia Skantze"'
Autor:
Marco Maugeri, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, Manli Na, Mikko Hölttä, Pia Skantze, Svante Johansson, Martina Sundqvist, Johnny Lindquist, Tomas Kjellman, Inga-Lill Mårtensson, Tao Jin, Per Sunnerhagen, Sofia Östman, Lennart Lindfors, Hadi Valadi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Lipid nanoparticles (LNPs) are potential platforms for RNA-based therapeutics, but the fate of LNP-RNAs upon internalization into the cell is unclear. Here, the authors show that LNP-mRNAs and ionizable lipids escape the endosomes and are re-released
Externí odkaz:
https://doaj.org/article/8b2d6ac14e79424d88fcb0a687a8a932
Autor:
Kjetil Elvevold, Bård Smedsrød, Erik Michaëlsson, Lena Svensson, Lars Löfgren, Lennart Lindfors, Pär Nordell, Kalle Sigfridsson, Britt Fuglesteg, Urban Skantze, Pia Skantze
Publikováno v:
International Journal of Pharmaceutics. 524:248-256
A stabilized high drug load intravenous formulation could allow compounds with less optimal pharmacokinetic profiles to be developed. Polyethylene glycol (PEG)-ylation is a frequently used strategy for particle delivery systems to avoid the liver, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c70099aaf49af78bab667f236eb5cd
https://doi.org/10.1016/j.ijpharm.2017.03.062
https://doi.org/10.1016/j.ijpharm.2017.03.062
Autor:
Svante Johansson, Bård Smedsrød, Urban Skantze, Lennart Lindfors, Pia Skantze, Kjetil Elvevold, Britt Fuglesteg, Iain Grant, Kalle Sigfridsson
Publikováno v:
International Journal of Pharmaceutics. 518:29-40
In the present work, milled nanocrystals of a poorly soluble compound using different stabilizers were prepared and characterized. The aim of the study was to evaluate a fundamental set of properties of the formulations prior to i.v. injection of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04334b6d043fa74e0445f51f9f63403
https://doi.org/10.1016/j.ijpharm.2016.12.035
https://doi.org/10.1016/j.ijpharm.2016.12.035
Autor:
Svante Johansson, Lennart Lindfors, Per Sunnerhagen, Alexandros Papadimitriou, Tomas Kjellman, Muhammad Nawaz, Johnny Lindquist, Annelie Angerfors, Tao Jin, Inga-Lill Mårtensson, Martina Sundqvist, Sofia Östman, Mikko Hölttä, Pia Skantze, Hadi Valadi, Manli Na, Marco Maugeri, Alessandro Camponeschi
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
RNA-based therapeutics hold great promise for treating diseases and lipid nanoparticles (LNPs) represent the most advanced platform for RNA delivery. However, the fate of the LNP-mRNA after endosome-engulfing and escape from the autophagy-lysosomal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d98e291d28789b318606c4f404ec382
http://europepmc.org/articles/PMC6760118
http://europepmc.org/articles/PMC6760118
Publikováno v:
Early Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f6465fa0dba4ef2ddee8cbdbacfb53
https://doi.org/10.1002/9783527801756.ch13
https://doi.org/10.1002/9783527801756.ch13
Publikováno v:
Journal of Pharmaceutical Sciences. 100:2194-2202
Drug solubility is an important issue when progressing investigational compounds into clinical candidates. The present paper describes the development and characterization of a nanosuspension that was formulated to overcome problems with poor water s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b391610698e24adc0e2610ce15bd98c
https://doi.org/10.1002/jps.22440
https://doi.org/10.1002/jps.22440
Publikováno v:
Langmuir. 23:9866-9874
In the present paper, we have studied particle dissolution and crystal growth of the poorly water soluble drug felodipine, using fluorescence as a probe for the amount of crystalline material. Dissolution kinetics is essentially diffusion-controlled,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54406a6d5798c7c37bc5252329fb7cb8
https://doi.org/10.1021/la700811b
https://doi.org/10.1021/la700811b
Autor:
Mikael Rasmusson, Pia Skantze, Urban Skantze, Ulf Olsson, Zackrisson Anna Elisabeth, Lennart Lindfors
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 22(3)
Amorphous drug nanosuspensions are prone to particle growth due to Ostwald ripening. By incorporating a second component of extremely low aqueous solubility, Ostwald ripening can be inhibited. These studies indicate that to inhibit ripening, the drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ede96a03bfc9493ee3b1a0d595d727
https://pubmed.ncbi.nlm.nih.gov/16430247
https://pubmed.ncbi.nlm.nih.gov/16430247