Role of B-cells in Mycosis Fungoides

Autor: Pia Rude Nielsen, Jens Ole Eriksen, Mia Dahl Sørensen, Ulrike Wehkamp, Lise M. Lindahl, Michael Bzorek, Lars Iversen, Anders Woetman, Niels Ødum, Thomas Litman, Lise Mette Rahbek Gjerdrum

Publikováno v: Acta Dermato-Venereologica, Vol 101, Iss 3, p adv00413 (2021)

Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. The inflammatory micro­environment in mycosis fungoides is complex. There is accumulating evidence that the neoplastic T-cells take control of the microenvironment and thereby p

Externí odkaz: https://doaj.org/article/aac715c77a0847a9a901f18b8ecf915b

Concomitant Inhibition of FASN and SREBP Provides a Promising Therapy for CTCL

Autor: Cheng Chi, Lisa Harth, Marina Ramírez Galera, Marina Passos Torrealba, Chella Krishna Vadivel, Carsten Geisler, Charlotte Menné Bonefeld, Pia Rude Nielsen, Michael Bzorek, Jürgen C. Becker, Lise Mette Rahbek Gjerdrum, Niels Ødum, Anders Woetmann

Publikováno v: Chi, C, Harth, L, Galera, M R, Torrealba, M P, Vadivel, C K, Geisler, C, Bonefeld, C M, Nielsen, P R, Bzorek, M, Becker, J C, Gjerdrum, L M R, Ødum, N & Woetmann, A 2022, ' Concomitant Inhibition of FASN and SREBP Provides a Promising Therapy for CTCL ', Cancers, vol. 14, no. 18, 4491 . https://doi.org/10.3390/cancers14184491
Cancers; Volume 14; Issue 18; Pages: 4491

Cutaneous T cell lymphoma (CTCL) is a group of non-Hodgkin’s primary cutaneous T cell lymphomas, with Mycosis Fungoides and Sézary syndrome (SS) being the two most common subtypes. Fatty acid synthase (FASN) is a crucial enzyme that catalyses the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5766bbcd5243e2d0c96d1f5903046f
https://pubmed.ncbi.nlm.nih.gov/36139650

A Novel Eight Octapeptide Repeat Insertion in PRNP Causing Prion Disease in a Danish Family

Autor: Linea Melchior, Peter Høgh, Piero Parchi, David Scheie, Eva Løbner Lund, Helle Broholm, Aušrinė Areškevičiūtė, Anna Bartoletti-Stella, Sabina Capellari, Pia Rude Nielsen

Publikováno v: Journal of Neuropathology & Experimental Neurology. 78:595-604

Octapeptide repeat insertions (OPRI) found in the prion protein gene (PRNP) constitute a subgroup of pathogenic mutations linked to inherited prion diseases, a hallmark of which is a misfolded prion protein. The number of repeats in OPRI has been ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1c09f2ffff374194cf0d8b0b5d6cd8
https://doi.org/10.1093/jnen/nlz037

Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt–Jakob Disease Patients

Autor: Linea Melchior, Helle Broholm, Alison Green, Eva Løbner Lund, Colin Smith, Thomas Litman, Aušrinė Areškevičiūtė, Jens Eriksen, Pia Rude Nielsen

Publikováno v: Areškevičiūtė, A, Litman, T, Broholm, H, Melchior, L C, Nielsen, P R, Green, A, Eriksen, J O, Smith, C & Lund, E L 2020, ' Regional Differences in Neuroinflammation-Associated Gene Expression in the Brain of Sporadic Creutzfeldt–Jakob Disease Patients ', International Journal of Molecular Sciences, vol. 22, no. 1, pp. 140 . https://doi.org/10.3390/ijms22010140
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 140, p 140 (2021)
Volume 22
Issue 1
Areškevičiūtė, A, Litman, T, Broholm, H, Melchior, L C, Nielsen, P R, Green, A, Eriksen, J O, Smith, C & Lund, E L 2021, ' Regional differences in neuroinflammation-associated gene expression in the brain of sporadic creutzfeldt–jakob disease patients ', International Journal of Molecular Sciences, vol. 22, no. 1, 140, pp. 1-17 . https://doi.org/10.3390/ijms22010140

Neuroinflammation is an essential part of neurodegeneration. Yet, the current understanding of neuroinflammation-associated molecular events in distinct brain regions of prion disease patients is insufficient to lay the ground for effective treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db85918937732ecd84ca18396130fd87
https://hdl.handle.net/20.500.11820/fd60ee3a-1de0-418b-89f1-43914121b420

Clinical and histological characteristics of mycosis fungoides and sézary syndrome:A retrospective, single-centre study of 43 patients from eastern Denmark

Autor: Jens Eriksen, Robert Gniadecki, Hanne Fogh, Lise M. Lindahl, Michael Bzorek, Niels Ødum, Ulrike Wehkamp, Susanne Fabricius, Pia Rude Nielsen, Lise Mette Rahbek Gjerdrum

Publikováno v: Nielsen, P R, Eriksen, J O, Wehkamp, U, Lindahl, L M, Gniadecki, R, Fogh, H, Fabricius, S, Bzorek, M, Ødum, N & Gjerdrum, L M R 2019, ' Clinical and histological characteristics of mycosis fungoides and sézary syndrome : A retrospective, single-centre study of 43 patients from eastern Denmark ', Acta Dermato-Venereologica, vol. 99, no. 13, pp. 1231-1236 . https://doi.org/10.2340/00015555-3351
Nielsen, P R, Eriksen, J O, Wehkamp, U, Lindahl, L M, Gniadecki, R, Fogh, H, Fabricius, S, Bzorek, M, Ødum, N & Gjerdrum, L M 2019, ' Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome : A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark ', Acta Dermato-Venereologica, vol. 99, no. 13, pp. 1231-1236 . https://doi.org/10.2340/00015555-3351
Acta Dermato-Venereologica, Vol 99, Iss 13, Pp 1231-1236 (2019)

Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathologicadata for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Den

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49a21ebfe92e267a77f8ec9e51cac860
https://curis.ku.dk/ws/files/237100561/5616.pdf