Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Pia Rivetti di Val Cervo"'
Publikováno v:
Nature Reviews. Neurology
Human induced pluripotent stem cells (hiPSCs) were first generated in 2007, but the full translational potential of this valuable tool has yet to be realized. The potential applications of hiPSCs are especially relevant to neurology, as brain cells f
Autor:
Saiful Islam, Sten Linnarsson, Daniel Gyllborg, Carlos Villaescusa, Enrique M. Toledo, Ernest Arenas, Pia Rivetti di Val Cervo, Gioele La Manno
Midbrain dopaminergic (mDA) neurons degenerate in Parkinson’s disease and are one of the main targets for cell replacement therapies. However, a comprehensive view of the signals and cell types contributing to mDA neurogenesis is not yet available.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef3152813728e2b6d1b36b470f21f6c
Autor:
Michael Landreh, Roger A. Barker, Rocio Laguna-Goya, Peter Lönnerberg, Simon R.W. Stott, Karol Kaiser, Enrique M. Toledo, Saiful Islam, Ernest Arenas, Tomas Bergman, Sten Linnarsson, Shanzheng Yang, Licia Selleri, Pia Rivetti di Val Cervo, J. Carlos Villaescusa, Anna Falk, Daniel Gyllborg, Bingsi Li
Publikováno v:
The EMBO journal, vol 35, iss 18
Villaescusa, JC; Li, B; Toledo, EM; Cervo, PRDV; Yang, S; Stott, SRW; et al.(2016). A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO JOURNAL, 35(18), 1963-1978. doi: 10.15252/embj.201593725. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/92d7s9hr
Europe PubMed Central
Villaescusa, JC; Li, B; Toledo, EM; Cervo, PRDV; Yang, S; Stott, SRW; et al.(2016). A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO JOURNAL, 35(18), 1963-1978. doi: 10.15252/embj.201593725. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/92d7s9hr
Europe PubMed Central
Pre-B-cell leukemia homeobox (PBX) transcription factors are known to regulate organogenesis, but their molecular targets and function in midbrain dopaminergic neurons (mDAn) as well as their role in neurodegenerative diseases are unknown. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69de6e6abcc9000bdadad12d4718dab4
https://escholarship.org/uc/item/92d7s9hr
https://escholarship.org/uc/item/92d7s9hr
Autor:
Débora Masini, Giada Spigolon, Enrique M. Toledo, Gilberto Fisone, Marius Wernig, Pia Rivetti di Val Cervo, Roman A. Romanov, Gioele La Manno, Elisa Martín-Montañez, Sten Linnarsson, Michael Feyder, Tibor Harkany, Sara Padrell Sánchez, Yi Han Ng, Ernest Arenas, Christian Pifl
Publikováno v:
Nature Biotechnology
Cell replacement therapies for neurodegenerative disease have focused on transplantation of the cell types affected by the pathological process. Here we describe an alternative strategy for Parkinson's disease in which dopamine neurons are generated
Autor:
Gennaro Melino, Simona Rossi, Elena Dellambra, Eleonora Candi, Christian Mahé, George A. Calin, Huiqing Zhou, Mara Mancini, Anna Maria Lena, Pia Rivetti di Val Cervo, Gaelle Saintigny, Milena S. Nicoloso, Teresa Odorisio
Publikováno v:
Proceedings of the National Academy of Sciences USA, 109, 1133-1138
Proceedings of the National Academy of Sciences USA, 109, 4, pp. 1133-1138
Proceedings of the National Academy of Sciences USA, 109, 4, pp. 1133-1138
We investigated the expression of microRNAs (miRNAs) associated with replicative senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in senescence was identified by genome-wide miRNA profiling, and their change in expression wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aace75cf76fec00960ccdb9cbc4e230a
http://hdl.handle.net/2108/78136
http://hdl.handle.net/2108/78136
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets
Autor:
Eleonora Candi, Frank McKeon, Berna S. Sayan, Tak W. Mak, Gerry Melino, Richard Killick, Massimiliano Agostini, Paola Tucci, Pierluigi Nicotera, Richard A. Knight, Pia Rivetti di Val Cervo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 108(52), 21093-21098 (2011). doi:10.1073/pnas.1112061109
The p53-family member TAp73 is a transcription factor that plays a key role in many biological processes. Here, we show that p73 drives the expression of microRNA (miR)-34a, but not miR-34b and -c, by acting on specific binding sites on the miR-34a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f0afdcb5dc219d23974814f58b647b
http://hdl.handle.net/2108/53946
http://hdl.handle.net/2108/53946
Autor:
Massimiliano Agostini, Sergio Bernardini, Martin J. S. Dyer, Eleonora Candi, Gerry Cohen, Paola Tucci, Pia Rivetti di Val Cervo, Aneela Majid, Gerry Melino, Pierluigi Nicotera, Maria Anna Lena
Chronic lymphocytic leukemia (CLL) is characterized by cells that exhibit dysfunctional apoptosis. Here, we show that deacetylase inhibition led to the E2F1- and myc-mediated transcriptional activation of the microRNA miR106b in primary CLL cells. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41970113dbd602e684539b7b180ea3da
http://hdl.handle.net/2108/16100
http://hdl.handle.net/2108/16100
Autor:
Margherita Verani, Olaf Riess, Alberto Bresciani, Paola Martufi, Gerardo Biella, Paul Saftig, Elena Vezzoli, Francesca Talpo, Giulio Sancini, Ottavia Cecchetti, Paola Conforti, Andrea Falqui, Pia Rivetti di Val Cervo, Elisa Sogne, Lisa Seipold, Hoa Nguyen, Chiara Zuccato, Dario Besusso, Elena Cattaneo, Lara Petricca, Ilaria Caron, Andrea Caricasole, Elisa Battaglia
Publikováno v:
Journal of Clinical Investigation
A disintegrine and metalloproteinase 10 (ADAM10) is implicated in synaptic function through its interaction with postsynaptic receptors and adhesion molecules. Here, we report that levels of active ADAM10 are increased in Huntington's disease (HD) mo