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Autor:
Jakob Felding, Morten Dahl Sørensen, Karen Margrethe Engell, Pontus Hegardt, Jens Christian Højland Larsen, Anne Marie Vinggaard, Anders Søhoel, Pia Refer, Simon Feldbaek Nielsen, Christina Andersson, Lotte G. Ladefoged, Tina Dahlerup Poulsen, Thorsten Thormann
Publikováno v:
Journal of Medicinal Chemistry. 57:5893-5903
Development of orally available phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory drugs has been going on for decades. However, only roflumilast has received FDA approval. One key challenge has been the low therapeutic window observed in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba6a2198c41f3791da043fbf961f273
https://doi.org/10.1021/jm500378a
https://doi.org/10.1021/jm500378a
