Výsledky vyhledávání - "Pia R, Lundegaard"

Akademický článek

Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics.

Autor: Iris A Unterweger, Julie Klepstad, Edouard Hannezo, Pia R Lundegaard, Ala Trusina, Elke A Ober

Publikováno v: PLoS Biology, Vol 21, Iss 10, p e3002315 (2023)

To meet the physiological demands of the body, organs need to establish a functional tissue architecture and adequate size as the embryo develops to adulthood. In the liver, uni- and bipotent progenitor differentiation into hepatocytes and biliary ep

Externí odkaz: https://doaj.org/article/f3dfa61ca94e4f20962d72c9cdc2a81c

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Akademický článek

Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

Autor: Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Nicholette D. Palmer, Yii-Der Chen, Seung H. Choi, Steven A. Lubitz, Patrick T. Ellinor, Kathleen C. Barnes, Michelle Daya, Nicholas Rafaels, Scott T. Weiss, Jessica Lasky-Su, Russell P. Tracy, Ramachandran S. Vasan, L. Adrienne Cupples, Rasika A. Mathias, Lisa R. Yanek, Lewis C. Becker, Patricia A. Peyser, Lawrence F. Bielak, Jennifer A. Smith, Stella Aslibekyan, Bertha A. Hidalgo, Donna K. Arnett, Marguerite R. Irvin, James G. Wilson, Solomon K. Musani, Adolfo Correa, Stephen S. Rich, Xiuqing Guo, Jerome I. Rotter, Barbara A. Konkle, Jill M. Johnsen, Allison E. Ashley-Koch, Marilyn J. Telen, Vivien A. Sheehan, John Blangero, Joanne E. Curran, Juan M. Peralta, Courtney Montgomery, Wayne H-H Sheu, Ren-Hua Chung, Karen Schwander, Seyed M. Nouraie, Victor R. Gordeuk, Yingze Zhang, Charles Kooperberg, Alexander P. Reiner, Rebecca D. Jackson, Eugene R. Bleecker, Deborah A. Meyers, Xingnan Li, Sayantan Das, Ketian Yu, Jonathon LeFaive, Albert Smith, Tom Blackwell, Daniel Taliun, Sebastian Zollner, Lukas Forer, Sebastian Schoenherr, Christian Fuchsberger, Anita Pandit, Matthew Zawistowski, Sachin Kheterpal, Chad M. Brummett, Pradeep Natarajan, David Schlessinger, Seunggeun Lee, Hyun Min Kang, Francesco Cucca, Oddgeir L. Holmen, Bjørn O. Åsvold, Michael Boehnke, Sekar Kathiresan, Goncalo R. Abecasis, Y. Eugene Chen, Cristen J. Willer, Kristian Hveem

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits w

Externí odkaz: https://doaj.org/article/2eecf9230b454b46b95b45b0f20ddd2e

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Akademický článek

Quantitative proteome comparison of human hearts with those of model organisms.

Autor: Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby

Publikováno v: PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)

Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card

Externí odkaz: https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c

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Akademický článek

Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation

Autor: Gustav Ahlberg, Lena Refsgaard, Pia R. Lundegaard, Laura Andreasen, Mattis F. Ranthe, Nora Linscheid, Jonas B. Nielsen, Mads Melbye, Stig Haunsø, Ahmad Sajadieh, Lu Camp, Søren-Peter Olesen, Simon Rasmussen, Alicia Lundby, Patrick T. Ellinor, Anders G. Holst, Jesper H. Svendsen, Morten S. Olesen

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Common genetic variants in structural proteins contribute to risk of atrial fibrillation (AF). Here, using whole-exome sequencing, the authors identify rare truncating variants in TTN that associate with familial and early-onset AF and show defects i

Externí odkaz: https://doaj.org/article/32b75a989a0d494f99383ba50d107a85

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Akademický článek

Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Autor: Anna M Sokol, Barbara Uszczynska-Ratajczak, Michelle M Collins, Michal Bazala, Ulrike Topf, Pia R Lundegaard, Sreedevi Sugunan, Stefan Guenther, Carsten Kuenne, Johannes Graumann, Sherine S L Chan, Didier Y R Stainier, Agnieszka Chacinska

Publikováno v: PLoS Genetics, Vol 15, Iss 1, p e1007972 (2019)

[This corrects the article DOI: 10.1371/journal.pgen.1007743.].

Externí odkaz: https://doaj.org/article/7b73b7d754a74cebb5b5c4b59e3956f3

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LiverZap: A chemoptogenetic tool for global and locally restricted hepatocyte ablation to study cellular behaviours in liver regeneration

Autor: Elizabeth M. G. Ambrosio, Charlotte S. L. Bailey, Iris A. Unterweger, Jens B. Christensen, Marcel P. Bruchez, Pia R. Lundegaard, Elke A. Ober

The liver restores its mass and architecture after injury. Yet, investigating morphogenetic cell behaviours and signals that repair tissue architecture at high spatiotemporal resolution remains challenging. We developed LiverZap, a tuneable chemoptog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06ac4bfece0b83efd8e0ca3d06408ee4
https://doi.org/10.1101/2023.03.13.531762

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Akademický článek

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish.

Publikováno v: PLoS Genetics, Vol 14, Iss 11, p e1007743 (2018)

Development and function of tissues and organs are powered by the activity of mitochondria. In humans, inherited genetic mutations that lead to progressive mitochondrial pathology often manifest during infancy and can lead to death, reflecting the in

Externí odkaz: https://doaj.org/article/23383a47843e48fcb904a69659560535

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Genetic Variants Close to

Publikováno v: Circulation research. 131(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a80d45fc270fdedb56e98afc696b369
https://pubmed.ncbi.nlm.nih.gov/36205134

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Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish

Autor: Pia R. Lundegaard, Janett Piesker, Clemens Mueller, Giulia L. M. Boezio, Didier Y.R. Stainier, Anabela Bensimon-Brito, Arno Nauerth, Christian S. M. Helker, Radhan Ramadass, Srinath Ramkumar, Astrid Wietelmann, João Cardeira-da-Silva

Publikováno v: Bensimon-Brito, A, Boezio, G L M, Cardeira-da-Silva, J, Wietelmann, A, Ramkumar, S, Lundegaard, P R, Helker, C S M, Ramadass, R, Piesker, J, Nauerth, A, Mueller, C & Stainier, D Y R 2022, ' Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish ', Cardiovascular Research, vol. 118, no. 12, pp. 2665–2687 . https://doi.org/10.1093/cvr/cvab310

Aims Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The zebrafish is a well-estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777608fd9b571bf7a88b7573b49754c3
https://curis.ku.dk/ws/files/358644811/cvab310.pdf

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