Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Pia P. Yachi"'
Publikováno v:
EMBO reports. 12:1251-1256
Bimolecular fluorescence complementation was used to engineer CD8 molecules so that CD8αα and CD8αβ dimers can be independently visualized on the surface of a T cell during antigen recognition. Using this approach, we show that CD8αα is recruit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00487d848c7a752234eaa2fc9204e76d
https://doi.org/10.1038/embor.2011.209
https://doi.org/10.1038/embor.2011.209
Publikováno v:
The Journal of Experimental Medicine
T cells are extremely sensitive in their ability to find minute amounts of antigenic peptide in the midst of many endogenous peptides presented on an antigen-presenting cell. The role of endogenous peptides in the recognition of foreign peptide and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a839f2ea4ba19983225be8600cab78
https://doi.org/10.1084/jem.20062610
https://doi.org/10.1084/jem.20062610
Autor:
Wendy L. Havran, Pia P. Yachi, Elaine Fuchs, Richard Boismenu, Nicole Chen, Karen Ugarte, Julie M. Jameson
Publikováno v:
Science. 296:747-749
γδ T cell receptor–bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dfdefc2ab65c8370f4c793ff1d036e6
https://doi.org/10.1126/science.1069639
https://doi.org/10.1126/science.1069639
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783642038570
The co-receptors CD4 and CD8 are important in the activation of T cells, primarily because of their ability to interact with the proteins of the MHC, enhancing recognition of the MHC–peptide complex by the T cell receptor (TCR). An antigen-presenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0226188b0f54b43bf6a34e1fe5df8e
https://europepmc.org/articles/PMC5788015/
https://europepmc.org/articles/PMC5788015/
Autor:
Jean Pierre Clamme, Guo Fu, Nathalie Niederberger, Tomasz Zal, Vasily Rybakin, Ed Palmer, Jeanette Ampudia, Carina Lotz, Pia P. Yachi, Nicholas R. J. Gascoigne, Michel Mallaun
Publikováno v:
Current Topics in Microbiology and Immunology ISBN: 9783540938620
The use of appropriate fluorescent proteins has allowed the use of FRET microscopy for investigation of intermolecular interactions in living cells. This method has the advantage of both being dynamic and of working at the subcellular level, so that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c1c2370d628039f6690001ac41704f
https://doi.org/10.1007/978-3-540-93864-4_2
https://doi.org/10.1007/978-3-540-93864-4_2
Autor:
E. Zambricki, Tomasz Zal, Dianne B. McKay, Pia P. Yachi, Jonathan Sprent, Nicholas R. J. Gascoigne, Alana A. Shigeoka
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 6(11)
T cells contact allogeneic antigen presenting cells (APCs) and assemble, at their contact interface, a molecular platform called the immunological synapse. Synapse-based molecules provide directional signals for the T cell--either positive signals, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f307e0d687e1b450f8b7344ada50e2
https://pubmed.ncbi.nlm.nih.gov/16952297
https://pubmed.ncbi.nlm.nih.gov/16952297
Publikováno v:
Nature immunology. 6(8)
It is unclear if the interaction between CD8 and the T cell receptor (TCR)-CD3 complex is constitutive or antigen induced. Here, fluorescence resonance energy transfer microscopy between fluorescent chimeras of CD3zeta and CD8beta showed that this in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75abee500037edcb4369b0f75b433a5a
https://pubmed.ncbi.nlm.nih.gov/15980863
https://pubmed.ncbi.nlm.nih.gov/15980863
Autor:
Stella Redpath, Shane Marine, Christina M. Lin, PJ Travers, Bee Cheng Sim, Nicholas R. J. Gascoigne, Nathalie Niederberger, Marielena V. McGuire, M. Anna Zal, S. Munir Alam, Pia P. Yachi, Tomasz Zal
Publikováno v:
Immunologic research. 21(2-3)
The kinetics of the interaction between T cell receptor (TCR) and major histocompatibility complex (MHC) has an important role in determining thymocyte-positive and -negative selection in the thymus, as well as in T cell activation. The alpha chain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce75fe4f8ea8b80722475bf51ce851e
https://pubmed.ncbi.nlm.nih.gov/10852121
https://pubmed.ncbi.nlm.nih.gov/10852121
Publikováno v:
The Journal of Immunology. 178:S137-S137
T cells are able to identify minute quantities of antigenic MHC-peptide (MHCp) complexes among a sea of endogenous MHCp presented on an antigen presenting cell. We previously showed that non-stimulatory endogenous peptides can enhance T cell sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f649103b8981649e6f1f164c7475366
https://doi.org/10.4049/jimmunol.178.supp.87.49
https://doi.org/10.4049/jimmunol.178.supp.87.49
Publikováno v:
Immunity. (2):203-211
SummaryHow T cells translate T cell receptor (TCR) recognition of almost identical pMHC ligands into distinct biological responses has remained enigmatic. Although differences in affinity or off rate are important, they offer at best an incomplete ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9eefafaf1ad7692e87a40d17112fe47