Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pia Mach"'
Autor:
Tai L. Ng, Erika J. Olson, Tae Yeon Yoo, H. Sloane Weiss, Yukiye Koide, Peter D. Koch, Nathan J. Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Timothy Z. Chang, Colin Molloy, Jérôme Zürcher, Roger L. Chang, Timothy J. Mitchison, John I. Glass, Debora S. Marks, Jeffrey C. Way, Pamela A. Silver
Publikováno v:
mSystems, Vol 7, Iss 2 (2022)
ABSTRACT Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the abilit
Externí odkaz:
https://doaj.org/article/37ee1fa315624f72abfb551a9d58f267
Publikováno v:
Genes, Vol 8, Iss 1, p 34 (2017)
Site-directed RNA editing is an approach to reprogram genetic information at the RNA level. We recently introduced a novel guideRNA that allows for the recruitment of human ADAR2 to manipulate genetic information. Here, we show that the current guide
Externí odkaz:
https://doaj.org/article/5c2aa00822a646a6ab90aaa98af7d78d
Autor:
Pia Mach, Luca Giorgetti
Publikováno v:
Current Opinion in Genetics & Development. 80:102052
Autor:
Pia Mach, Pavel I. Kos, Yinxiu Zhan, Julie Cramard, Simon Gaudin, Jana Tünnermann, Edoardo Marchi, Jan Eglinger, Jessica Zuin, Mariya Kryzhanovska, Sebastien Smallwood, Laurent Gelman, Gregory Roth, Elphège P. Nora, Guido Tiana, Luca Giorgetti
Publikováno v:
Nat Genet
In mammals, interactions between sequences within topologically associating domains enable control of gene expression across large genomic distances. Yet it is unknown how frequently such contacts occur, how long they last and how they depend on the
Autor:
Pia Mach, Pavel I. Kos, Yinxiu Zhan, Julie Cramard, Simon Gaudin, Jana Tünnermann, Edoardo Marchi, Jan Eglinger, Jessica Zuin, Mariya Kryzhanovska, Sebastien Smallwood, Laurent Gelman, Gregory Roth, Elphège P. Nora, Guido Tiana, Luca Giorgetti
Physical proximity between genomic sequences in mammalian chromosomes controls key biological processes such as transcriptional regulation and DNA repair. Yet it is currently unknown if chromosomal contacts are rare and stable or instead frequent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d796202ca8ad140bfc5e1b5e41ffb2eb
https://doi.org/10.1101/2022.03.03.482826
https://doi.org/10.1101/2022.03.03.482826
Autor:
Jessica Zuin, Gregory Roth, Yinxiu Zhan, Julie Cramard, Josef Redolfi, Ewa Piskadlo, Pia Mach, Mariya Kryzhanovska, Gergely Tihanyi, Hubertus Kohler, Mathias Eder, Christ Leemans, Bas van Steensel, Peter Meister, Sebastien Smallwood, Luca Giorgetti
Publikováno v:
Nature
Zuin, Jessica; Roth, Gregory; Zhan, Yinxiu; Cramard, Julie; Redolfi, Josef; Piskadlo, Ewa; Mach, Pia; Kryzhanovska, Mariya; Tihanyi, Gergely; Kohler, Hubertus; Eder, Mathias; Leemans, Christ; van Steensel, Bas; Meister, Peter; Smallwood, Sebastien; Giorgetti, Luca (2022). Nonlinear control of transcription through enhancer-promoter interactions. Nature, 604(7906), pp. 571-577. Springer Nature 10.1038/s41586-022-04570-y
Zuin, Jessica; Roth, Gregory; Zhan, Yinxiu; Cramard, Julie; Redolfi, Josef; Piskadlo, Ewa; Mach, Pia; Kryzhanovska, Mariya; Tihanyi, Gergely; Kohler, Hubertus; Eder, Mathias; Leemans, Christ; van Steensel, Bas; Meister, Peter; Smallwood, Sebastien; Giorgetti, Luca (2022). Nonlinear control of transcription through enhancer-promoter interactions. Nature, 604(7906), pp. 571-577. Springer Nature 10.1038/s41586-022-04570-y
Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional interactions between enhancers and promoters, notably through CTCF-mediated loops and topologically associating domains (TADs)1–4. However, how chr
Autor:
Tai L. Ng, Erika J. Olson, Tae Yeon Yoo, H. Sloane Weiss, Yukiye Koide, Peter D. Koch, Nathan J. Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Timothy Z. Chang, Colin Molloy, Jérôme Zürcher, Timothy J. Mitchison, John I. Glass, Debora S. Marks, Jeffrey C. Way, Pamela A. Silver
Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the ability to pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f8cae40d6536d81c6190155894f906e
https://doi.org/10.1101/2021.12.14.472572
https://doi.org/10.1101/2021.12.14.472572
Autor:
Jessica, Zuin, Gregory, Roth, Yinxiu, Zhan, Julie, Cramard, Josef, Redolfi, Ewa, Piskadlo, Pia, Mach, Mariya, Kryzhanovska, Gergely, Tihanyi, Hubertus, Kohler, Mathias, Eder, Christ, Leemans, Bas, van Steensel, Peter, Meister, Sebastien, Smallwood, Luca, Giorgetti
Publikováno v:
Nature. 604(7906)
Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional interactions between enhancers and promoters, notably through CTCF-mediated loops and topologically associating domains (TADs)
Autor:
Erika J. Olson, David M. Brown, Timothy Z. Chang, Lin Ding, Tai L. Ng, H. Sloane Weiss, Yukiye Koide, Peter Koch, Nathan Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Joshua Rollins, Yun Zhang, Colin Molloy, Bridget N. Queenan, Timothy Mitchison, Debora Marks, Jeffrey C. Way, John I. Glass, Pamela A. Silver
SummarySuppression of the host intracellular innate immune system is an essential aspect of viral replication. Here, we developed a suite of medium-throughput high-content cell-based assays to reveal the effect of individual coronavirus proteins on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40bfe7bdf6dd437499fec72facddeffd
https://doi.org/10.1101/2021.03.02.433434
https://doi.org/10.1101/2021.03.02.433434
Autor:
Leonie Kurz, Nicolai von Kügelgen, Fabian Barthels, Lena Schmohl, Pia Mach, Jan Bierlmeier, Pascal Reis, Christian Freund, Mike Schutkowski, Dirk Schwarzer
Publikováno v:
Bioorganicmedicinal chemistry. 25(18)
Sortases catalyze the attachment of surface proteins to the peptidoglycan layer of gram-positive bacteria and further represent powerful tools of protein chemistry. During catalysis sortases cleave a donor substrate containing the LPxTG (x=any amino