Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Pia Lautala"'
Autor:
Pia Lautala, Mohamed Ouzzine, Katia Monastyrskaia, Brian Burchell, Jyrki Taskinen, Kenneth Lundstrom, Ismo Ulmanen, Tarja Forsman
Publikováno v:
Life Sciences. 67:2473-2484
Human UDP-glucuronosyltransferases (UGTs) 1A6 and 1A9 were expressed using Semliki Forest virus (SFV) vectors. Infection of chinese hamster lung fibroblast V79 cells with recombinant SFV-UGT viruses resulted in efficient protein expression as detecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31d63c4c9c6d775662c326d86b6adc1
https://doi.org/10.1016/s0024-3205(00)00831-6
https://doi.org/10.1016/s0024-3205(00)00831-6
Publikováno v:
Pharmacology & Toxicology. 80:152-158
Rats were treated with acetone, pyrazole, phenobarbital, 4,4'-methylenebis-(2-chloroaniline) (MOCA), 3-methylcholanthrene, creosote oil, or a mixture of polychlorinated biphenyls (Aroclor 1254) to study the inducibility and enzyme kinetics of UDP-glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a7c450d4d1a4abda62407025bbf9c8
https://doi.org/10.1111/j.1600-0773.1997.tb00389.x
https://doi.org/10.1111/j.1600-0773.1997.tb00389.x
Publikováno v:
Pharmaceutical Research. 14:1444-1448
Purpose. Nitrocatechol COMT inhibitors are a new class of bioactive compounds, for which glucuronidation is the most important metabolic pathway. The objective was to characterize the enzyme kinetics of nitrocatechol glucuronidation to improve the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9deec257591e18d214e06f3b48b02272
https://doi.org/10.1023/a:1012133008134
https://doi.org/10.1023/a:1012133008134
Publikováno v:
Molecular pharmacology. 59(2)
Molecular mechanisms determining the turn-over rate and specificity of catechol O-methylation were studied by combining enzyme kinetic measurements, computational modeling of substrate properties and fitting ligands in a 3D model of the active site o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225c8ab1d51a5c41fdd01fabd04606cb
https://pubmed.ncbi.nlm.nih.gov/11160877
https://pubmed.ncbi.nlm.nih.gov/11160877
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 736(1-2)
A new chromatographic catechol O-methyltransferase (COMT) assay based on S-adenosyl-L-[methyl-14C]methionine and on-line radioactivity detection was developed. With minor modifications in the mobile phase composition the methylation velocities for 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc622c59046a5a78ee11fe813bac7e6
https://pubmed.ncbi.nlm.nih.gov/10676994
https://pubmed.ncbi.nlm.nih.gov/10676994